U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of pain sensation

MedGen UID:
869265
Concept ID:
C4023691
Anatomical Abnormality
HPO: HP:0010832

Definition

Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain. [from HPO]

Professional guidelines

PubMed

Lacy BE, Cangemi D, Vazquez-Roque M
Clin Gastroenterol Hepatol 2021 Feb;19(2):219-231.e1. Epub 2020 Apr 1 doi: 10.1016/j.cgh.2020.03.056. PMID: 32246999
Gilmour GS, Nielsen G, Teodoro T, Yogarajah M, Coebergh JA, Dilley MD, Martino D, Edwards MJ
J Neurol 2020 Jul;267(7):2164-2172. Epub 2020 Mar 19 doi: 10.1007/s00415-020-09772-w. PMID: 32193596Free PMC Article
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article

Recent clinical studies

Etiology

Aljohani M, Yates J, Ashley M, O'Malley L
J Craniofac Surg 2021 Mar-Apr 01;32(2):505-508. doi: 10.1097/SCS.0000000000007071. PMID: 33704970
Maleki N, Tahaney K, Thompson BL, Oscar-Berman M
Neuropsychology 2019 Sep;33(6):795-807. doi: 10.1037/neu0000558. PMID: 31448947Free PMC Article
Peyron R, Fauchon C
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):38-45. Epub 2018 Oct 11 doi: 10.1016/j.neurol.2018.08.006. PMID: 30318262
Ramappa M, Chaurasia S, Chakrabarti S, Kaur I
J AAPOS 2014 Oct;18(5):427-32. Epub 2014 Oct 21 doi: 10.1016/j.jaapos.2014.05.011. PMID: 25439301
Ramaesh K, Stokes J, Henry E, Dutton GN, Dhillon B
Surv Ophthalmol 2007 Jan-Feb;52(1):50-60. doi: 10.1016/j.survophthal.2006.10.004. PMID: 17212990

Diagnosis

Örnek S, Zuberbier T, Kocatürk E
Clin Dermatol 2022 Sep-Oct;40(5):480-504. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.010. PMID: 34979264
Gasca-González OO, Pérez-Cruz JC, Baldoncini M, Macías-Duvignau MA, Delgado-Reyes L
Cir Cir 2020;88(3):376-382. doi: 10.24875/CIRU.19000801. PMID: 32539005
Wang VC, Mullally WJ
Am J Med 2020 Mar;133(3):273-280. Epub 2019 Aug 13 doi: 10.1016/j.amjmed.2019.07.029. PMID: 31419424
Rogers IS, Tremmel JA, Schnittger I
Congenit Heart Dis 2017 Sep;12(5):619-623. Epub 2017 Jul 3 doi: 10.1111/chd.12499. PMID: 28675696
Palmer J, Pontius E
Emerg Med Clin North Am 2016 May;34(2):409-23. Epub 2016 Mar 22 doi: 10.1016/j.emc.2015.12.007. PMID: 27133252

Therapy

Hussein H, Van Remoortel S, Boeckxstaens GE
Immunol Rev 2024 Sep;326(1):102-116. Epub 2024 Jul 22 doi: 10.1111/imr.13374. PMID: 39037230
Kurotschka PK, Gágyor I, Ebell MH
Am Fam Physician 2024 Feb;109(2):167-174. PMID: 38393801
Slouma M, Ben Dhia S, Cheour E, Gharsallah I
Curr Rheumatol Rev 2024;20(2):115-126. doi: 10.2174/0115733971254976230927113202. PMID: 37921132
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article
Roussos AP, Hirsch AR
Headache 2014 Feb;54(2):378-82. Epub 2013 Apr 1 doi: 10.1111/head.12091. PMID: 23551212

Prognosis

Maleki N, Tahaney K, Thompson BL, Oscar-Berman M
Neuropsychology 2019 Sep;33(6):795-807. doi: 10.1037/neu0000558. PMID: 31448947Free PMC Article
Rogers IS, Tremmel JA, Schnittger I
Congenit Heart Dis 2017 Sep;12(5):619-623. Epub 2017 Jul 3 doi: 10.1111/chd.12499. PMID: 28675696
Stone J, Vermeulen M
Handb Clin Neurol 2016;139:271-281. doi: 10.1016/B978-0-12-801772-2.00024-2. PMID: 27719847
Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J
Neurourol Urodyn 2008;27(4):306-10. doi: 10.1002/nau.20505. PMID: 17828787
Ramaesh K, Stokes J, Henry E, Dutton GN, Dhillon B
Surv Ophthalmol 2007 Jan-Feb;52(1):50-60. doi: 10.1016/j.survophthal.2006.10.004. PMID: 17212990

Clinical prediction guides

Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A
Surv Ophthalmol 2021 Jan-Feb;66(1):132-137. Epub 2020 Jun 5 doi: 10.1016/j.survophthal.2020.05.006. PMID: 32512032
Maleki N, Tahaney K, Thompson BL, Oscar-Berman M
Neuropsychology 2019 Sep;33(6):795-807. doi: 10.1037/neu0000558. PMID: 31448947Free PMC Article
Peyron R, Fauchon C
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):38-45. Epub 2018 Oct 11 doi: 10.1016/j.neurol.2018.08.006. PMID: 30318262
Staller K
J Clin Gastroenterol 2018 Jul;52(6):490-501. doi: 10.1097/MCG.0000000000001049. PMID: 29794543
Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J
Neurourol Urodyn 2008;27(4):306-10. doi: 10.1002/nau.20505. PMID: 17828787

Recent systematic reviews

Thielen H, Tuts N, Welkenhuyzen L, Huenges Wajer IMC, Lafosse C, Gillebert CR
J Neuropsychol 2023 Mar;17(1):1-31. Epub 2022 Jun 30 doi: 10.1111/jnp.12284. PMID: 35773750
Berwick RJ, Siew S, Andersson DA, Marshall A, Goebel A
J Pain 2021 May;22(5):473-486. Epub 2021 Jan 6 doi: 10.1016/j.jpain.2020.12.005. PMID: 33421589
Yin Y, He S, Xu J, You W, Li Q, Long J, Luo L, Kemp GJ, Sweeney JA, Li F, Chen S, Gong Q
J Headache Pain 2020 Jun 19;21(1):78. doi: 10.1186/s10194-020-01131-4. PMID: 32560622Free PMC Article
Aoki Y, Inokuchi R, Suwa H
Psychiatry Res 2013 Sep 30;213(3):242-8. Epub 2013 Jul 5 doi: 10.1016/j.pscychresns.2013.03.008. PMID: 23835064
Jeffcoate W, Lima J, Nobrega L
Diabet Med 2000 Apr;17(4):253-8. doi: 10.1046/j.1464-5491.2000.00233.x. PMID: 10821290

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...