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Hyperemesis gravidarum, susceptibility to(HG)

MedGen UID:
1857498
•Concept ID:
C5889860
•
Finding
Synonym: HG
 
Gene (location): GDF15 (19p13.11)
 
Monarch Initiative: MONDO:0958238
OMIM®: 620730

Definition

Hyperemesis gravidarum (HG) is characterized by severe nausea and vomiting in pregnancy. It occurs in up to 2% of pregnancies and results in significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity (Fejzo et al., 2019). [from OMIM]

Recent clinical studies

Etiology

Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.
Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S
Nature 2024 Jan;625(7996):760-767. Epub 2023 Dec 13 doi: 10.1038/s41586-023-06921-9. PMID: 38092039Free PMC Article
Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2).
Fejzo MS, Myhre R, Colodro-Conde L, MacGibbon KW, Sinsheimer JS, Reddy MVPL, Pajukanta P, Nyholt DR, Wright MJ, Martin NG, Engel SM, Medland SE, Magnus P, Mullin PM
Mol Cell Endocrinol 2017 Jan 5;439:308-316. Epub 2016 Sep 20 doi: 10.1016/j.mce.2016.09.017. PMID: 27663074Free PMC Article
Hyperemesis gravidarum and long-term health of the offspring.
Ayyavoo A, Derraik JG, Hofman PL, Cutfield WS
Am J Obstet Gynecol 2014 Jun;210(6):521-5. Epub 2013 Nov 23 doi: 10.1016/j.ajog.2013.11.035. PMID: 24280249
Familial aggregation of hyperemesis gravidarum.
Zhang Y, Cantor RM, MacGibbon K, Romero R, Goodwin TM, Mullin PM, Fejzo MS
Am J Obstet Gynecol 2011 Mar;204(3):230.e1-7. Epub 2010 Oct 25 doi: 10.1016/j.ajog.2010.09.018. PMID: 20974461Free PMC Article

Diagnosis

Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.
Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S
Nature 2024 Jan;625(7996):760-767. Epub 2023 Dec 13 doi: 10.1038/s41586-023-06921-9. PMID: 38092039Free PMC Article
Hyperemesis gravidarum and long-term health of the offspring.
Ayyavoo A, Derraik JG, Hofman PL, Cutfield WS
Am J Obstet Gynecol 2014 Jun;210(6):521-5. Epub 2013 Nov 23 doi: 10.1016/j.ajog.2013.11.035. PMID: 24280249
Pregnancy outcome in hyperemesis gravidarum--the role of fetal gender.
Peled Y, Melamed N, Hiersch L, Hadar E, Wiznitzer A, Yogev Y
J Matern Fetal Neonatal Med 2013 Nov;26(17):1753-7. Epub 2013 May 24 doi: 10.3109/14767058.2013.798293. PMID: 23611752

Therapy

Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.
Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series.
Fejzo MS, Romero R, Goodwin TM
Fertil Steril 2010 Jan;93(1):267.e9-11. Epub 2009 Oct 29 doi: 10.1016/j.fertnstert.2009.09.022. PMID: 19878938Free PMC Article

Prognosis

Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.
Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article

Clinical prediction guides

Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.
Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article
Maternal susceptibility to nausea and vomiting of pregnancy: is the vestibular system involved?
Black FO
Am J Obstet Gynecol 2002 May;186(5 Suppl Understanding):S204-9. doi: 10.1067/mob.2002.122602. PMID: 12011887

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