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Homocysteine level elevated

MedGen UID:
1618143
•Concept ID:
C4551332
•
Finding
Synonym: Homocysteine, total plasma, elevated
SNOMED CT: Homocysteine level elevated (456231000124106); Homocysteine level above reference range (456231000124106)

Professional guidelines

PubMed

Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects.
Wenstrom KD, Johanning GL, Owen J, Johnston KE, Acton S, Tamura T
Am J Med Genet 2000 Jan 3;90(1):12-6. doi: 10.1002/(sici)1096-8628(20000103)90:1<12::aid-ajmg3>3.0.co;2-h. PMID: 10602111

Recent clinical studies

Etiology

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
Williamson JM, Arthurs AL, Smith MD, Roberts CT, Jankovic-Karasoulos T
Nutrients 2022 Sep 22;14(19) doi: 10.3390/nu14193930. PMID: 36235580Free PMC Article
Homocysteine and Hyperhomocysteinaemia.
Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER
Curr Med Chem 2019;26(16):2948-2961. doi: 10.2174/0929867325666180313105949. PMID: 29532755
Inherited Thrombophilia.
Phillippe HM, Hornsby LB, Treadway S, Armstrong EM, Bellone JM
J Pharm Pract 2014 Jun;27(3):227-33. Epub 2014 Apr 16 doi: 10.1177/0897190014530390. PMID: 24739277
Homocysteine.
Maron BA, Loscalzo J
Clin Lab Med 2006 Sep;26(3):591-609, vi. doi: 10.1016/j.cll.2006.06.008. PMID: 16938586
Homocysteine metabolism.
Selhub J
Annu Rev Nutr 1999;19:217-46. doi: 10.1146/annurev.nutr.19.1.217. PMID: 10448523

Diagnosis

Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review.
Tøndel BG, Morelli VM, Hansen JB, Braekkan SK
J Thromb Haemost 2022 Oct;20(10):2173-2186. Epub 2022 Jul 28 doi: 10.1111/jth.15813. PMID: 35815351Free PMC Article
Hyperhomocysteinemia and cardiovascular diseases.
Guieu R, Ruf J, Mottola G
Ann Biol Clin (Paris) 2022 Feb 1;80(1):7-14. doi: 10.1684/abc.2021.1694. PMID: 35129442
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Hyperhomocysteinemia--case report.
Fonseca N, Vidal N, Santos J, Brito AP, Bernardino L, Silvestre I, Inês L
Rev Port Cardiol 2003 Feb;22(2):223-30. PMID: 12769002
Inherited hypercoagulable states.
Rao AK, Sheth S, Kaplan R
Vasc Med 1997 Nov;2(4):313-20. doi: 10.1177/1358863X9700200407. PMID: 9575605

Therapy

Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review.
Tøndel BG, Morelli VM, Hansen JB, Braekkan SK
J Thromb Haemost 2022 Oct;20(10):2173-2186. Epub 2022 Jul 28 doi: 10.1111/jth.15813. PMID: 35815351Free PMC Article
Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Association between neuropathy and B-vitamins: A systematic review and meta-analysis.
Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867
Homocysteine and Hyperhomocysteinaemia.
Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER
Curr Med Chem 2019;26(16):2948-2961. doi: 10.2174/0929867325666180313105949. PMID: 29532755
Inherited Thrombophilia.
Phillippe HM, Hornsby LB, Treadway S, Armstrong EM, Bellone JM
J Pharm Pract 2014 Jun;27(3):227-33. Epub 2014 Apr 16 doi: 10.1177/0897190014530390. PMID: 24739277

Prognosis

Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review.
Tøndel BG, Morelli VM, Hansen JB, Braekkan SK
J Thromb Haemost 2022 Oct;20(10):2173-2186. Epub 2022 Jul 28 doi: 10.1111/jth.15813. PMID: 35815351Free PMC Article
Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Raghubeer S, Matsha TE
Nutrients 2021 Dec 20;13(12) doi: 10.3390/nu13124562. PMID: 34960114Free PMC Article
Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Homocysteine.
Maron BA, Loscalzo J
Clin Lab Med 2006 Sep;26(3):591-609, vi. doi: 10.1016/j.cll.2006.06.008. PMID: 16938586

Clinical prediction guides

Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Association between neuropathy and B-vitamins: A systematic review and meta-analysis.
Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867
Homocysteine and age-associated disorders.
Ostrakhovitch EA, Tabibzadeh S
Ageing Res Rev 2019 Jan;49:144-164. Epub 2018 Nov 2 doi: 10.1016/j.arr.2018.10.010. PMID: 30391754
Homocysteine level and risk of fracture: A meta-analysis and systematic review.
Yang J, Hu X, Zhang Q, Cao H, Wang J, Liu B
Bone 2012 Sep;51(3):376-82. Epub 2012 Jun 26 doi: 10.1016/j.bone.2012.05.024. PMID: 22749888
Homocysteine.
Maron BA, Loscalzo J
Clin Lab Med 2006 Sep;26(3):591-609, vi. doi: 10.1016/j.cll.2006.06.008. PMID: 16938586

Recent systematic reviews

Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review.
Tøndel BG, Morelli VM, Hansen JB, Braekkan SK
J Thromb Haemost 2022 Oct;20(10):2173-2186. Epub 2022 Jul 28 doi: 10.1111/jth.15813. PMID: 35815351Free PMC Article
Thromboembolic complications of recreational nitrous oxide (ab)use: a systematic review.
Oulkadi S, Peters B, Vliegen AS
J Thromb Thrombolysis 2022 Nov;54(4):686-695. Epub 2022 Jun 27 doi: 10.1007/s11239-022-02673-x. PMID: 35759070
B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
Wang Z, Zhu W, Xing Y, Jia J, Tang Y
Nutr Rev 2022 Mar 10;80(4):931-949. doi: 10.1093/nutrit/nuab057. PMID: 34432056
Association between neuropathy and B-vitamins: A systematic review and meta-analysis.
Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867
Inflammation and cerebral small vessel disease: A systematic review.
Low A, Mak E, Rowe JB, Markus HS, O'Brien JT
Ageing Res Rev 2019 Aug;53:100916. Epub 2019 Jun 10 doi: 10.1016/j.arr.2019.100916. PMID: 31181331

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