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Diffuse hemispheric glioma, H3 G34-mutant

MedGen UID:
1802464
•Concept ID:
C5669880
•
Neoplastic Process
Synonym: Diffuse Hemispheric Glioma, H3 G34-Mutant

Definition

A WHO grade 4 diffuse glioma arising in the cerebral hemispheres. It is characterized by the presence of missense mutation of the H3-3A gene. The prognosis is poor. [from NCI]

Recent clinical studies

Etiology

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant.
Kibe Y, Chalise L, Ohka F, Motomura K, Nakahara N, Aoki K, Deguchi S, Shiba Y, Takeuchi K, Iwami K, Yamaguchi J, Shimizu H, Maeda S, Takido Y, Yamamoto R, Okuno Y, Sakai A, Karube K, Saito R
Acta Neuropathol Commun 2025 Feb 27;13(1):43. doi: 10.1186/s40478-025-01945-w. PMID: 40016857Free PMC Article
Long-term survival after local immunotherapy for malignant gliomas: a retrospective study with 20 years follow-up.
Duan H, He Z, Chen Z, Chen Y, Hu W, Sai K, Zhang X, Xia J, Li Y, Liu R, Zou C, Chen Z, Mou Y
BMC Immunol 2024 Dec 20;25(1):83. doi: 10.1186/s12865-024-00676-2. PMID: 39707189Free PMC Article
Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review.
Kegoya Y, Otani Y, Inoue Y, Mizuta R, Higaki F, Washio K, Koizumi S, Kurozumi K, Ishida J, Fujii K, Yamamoto N, Tanaka Y, Date I
J Neurooncol 2024 Mar;167(1):201-210. Epub 2024 Mar 1 doi: 10.1007/s11060-024-04587-5. PMID: 38427132Free PMC Article
H3 G34-mutant high-grade gliomas: integrated clinical, imaging and pathological characterisation of a single-centre case series.
Lavrador JP, Reisz Z, Sibtain N, Rajwani K, Baig Mirza A, Vergani F, Gullan R, Bhangoo R, Ashkan K, Bleil C, Zebian B, Clark B, Laxton R, King A, Bodi I, Al-Saraj S
Acta Neurochir (Wien) 2023 Jun;165(6):1615-1633. Epub 2023 Mar 16 doi: 10.1007/s00701-023-05545-2. PMID: 36929449

Diagnosis

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant.
Kibe Y, Chalise L, Ohka F, Motomura K, Nakahara N, Aoki K, Deguchi S, Shiba Y, Takeuchi K, Iwami K, Yamaguchi J, Shimizu H, Maeda S, Takido Y, Yamamoto R, Okuno Y, Sakai A, Karube K, Saito R
Acta Neuropathol Commun 2025 Feb 27;13(1):43. doi: 10.1186/s40478-025-01945-w. PMID: 40016857Free PMC Article
H3 G34-mutant high-grade gliomas: integrated clinical, imaging and pathological characterisation of a single-centre case series.
Lavrador JP, Reisz Z, Sibtain N, Rajwani K, Baig Mirza A, Vergani F, Gullan R, Bhangoo R, Ashkan K, Bleil C, Zebian B, Clark B, Laxton R, King A, Bodi I, Al-Saraj S
Acta Neurochir (Wien) 2023 Jun;165(6):1615-1633. Epub 2023 Mar 16 doi: 10.1007/s00701-023-05545-2. PMID: 36929449
Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S
Pathologica 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. PMID: 36534421Free PMC Article
Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review.
Lasocki A, Abdalla G, Chow G, Thust SC
Cancer Imaging 2022 Nov 17;22(1):63. doi: 10.1186/s40644-022-00500-3. PMID: 36397143Free PMC Article
Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Pinarbasi ES, Makise N, Ota Y, Kim J, Srinivasan A, Moritani T
J Neuroimaging 2022 Jan;32(1):17-27. Epub 2021 Oct 11 doi: 10.1111/jon.12939. PMID: 34632671

Prognosis

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant.
Kibe Y, Chalise L, Ohka F, Motomura K, Nakahara N, Aoki K, Deguchi S, Shiba Y, Takeuchi K, Iwami K, Yamaguchi J, Shimizu H, Maeda S, Takido Y, Yamamoto R, Okuno Y, Sakai A, Karube K, Saito R
Acta Neuropathol Commun 2025 Feb 27;13(1):43. doi: 10.1186/s40478-025-01945-w. PMID: 40016857Free PMC Article
Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review.
Kegoya Y, Otani Y, Inoue Y, Mizuta R, Higaki F, Washio K, Koizumi S, Kurozumi K, Ishida J, Fujii K, Yamamoto N, Tanaka Y, Date I
J Neurooncol 2024 Mar;167(1):201-210. Epub 2024 Mar 1 doi: 10.1007/s11060-024-04587-5. PMID: 38427132Free PMC Article
Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review.
Lasocki A, Abdalla G, Chow G, Thust SC
Cancer Imaging 2022 Nov 17;22(1):63. doi: 10.1186/s40644-022-00500-3. PMID: 36397143Free PMC Article
High frequency of PDGFRA and MUC family gene mutations in diffuse hemispheric glioma, H3 G34-mutant: a glimmer of hope?
Hu W, Duan H, Zhong S, Zeng J, Mou Y
J Transl Med 2022 Feb 2;20(1):64. doi: 10.1186/s12967-022-03258-1. PMID: 35109850Free PMC Article
Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Pinarbasi ES, Makise N, Ota Y, Kim J, Srinivasan A, Moritani T
J Neuroimaging 2022 Jan;32(1):17-27. Epub 2021 Oct 11 doi: 10.1111/jon.12939. PMID: 34632671

Clinical prediction guides

Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review.
Kegoya Y, Otani Y, Inoue Y, Mizuta R, Higaki F, Washio K, Koizumi S, Kurozumi K, Ishida J, Fujii K, Yamamoto N, Tanaka Y, Date I
J Neurooncol 2024 Mar;167(1):201-210. Epub 2024 Mar 1 doi: 10.1007/s11060-024-04587-5. PMID: 38427132Free PMC Article
Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review.
Lasocki A, Abdalla G, Chow G, Thust SC
Cancer Imaging 2022 Nov 17;22(1):63. doi: 10.1186/s40644-022-00500-3. PMID: 36397143Free PMC Article
Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Pinarbasi ES, Makise N, Ota Y, Kim J, Srinivasan A, Moritani T
J Neuroimaging 2022 Jan;32(1):17-27. Epub 2021 Oct 11 doi: 10.1111/jon.12939. PMID: 34632671

Recent systematic reviews

Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review.
Lasocki A, Abdalla G, Chow G, Thust SC
Cancer Imaging 2022 Nov 17;22(1):63. doi: 10.1186/s40644-022-00500-3. PMID: 36397143Free PMC Article
Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Pinarbasi ES, Makise N, Ota Y, Kim J, Srinivasan A, Moritani T
J Neuroimaging 2022 Jan;32(1):17-27. Epub 2021 Oct 11 doi: 10.1111/jon.12939. PMID: 34632671

Supplemental Content

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

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