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Abnormal optic chiasm morphology

MedGen UID:
1368546
•Concept ID:
C4476628
•
Anatomical Abnormality
Synonym: Abnormality of optic chiasm morphology
 
HPO: HP:0025163

Definition

A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal optic chiasm morphology

Professional guidelines

PubMed

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
Rathke cleft cyst. MRI criteria for presumptive diagnosis.
Gaddikeri S, Vattoth S, Riley KO, DeHoff GW, Smith CB, Combs JT, Roberson GH
Neurosciences (Riyadh) 2013 Jul;18(3):258-63. PMID: 23887217

Recent clinical studies

Etiology

Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
Mechanisms for lesion localization in neuromyelitis optica spectrum disorders.
Bradl M, Reindl M, Lassmann H
Curr Opin Neurol 2018 Jun;31(3):325-333. doi: 10.1097/WCO.0000000000000551. PMID: 29465432Free PMC Article
Uncrossed Asymmetry in Pattern Visual Evoked Potentials: A Reappraisal.
Ericson EJ, Lubin J, Minieka MM, Nishida T
J Clin Neurophysiol 2016 Oct;33(5):450-453. doi: 10.1097/WNP.0000000000000263. PMID: 26886102
Abnormal lateral geniculate nucleus and optic chiasm in human albinism.
Mcketton L, Kelly KR, Schneider KA
J Comp Neurol 2014 Aug 1;522(11):2680-7. Epub 2014 Apr 12 doi: 10.1002/cne.23565. PMID: 24639208
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989

Diagnosis

Fetal-onset Alexander disease with radiological-neuropathological correlation.
Devos J, Devriendt K, Richter J, Jansen K, Baldewijns M, Thal DR, Aertsen M
Pediatr Radiol 2023 Sep;53(10):2149-2153. Epub 2023 Jul 17 doi: 10.1007/s00247-023-05710-w. PMID: 37455276
Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
Non-compressive disorders of the chiasm.
Purvin VA, Kawasaki A
Curr Neurol Neurosci Rep 2014 Jul;14(7):455. doi: 10.1007/s11910-014-0455-7. PMID: 24788948
Pituitary incidentalomas.
Molitch ME
Endocrinol Metab Clin North Am 1997 Dec;26(4):725-40. doi: 10.1016/s0889-8529(05)70279-6. PMID: 9429857
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Therapy

Central Retinal Vein Occlusion Secondary to Bonnet-Dechaume-Blanc Syndrome.
Hsu SL, Wang TJ
Ophthalmology 2022 Jan;129(1):34. doi: 10.1016/j.ophtha.2021.04.033. PMID: 34930549
Optic chiasm involvement on MRI with ethambutol-induced bitemporal hemianopia.
Osaguona VB, Sharpe JA, Awaji SA, Farb RI, Sundaram AN
J Neuroophthalmol 2014 Jun;34(2):155-8. doi: 10.1097/WNO.0000000000000095. PMID: 24647140
Pituitary incidentaloma.
Orija IB, Weil RJ, Hamrahian AH
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):47-68. doi: 10.1016/j.beem.2011.07.003. PMID: 22305452
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Prognosis

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
A case of idiopathic granulomatous hypophysitis.
Chung CH, Song MS, Cho HD, Jeong du S, Kim YJ, Bae HG, Kim SJ
Korean J Intern Med 2012 Sep;27(3):346-9. Epub 2012 Sep 1 doi: 10.3904/kjim.2012.27.3.346. PMID: 23019401Free PMC Article
Ciliated craniopharyngioma--case report and pathological study.
Okada T, Fujitsu K, Miyahara K, Ichikawa T, Takemoto Y, Niino H, Yagishita S, Shiina T
Acta Neurochir (Wien) 2010 Feb;152(2):303-6; discussion 307. Epub 2009 Jul 21 doi: 10.1007/s00701-009-0448-5. PMID: 19626269
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989

Clinical prediction guides

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
Mechanisms for lesion localization in neuromyelitis optica spectrum disorders.
Bradl M, Reindl M, Lassmann H
Curr Opin Neurol 2018 Jun;31(3):325-333. doi: 10.1097/WCO.0000000000000551. PMID: 29465432Free PMC Article
A case of idiopathic granulomatous hypophysitis.
Chung CH, Song MS, Cho HD, Jeong du S, Kim YJ, Bae HG, Kim SJ
Korean J Intern Med 2012 Sep;27(3):346-9. Epub 2012 Sep 1 doi: 10.3904/kjim.2012.27.3.346. PMID: 23019401Free PMC Article
Pituitary incidentalomas.
Molitch ME
Endocrinol Metab Clin North Am 1997 Dec;26(4):725-40. doi: 10.1016/s0889-8529(05)70279-6. PMID: 9429857
X-linked hydrocephalus. Further observations.
Viseskul C, Gilbert EF, Opitz JM
Z Kinderheilkd 1975;119(2):111-21. doi: 10.1007/BF00443565. PMID: 1094758

Recent systematic reviews

Anterior visual pathway cavernous malformations.
Tan T, Tee JW, Trost N, McKelvie P, Wang YY
J Clin Neurosci 2015 Feb;22(2):258-67. Epub 2014 Nov 11 doi: 10.1016/j.jocn.2014.07.027. PMID: 25439746

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