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Select item 119146151.

Decoding host-microbe interactions with engineered human organoids

Lucas A Meirelles, Alexandre Persat

EMBO J. 2025 Mar; 44(6): 1569–1573. Published online 2025 Feb 21. doi: 10.1038/s44318-025-00387-3

PMCID:: PMC11914615

Article PDF–490K

Select item 119146062.

Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritance

Ziming Wang, Tirawit Meerod, Nuria Cortes-Silva, Ason C-Y Chiang, Ziyan Nie, Ying Di, Peiqiang Mu, Ankit Verma, Adam James Reid, Hansong Ma

EMBO J. 2025 Mar; 44(6): 1724–1748. Published online 2025 Feb 11. doi: 10.1038/s44318-025-00378-4

PMCID:: PMC11914606

Article PDF–14M

Select item 119145673.

Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function

Ceren Incedal Nilsson, Özge Dumral, Gonzalo Sanchez, Beichen Xie, Andreas Müller, Michele Solimena, Huixia Ren, Olof Idevall-Hagren

EMBO J. 2025 Mar; 44(6): 1663–1691. Published online 2025 Feb 12. doi: 10.1038/s44318-025-00383-7

PMCID:: PMC11914567

Article PDF–6.3M

Select item 119144294.

Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs

Niklas Peters, Sibylle Kanngießer, Oliver Pajonk, Rafael Salazar Claros, Petra Hubbe, Axel Mogk, Sebastian Schuck

EMBO J. 2025 Mar; 44(6): 1774–1803. Published online 2025 Feb 7. doi: 10.1038/s44318-025-00375-7

PMCID:: PMC11914429

Article PDF–4.6M

Select item 119142665.

Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover

Asieh Etemad, Yosuke Tanaka, Shuo Wang, Mordechai Slae, Mutaz Sultan, Orly Elpeleg, Nobutaka Hirokawa

EMBO J. 2025 Mar; 44(6): 1608–1640. Published online 2025 Feb 7. doi: 10.1038/s44318-025-00366-8

PMCID:: PMC11914266

Article PDF–31M

Select item 119141106.

SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation

Wei Li, Jing Han, Bin Huang, Tengteng Xu, Yihong Wan, Dan Luo, Weiyao Kong, Ying Yu, Lei Zhang, Yong Nian, Bo Chu, Chengqian Yin

EMBO J. 2025 Mar; 44(6): 1641–1662. Published online 2025 Jan 29. doi: 10.1038/s44318-025-00369-5

PMCID:: PMC11914110

Article PDF–8.1M

Select item 119141057.

Modulation of tumor inflammatory signaling and drug sensitivity by CMTM4

Yitian Xu, Kyeongah Kang, Brian A Coakley, Samuel Eisenstein, Arshiya Parveen, Sunny Mai, Yuan Shuo Wang, Junjun Zheng, Debasish Boral, Junhua Mai, William Pan, Licheng Zhang, Stuart A Aaronson, Bingliang Fang, Celia Divino, Bin Zhang, Won-Min Song, Mien-Chie Hung, Ping-Ying Pan, Shu-Hsia Chen

EMBO J. 2025 Mar; 44(6): 1866–1883. Published online 2025 Feb 13. doi: 10.1038/s44318-024-00330-y

PMCID:: PMC11914105

Article PDF–3.2M

Select item 118764488.

Arginine: at the crossroads of nitrogen metabolism

Tak Shun Fung, Keun Woo Ryu, Craig B Thompson

EMBO J. 2025 Mar; 44(5): 1275–1293. Published online 2025 Feb 7. doi: 10.1038/s44318-025-00379-3

PMCID:: PMC11876448

Article PDF–1.7M

Select item 118763009.

Author Correction: An extrinsic motor directs chromatin loop formation by cohesin

Thomas M Guérin, Christopher Barrington, Georgii Pobegalov, Maxim I Molodtsov, Frank Uhlmann

EMBO J. 2025 Mar; 44(5): 1563–1568. Published online 2025 Jan 31. doi: 10.1038/s44318-024-00341-9

Corrects:: EMBO J. 2024 Oct; 43(19): 4173–4196.

PMCID:: PMC11876300

Correction PDF–5.2M

Select item 1187664110.

Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer

Shuang Li, Meng Sun, Yun Cui, Dongyang Guo, Feng Yang, Qiang Sun, Yinuo Ding, Mengjie Li, Yiman Liu, Guangshuo Ou, Wei Zhuo, Tianhua Zhou

EMBO J. 2025 Mar; 44(5): 1464–1487. Published online 2025 Jan 21. doi: 10.1038/s44318-025-00363-x

PMCID:: PMC11876641

Article PDF–12M

Select item 1187632511.

The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination

Adeola A Fagunloye, Alessio De Magis, Jordan H Little, Isabela Contreras, Tanis J Dorwart, Braulio Bonilla, Kushol Gupta, Nathan Clark, Theresa Zacheja, Katrin Paeschke, Kara A Bernstein

EMBO J. 2025 Mar; 44(5): 1512–1539. Published online 2025 Jan 21. doi: 10.1038/s44318-025-00365-9

PMCID:: PMC11876325

Article PDF–3.2M

Select item 1187634712.

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis

Li Shi, Hao Chen, Yuxin Zhang, Donghao An, Mengyao Qin, Wanting Yu, Bin Wen, Dandan He, Haiping Hao, Jing Xiong

EMBO J. 2025 Mar; 44(5): 1442–1463. Published online 2025 Jan 17. doi: 10.1038/s44318-025-00362-y

PMCID:: PMC11876347

Article PDF–14M

Select item 1187631313.

The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice

Kazumi Shimaoka, Kei Hori, Satoshi Miyashita, Yukiko U Inoue, Nao K N Tabe, Asami Sakamoto, Ikuko Hasegawa, Kayo Nishitani, Kunihiko Yamashiro, Saki F Egusa, Shoji Tatsumoto, Yasuhiro Go, Manabu Abe, Kenji Sakimura, Takayoshi Inoue, Takuya Imamura, Mikio Hoshino

EMBO J. 2025 Mar; 44(5): 1354–1378. Published online 2025 Jan 15. doi: 10.1038/s44318-024-00343-7

PMCID:: PMC11876313

Article PDF–6.0M

Select item 1179096714.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

Kyungtae Lim, Eimear N Rutherford, Livia Delpiano, Peng He, Weimin Lin, Dawei Sun, Dick J H Van den Boomen, James R Edgar, Jae Hak Bang, Alexander Predeus, Sarah A Teichmann, John C Marioni, Lydia E Matesic, Joo-Hyeon Lee, Paul J Lehner, Stefan J Marciniak, Emma L Rawlins, Jennifer A Dickens

EMBO J. 2025 Feb; 44(3): 639–664. Published online 2025 Jan 15. doi: 10.1038/s44318-024-00328-6

PMCID:: PMC11790967

Article PDF–10M

Select item 1187643415.

Glycogen synthase GYS1 overactivation contributes to glycogen insolubility and malto-oligoglucan-associated neurodegenerative disease

Silvia Nitschke, Alina P Montalbano, Megan E Whiting, Brandon H Smith, Neije Mukherjee-Roy, Charlotte R Marchioni, Mitchell A Sullivan, Xiaochu Zhao, Peixiang Wang, Howard Mount, Mayank Verma, Berge A Minassian, Felix Nitschke

EMBO J. 2025 Mar; 44(5): 1379–1413. Published online 2025 Jan 13. doi: 10.1038/s44318-024-00339-3