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EEG with temporal focal spikes

MedGen UID:: 868670
•Concept ID:: C4023073
•: Finding

HPO:	HP:0012018

Definition

EEG with focal sharp transient waves of a duration less than 80 msec in the temporal region. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

EEG with temporal focal spikes

Abnormality of central nervous system electrophysiology
- EEG abnormality
  - Interictal EEG abnormality
    - Interictal epileptiform activity
      - EEG with focal epileptiform discharges
        EEG with temporal epileptiform discharges
        EEG with temporal focal spikes

Conditions with this feature

Intellectual disability, autosomal dominant 42

MedGen UID:: 934741
•Concept ID:: C4310774
•: Mental or Behavioral Dysfunction

GNB1 encephalopathy (GNB1-E) is characterized by moderate-to-severe developmental delay / intellectual disability, structural brain abnormalities, and often infantile hypotonia and seizures. Other less common findings include dystonia, reduced vision, behavior issues, growth delay, gastrointestinal (GI) problems, genitourinary (GU) abnormalities in males, and cutaneous mastocytosis.

See: Condition Record

Intellectual disability, autosomal dominant 42

Professional guidelines

PubMed

On the clinical utility of on-scalp MEG: A modeling study of epileptic activity source estimation.

Westin K, Beniczky S, Pfeiffer C, Hämäläinen M, Lundqvist D
Clin Neurophysiol 2023 Dec;156:143-155. Epub 2023 Oct 31 doi: 10.1016/j.clinph.2023.10.006. PMID: 37951041

Is there a place for surgical treatment of nonpharmacoresistant epilepsy?

Steinhoff BJ, Staack AM
Epilepsy Behav 2019 Feb;91:4-8. Epub 2018 Jun 28 doi: 10.1016/j.yebeh.2018.05.025. PMID: 29960857

Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes.

Tan HJ, Singh J, Gupta R, de Goede C
Cochrane Database Syst Rev 2014 Sep 5;2014(9):CD006779. doi: 10.1002/14651858.CD006779.pub2. PMID: 25190506 Free PMC Article

See all (9)

Recent clinical studies

Etiology

Surgery for epilepsy.

West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3. PMID: 31237346 Free PMC Article

Idiopathic focal epilepsies.

Vigevano F, Specchio N, Fejerman N
Handb Clin Neurol 2013;111:591-604. doi: 10.1016/B978-0-444-52891-9.00061-0. PMID: 23622206

Monitoring spike train synchrony.

Kreuz T, Chicharro D, Houghton C, Andrzejak RG, Mormann F
J Neurophysiol 2013 Mar;109(5):1457-72. Epub 2012 Dec 5 doi: 10.1152/jn.00873.2012. PMID: 23221419

Single-neuron dynamics in human focal epilepsy.

Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS
Nat Neurosci 2011 May;14(5):635-41. Epub 2011 Mar 27 doi: 10.1038/nn.2782. PMID: 21441925 Free PMC Article

Unusual EEG patterns.

Westmoreland BF, Klass DW
J Clin Neurophysiol 1990 Apr;7(2):209-28. doi: 10.1097/00004691-199004000-00005. PMID: 2187021

See all (287)

Diagnosis

Recognition of interictal and ictal discharges on EEG. Focal vs generalized epilepsy.

Andrade-Machado R, Benjumea Cuartas V, Muhammad IK
Epilepsy Behav 2021 Apr;117:107830. Epub 2021 Feb 25 doi: 10.1016/j.yebeh.2021.107830. PMID: 33639439

Surgery for epilepsy.

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

Idiopathic focal epilepsies.

Vigevano F, Specchio N, Fejerman N
Handb Clin Neurol 2013;111:591-604. doi: 10.1016/B978-0-444-52891-9.00061-0. PMID: 23622206

Magnetoencephalography in epilepsy.

Knowlton RC, Shih J
Epilepsia 2004;45 Suppl 4:61-71. doi: 10.1111/j.0013-9580.2004.04012.x. PMID: 15281961

See all (397)

Therapy

Neurosteroids and Focal Epileptic Disorders.

Lévesque M, Biagini G, Avoli M
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249391. PMID: 33321734 Free PMC Article

Surgery for epilepsy.

Is there a place for surgical treatment of nonpharmacoresistant epilepsy?

Steinhoff BJ, Staack AM
Epilepsy Behav 2019 Feb;91:4-8. Epub 2018 Jun 28 doi: 10.1016/j.yebeh.2018.05.025. PMID: 29960857

Surgery for epilepsy.

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

Sleep and epilepsy.

Dahl M, Dam M
Ann Clin Res 1985;17(5):235-42. PMID: 3936393

See all (129)

Prognosis

Surgery for epilepsy.

Is there a place for surgical treatment of nonpharmacoresistant epilepsy?

Steinhoff BJ, Staack AM
Epilepsy Behav 2019 Feb;91:4-8. Epub 2018 Jun 28 doi: 10.1016/j.yebeh.2018.05.025. PMID: 29960857

Surgery for epilepsy.

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

For things needing your attention: the role of neocortical gamma in sensory perception.

Pritchett DL, Siegle JH, Deister CA, Moore CI
Curr Opin Neurobiol 2015 Apr;31:254-63. Epub 2015 Mar 12 doi: 10.1016/j.conb.2015.02.004. PMID: 25770854

Idiopathic focal epilepsies.

Vigevano F, Specchio N, Fejerman N
Handb Clin Neurol 2013;111:591-604. doi: 10.1016/B978-0-444-52891-9.00061-0. PMID: 23622206

See all (207)

Clinical prediction guides

Focal seizures induce spatiotemporally organized spiking activity in the human cortex.

Diamond JM, Chapeton JI, Xie W, Jackson SN, Inati SK, Zaghloul KA
Nat Commun 2024 Aug 16;15(1):7075. doi: 10.1038/s41467-024-51338-1. PMID: 39152115 Free PMC Article

Surgery for epilepsy.

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

For things needing your attention: the role of neocortical gamma in sensory perception.

Pritchett DL, Siegle JH, Deister CA, Moore CI
Curr Opin Neurobiol 2015 Apr;31:254-63. Epub 2015 Mar 12 doi: 10.1016/j.conb.2015.02.004. PMID: 25770854

Current trends in electroencephalography.

Blume WT
Curr Opin Neurol 2001 Apr;14(2):193-7. doi: 10.1097/00019052-200104000-00010. PMID: 11262735

See all (274)

Recent systematic reviews

Spatio-temporal dynamics of interictal activity in musicogenic epilepsy: Two case reports and a systematic review of the literature.

Nuara A, Mirandola L, Fabbri-Destro M, Giovannini G, Vecchiato G, Vaudano AE, Tassinari CA, Avanzini P, Meletti S
Clin Neurophysiol 2020 Oct;131(10):2393-2401. Epub 2020 Jul 18 doi: 10.1016/j.clinph.2020.06.028. PMID: 32828042

Surgery for epilepsy.

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes.

Tan HJ, Singh J, Gupta R, de Goede C
Cochrane Database Syst Rev 2014 Sep 5;2014(9):CD006779. doi: 10.1002/14651858.CD006779.pub2. PMID: 25190506 Free PMC Article

See all (4)

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EEG with temporal focal spikes

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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