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Abnormal trabecular meshwork morphology

MedGen UID:
868420
•Concept ID:
C4022814
•
Anatomical Abnormality
Synonym: Abnormality of the trabecular meshwork
 
HPO: HP:0012630

Definition

An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal trabecular meshwork morphology

Professional guidelines

PubMed

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article
Congenital glaucoma--diagnosis and management.
Krieglstein GK
Trans Ophthalmol Soc U K (1962) 1986;105 ( Pt 5):549-54. PMID: 3541304
Management of secondary glaucoma in aniridia.
Panda A, Sood NN, Agarwal HC
Indian J Ophthalmol 1982 Jul;30(4):311-3. PMID: 7166413

Recent clinical studies

Etiology

Anterior segment dysgenesis: Insights into the genetics and pathogenesis.
Kaushik S, Dubey S, Choudhary S, Ratna R, Pandav SS, Khan AO
Indian J Ophthalmol 2022 Jul;70(7):2293-2303. doi: 10.4103/ijo.IJO_3223_21. PMID: 35791109Free PMC Article
Functional role of peroxiredoxin 6 in the eye.
Wahlig S, Lovatt M, Mehta JS
Free Radic Biol Med 2018 Oct;126:210-220. Epub 2018 Aug 16 doi: 10.1016/j.freeradbiomed.2018.08.017. PMID: 30120980
PLATEAU IRIS SYNDROME--CASE SERIES.
Feraru CI, Pantalon AD, Chiselita D, Branisteanu D
Rom J Ophthalmol 2015 Jul-Sep;59(3):188-93. PMID: 26978890Free PMC Article
Pigmentary glaucoma in the black population.
Semple HC, Ball SF
Am J Ophthalmol 1990 May 15;109(5):518-22. doi: 10.1016/s0002-9394(14)70680-4. PMID: 2333915
Glaucoma in children.
Chew E, Morin JD
Pediatr Clin North Am 1983 Dec;30(6):1043-60. doi: 10.1016/s0031-3955(16)34501-1. PMID: 6646864

Diagnosis

Anterior segment dysgenesis: Insights into the genetics and pathogenesis.
Kaushik S, Dubey S, Choudhary S, Ratna R, Pandav SS, Khan AO
Indian J Ophthalmol 2022 Jul;70(7):2293-2303. doi: 10.4103/ijo.IJO_3223_21. PMID: 35791109Free PMC Article
PLATEAU IRIS--DIAGNOSIS AND TREATMENT.
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article
Isolated right ventricular noncompaction in a newborn.
Sert A, Aypar E, Aslan E, Odabas D
Pediatr Cardiol 2013;34(8):1896-8. Epub 2012 Jul 19 doi: 10.1007/s00246-012-0435-0. PMID: 22810045
Pseudoexfoliation syndrome and pseudoexfoliative glaucoma.
Sowka J
Optometry 2004 Apr;75(4):245-50. doi: 10.1016/s1529-1839(04)70052-4. PMID: 15117058
Goniodysgenesis in exfoliation glaucoma.
Jerndal T, Svedbergh B
Adv Ophthalmol 1978;35:45-64. PMID: 415529

Therapy

Oxidative stress in the trabecular meshwork (Review).
Zhao J, Wang S, Zhong W, Yang B, Sun L, Zheng Y
Int J Mol Med 2016 Oct;38(4):995-1002. Epub 2016 Aug 24 doi: 10.3892/ijmm.2016.2714. PMID: 27572245
Pseudoexfoliation syndrome and pseudoexfoliative glaucoma.
Sowka J
Optometry 2004 Apr;75(4):245-50. doi: 10.1016/s1529-1839(04)70052-4. PMID: 15117058
Exfoliation syndrome.
Lin YJ, Wang TH, Kao SC, Hung PT
J Formos Med Assoc 1996 Mar;95(3):263-6. PMID: 8857263
Experimental models of anterior segment dysgenesis.
Cook CS
Ophthalmic Paediatr Genet 1989 Mar;10(1):33-46. doi: 10.3109/13816818909083771. PMID: 2662095
Glaucoma in children.
Chew E, Morin JD
Pediatr Clin North Am 1983 Dec;30(6):1043-60. doi: 10.1016/s0031-3955(16)34501-1. PMID: 6646864

Prognosis

Primary congenital glaucoma: An iridotrabeculodysgenesis?
Sihota R, Mahalingam K, Maurya AK, Sharma A, Bukke AN, Dada T
Indian J Ophthalmol 2024 Mar 1;72(3):328-334. Epub 2023 Dec 15 doi: 10.4103/IJO.IJO_370_23. PMID: 38099353Free PMC Article
Pigment dispersion syndrome and pigmentary glaucoma: a review and update.
Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842
Isolated right ventricular noncompaction in a newborn.
Sert A, Aypar E, Aslan E, Odabas D
Pediatr Cardiol 2013;34(8):1896-8. Epub 2012 Jul 19 doi: 10.1007/s00246-012-0435-0. PMID: 22810045
Primary glaucoma associated with iridotrabecular dysgenesis and ectropion uveae.
Dowling JL Jr, Albert DM, Nelson LB, Walton DS
Ophthalmology 1985 Jul;92(7):912-21. doi: 10.1016/s0161-6420(85)33935-0. PMID: 4022577
Congenital, infantile, and juvenile glaucoma.
Luntz MH
Ophthalmology 1979 May;86(5):793-802. doi: 10.1016/s0161-6420(79)35451-3. PMID: 545209

Clinical prediction guides

Oxidative stress in the trabecular meshwork (Review).
Zhao J, Wang S, Zhong W, Yang B, Sun L, Zheng Y
Int J Mol Med 2016 Oct;38(4):995-1002. Epub 2016 Aug 24 doi: 10.3892/ijmm.2016.2714. PMID: 27572245
A common pathway for developmental glaucomas.
Shields MB
Trans Am Ophthalmol Soc 1987;85:222-37. PMID: 3328916Free PMC Article
Anatomical classification of the developmental glaucomas.
Hoskins HD Jr, Shaffer RN, Hetherington J
Arch Ophthalmol 1984 Sep;102(9):1331-6. doi: 10.1001/archopht.1984.01040031081030. PMID: 6477252
Hallermann-Streiff-Francois syndrome.
Aracena T, Sangueza P
J Pediatr Ophthalmol 1977 Nov-Dec;14(6):373-8. PMID: 604445
Ocular changes in epidermolysis bullosa letalis.
Aurora AL, Madhavan M, Rao S
Am J Ophthalmol 1975 Mar;79(3):464-70. doi: 10.1016/0002-9394(75)90623-6. PMID: 1122001

Recent systematic reviews

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article

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