U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

METACHROMATIC LEUKODYSTROPHY, MILD

MedGen UID:
866284
Concept ID:
C4017847
Finding
OMIM®: 607574

Recent clinical studies

Etiology

Schoenmakers DH, Beerepoot S, Krägeloh-Mann I, Elgün S, Bender B, van der Knaap MS, Wolf NI, Groeschel S
Ann Clin Transl Neurol 2022 Dec;9(12):1999-2009. Epub 2022 Nov 5 doi: 10.1002/acn3.51692. PMID: 36334091Free PMC Article
Fumagalli F, Zambon AA, Rancoita PMV, Baldoli C, Canale S, Spiga I, Medaglini S, Penati R, Facchini M, Ciotti F, Sarzana M, Lorioli L, Cesani M, Natali Sora MG, Del Carro U, Cugnata F, Antonioli G, Recupero S, Calbi V, Di Serio C, Aiuti A, Biffi A, Sessa M
J Inherit Metab Dis 2021 Sep;44(5):1151-1164. Epub 2021 May 4 doi: 10.1002/jimd.12388. PMID: 33855715
Bascou NA, Marcos MC, Beltran Quintero ML, Roosen-Marcos MC, Cladis FP, Poe MD, Escolar ML
Paediatr Anaesth 2019 Oct;29(10):1053-1059. Epub 2019 Sep 4 doi: 10.1111/pan.13714. PMID: 31359511
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J; ARUK Consortium, Blumenau S, Thielke M, Josties C, Freyer D, Dietrich A, Hammer M, Baier M, Dirnagl U, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hodges A, Hardy J
Neurobiol Aging 2018 Jun;66:179.e17-179.e29. Epub 2018 Feb 2 doi: 10.1016/j.neurobiolaging.2018.01.015. PMID: 29544907Free PMC Article
Chen X, Gill D, Shaw P, Ouvrier R, Troedson C
J Child Neurol 2016 Mar;31(3):338-44. Epub 2015 Jul 17 doi: 10.1177/0883073815595078. PMID: 26187619

Diagnosis

Olivé-Cirera G, Martínez-González MJ, Armangué T
Neurology 2022 Nov 7;99(19):858-861. doi: 10.1212/WNL.0000000000201230. PMID: 36041866
Fumagalli F, Zambon AA, Rancoita PMV, Baldoli C, Canale S, Spiga I, Medaglini S, Penati R, Facchini M, Ciotti F, Sarzana M, Lorioli L, Cesani M, Natali Sora MG, Del Carro U, Cugnata F, Antonioli G, Recupero S, Calbi V, Di Serio C, Aiuti A, Biffi A, Sessa M
J Inherit Metab Dis 2021 Sep;44(5):1151-1164. Epub 2021 May 4 doi: 10.1002/jimd.12388. PMID: 33855715
Singhal BS
Indian J Pediatr 2005 Apr;72(4):315-8. doi: 10.1007/BF02724013. PMID: 15876760
Barkovich AJ
AJNR Am J Neuroradiol 2000 Jun-Jul;21(6):1099-109. PMID: 10871022Free PMC Article
Gieselmann V, Polten A, Kreysing J, von Figura K
J Inherit Metab Dis 1994;17(4):500-9. doi: 10.1007/BF00711364. PMID: 7967499

Therapy

Al-Saady M, Beerepoot S, Plug BC, Breur M, Galabova H, Pouwels PJW, Boelens JJ, Lindemans C, van Hasselt PM, Matzner U, Vanderver A, Bugiani M, van der Knaap MS, Wolf NI
Ann Clin Transl Neurol 2023 Jul;10(7):1146-1159. Epub 2023 May 22 doi: 10.1002/acn3.51796. PMID: 37212343Free PMC Article
Meneghini V, Lattanzi A, Tiradani L, Bravo G, Morena F, Sanvito F, Calabria A, Bringas J, Fisher-Perkins JM, Dufour JP, Baker KC, Doglioni C, Montini E, Bunnell BA, Bankiewicz K, Martino S, Naldini L, Gritti A
EMBO Mol Med 2016 May;8(5):489-510. Epub 2016 May 2 doi: 10.15252/emmm.201505850. PMID: 27025653Free PMC Article
Stein A, Stroobants S, Gieselmann V, D'Hooge R, Matzner U
Mol Ther 2015 Jul;23(7):1160-1168. Epub 2015 Apr 21 doi: 10.1038/mt.2015.69. PMID: 25896249Free PMC Article
Herz B, Bach G
Hum Genet 1984;66(2-3):147-50. doi: 10.1007/BF00286589. PMID: 6143719

Prognosis

Al-Saady M, Beerepoot S, Plug BC, Breur M, Galabova H, Pouwels PJW, Boelens JJ, Lindemans C, van Hasselt PM, Matzner U, Vanderver A, Bugiani M, van der Knaap MS, Wolf NI
Ann Clin Transl Neurol 2023 Jul;10(7):1146-1159. Epub 2023 May 22 doi: 10.1002/acn3.51796. PMID: 37212343Free PMC Article
Fumagalli F, Zambon AA, Rancoita PMV, Baldoli C, Canale S, Spiga I, Medaglini S, Penati R, Facchini M, Ciotti F, Sarzana M, Lorioli L, Cesani M, Natali Sora MG, Del Carro U, Cugnata F, Antonioli G, Recupero S, Calbi V, Di Serio C, Aiuti A, Biffi A, Sessa M
J Inherit Metab Dis 2021 Sep;44(5):1151-1164. Epub 2021 May 4 doi: 10.1002/jimd.12388. PMID: 33855715
Verberne EA, Dalen Meurs L, Wolf NI, van Haelst MM
Am J Med Genet A 2020 Jul;182(7):1776-1779. Epub 2020 Apr 22 doi: 10.1002/ajmg.a.61600. PMID: 32319736Free PMC Article
Chen X, Gill D, Shaw P, Ouvrier R, Troedson C
J Child Neurol 2016 Mar;31(3):338-44. Epub 2015 Jul 17 doi: 10.1177/0883073815595078. PMID: 26187619
Wang PJ, Hwu WL, Shen YZ
J Clin Neurophysiol 2001 Jan;18(1):25-32. doi: 10.1097/00004691-200101000-00006. PMID: 11290936

Clinical prediction guides

Schoenmakers DH, Beerepoot S, Krägeloh-Mann I, Elgün S, Bender B, van der Knaap MS, Wolf NI, Groeschel S
Ann Clin Transl Neurol 2022 Dec;9(12):1999-2009. Epub 2022 Nov 5 doi: 10.1002/acn3.51692. PMID: 36334091Free PMC Article
Fumagalli F, Zambon AA, Rancoita PMV, Baldoli C, Canale S, Spiga I, Medaglini S, Penati R, Facchini M, Ciotti F, Sarzana M, Lorioli L, Cesani M, Natali Sora MG, Del Carro U, Cugnata F, Antonioli G, Recupero S, Calbi V, Di Serio C, Aiuti A, Biffi A, Sessa M
J Inherit Metab Dis 2021 Sep;44(5):1151-1164. Epub 2021 May 4 doi: 10.1002/jimd.12388. PMID: 33855715
Schlotawa L, Steinfeld R, von Figura K, Dierks T, Gärtner J
Hum Mutat 2008 Jan;29(1):205. doi: 10.1002/humu.9515. PMID: 18157819
Gieselmann V
Acta Paediatr Suppl 2005 Mar;94(447):80-6; discussion 79. doi: 10.1111/j.1651-2227.2005.tb02118.x. PMID: 15895717
Wang PJ, Hwu WL, Shen YZ
J Clin Neurophysiol 2001 Jan;18(1):25-32. doi: 10.1097/00004691-200101000-00006. PMID: 11290936

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • AAP, 2021
      Leukodystrophies in Children: Diagnosis, Care, and Treatment, Pediatrics (2021) 148 (3): e2021053126.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...