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Select item 119077921.

Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditis

Xiuyun Duan, Li Zhang, Keyu Liu, Kaiyin Guo, Yingnan You, Hailin Jia, Shan Zhou, Bo Han

Biol Direct. 2025; 20: 30. Published online 2025 Mar 14. doi: 10.1186/s13062-025-00621-2

PMCID:: PMC11907792

Article PDF–4.8M

Select item 118952722.

Differential growth and flowering capacity of tulip bulbs and the potential involvement of PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINS (PEBPs)

Francesca Bellinazzo, Irene Manders, Bas Heidemann, Manuel Aguirre Bolanos, Evelien Stouten, Jacqueline Busscher, Dolores Abarca, Froukje van der Wal, Marcelo Carnier Dornelas, Gerco C. Angenent, Marcel Proveniers, Harm Nijveen, Richard G. H. Immink

Biol Direct. 2025; 20: 29. Published online 2025 Mar 10. doi: 10.1186/s13062-025-00625-y

PMCID:: PMC11895272

Article PDF–2.0M

Select item 118951753.

The role of estrogen in the sex difference for the risk factors of heart failure with preserved ejection fraction

Jun Du, Jiaqi Liu, Xiaoya Wang, Xiaowu Wang, Yu Ma, Sipan Zhang, Zilin Li, Jipeng Ma, Jincheng Liu

Biol Direct. 2025; 20: 28. Published online 2025 Mar 10. doi: 10.1186/s13062-025-00618-x

PMCID:: PMC11895175

Article PDF–1.4M

Select item 118840154.

HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification

Enshuang Guo, Lei Li, Jiankun Yang, Yongjian Zhou, Lu Bai, Weiwei Zhu, Qiuyue Hu, Huifen Wang, Hongqiang Liu

Biol Direct. 2025; 20: 26. Published online 2025 Mar 5. doi: 10.1186/s13062-025-00620-3

PMCID:: PMC11884015

Article PDF–14M

Select item 118839205.

E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma

Xu Zhang, Fayu Liu, Qigen Fang, Changfu Sun, Jie Fan

Biol Direct. 2025; 20: 27. Published online 2025 Mar 5. doi: 10.1186/s13062-025-00622-1

PMCID:: PMC11883920

Article PDF–11M

Select item 118634936.

Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function: Nucleolin promotes Ang II-mediated VSMC phenotypic switching

Li Fang, Zhijie Shen, Yinzhuang Zhang, Zhuoni Mao, Dan Huang, Chenyu Lou

Biol Direct. 2025; 20: 24. Published online 2025 Feb 26. doi: 10.1186/s13062-025-00615-0

PMCID:: PMC11863493

Article PDF–9.4M

Select item 118293697.

Functional improvement of natural Saccharomyces cerevisiae yeast strains by cell surface molecular engineering

Sara Granuzzo, Monica Rossetto, Lucio Zennaro, Francesca Righetto, Paolo Antoniali, Raffaele Lopreiato

Biol Direct. 2025; 20: 22. Published online 2025 Feb 14. doi: 10.1186/s13062-025-00614-1

PMCID:: PMC11829369

Article PDF–4.1M

Select item 118067778.

cGAS-STING targeting offers therapy choice in lung diseases

Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

Biol Direct. 2025; 20: 20. Published online 2025 Feb 7. doi: 10.1186/s13062-025-00611-4

PMCID:: PMC11806777

Article PDF–4.2M

Select item 117961389.

Ultrastructural studies distinguish skin diversities among Galápagos iguanas

Manuel Scimeca, Rita Bonfiglio, Giuliano Colosimo, Eleonora Candi, Glenn P. Gerber, Gregory A. Lewbart, Alessandro Mauriello, Gerry Melino, Christian Sevilla, Yufang Shi, Ying Wang, Gabriele Gentile

Biol Direct. 2025; 20: 16. Published online 2025 Feb 4. doi: 10.1186/s13062-025-00602-5

PMCID:: PMC11796138

Article PDF–5.1M

Select item 1178079210.

Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning

Yiqin Yang, Mei Dong

Biol Direct. 2025; 20: 15. Published online 2025 Jan 29. doi: 10.1186/s13062-025-00600-7

PMCID:: PMC11780792

Article PDF–5.9M

Select item 1175874111.

BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway

Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

Biol Direct. 2025; 20: 13. Published online 2025 Jan 24. doi: 10.1186/s13062-025-00606-1

PMCID:: PMC11758741

Article PDF–2.9M

Select item 1175590112.

Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts

Yi Wang, Guihua Chen, Deng Li

Biol Direct. 2025; 20: 12. Published online 2025 Jan 23. doi: 10.1186/s13062-025-00607-0

Corrects:: Biol Direct. 2024; 19: 136.

PMCID:: PMC11755901

Correction PDF–571K

Select item 1175316913.

Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples

Xinlei Chen, Youbing Guo, Xiaorong Gu, Danyi Wen

Biol Direct. 2025; 20: 11. Published online 2025 Jan 21. doi: 10.1186/s13062-025-00598-y

PMCID:: PMC11753169

Article PDF–3.4M

Select item 1174486714.

Methyltransferase-like 7B participates in bladder cancer via ACSL3 m⁶A modification in a ferroptosis manner

Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

Biol Direct. 2025; 20: 9. Published online 2025 Jan 20. doi: 10.1186/s13062-025-00597-z

PMCID:: PMC11744867

Article PDF–5.7M

Select item 1173722915.

Matrix Metalloproteinase-9 is associated with tumor microenvironment remodeling of bladder cancer

Fang Fang, Tiange Wu, Mengxue Wang, Wenchao Li, Zonghao You, Ming Chen, Han Guan

Biol Direct. 2025; 20: 8. Published online 2025 Jan 16. doi: 10.1186/s13062-025-00599-x

PMCID:: PMC11737229

Article PDF–5.2M

Select item 1173457216.

Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma

Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

Biol Direct. 2025; 20: 7. Published online 2025 Jan 15. doi: 10.1186/s13062-025-00594-2

PMCID:: PMC11734572

Article PDF–14M

Select item 1173117417.

Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9

Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu, Xuqi Li

Biol Direct. 2025; 20: 6. Published online 2025 Jan 14. doi: 10.1186/s13062-025-00595-1