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DIABETES MELLITUS, TYPE II, DIGENIC

MedGen UID:
866066
•Concept ID:
C4017629
•
Finding
Synonym: TYPE 2 DIABETES MELLITUS, DIGENIC
 
OMIM®: 600917

Professional guidelines

PubMed

Molecular genetic testing of patients with monogenic diabetes and hyperinsulinism.
Bennett JT, Vasta V, Zhang M, Narayanan J, Gerrits P, Hahn SH
Mol Genet Metab 2015 Mar;114(3):451-8. Epub 2014 Dec 20 doi: 10.1016/j.ymgme.2014.12.304. PMID: 25555642Free PMC Article

Curated

UK NICE Guideline NG19, Diabetic foot problems: prevention and management, 2019

Recent clinical studies

Etiology

The CARDINAL Trial of Bardoxolone Methyl in Alport Syndrome: When Marketing Interests Prevail over Patients Clinical Needs.
Ruggenenti P
Nephron 2023;147(8):465-469. Epub 2023 Feb 2 doi: 10.1159/000529471. PMID: 36731435
PSMD9 is linked to MODY3.
Gragnoli C
J Cell Physiol 2010 Apr;223(1):1-5. doi: 10.1002/jcp.22007. PMID: 20069546
High frequency of mutations in the HNF-1alpha gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance.
Tonooka N, Tomura H, Takahashi Y, Onigata K, Kikuchi N, Horikawa Y, Mori M, Takeda J
Diabetologia 2002 Dec;45(12):1709-12. Epub 2002 Nov 16 doi: 10.1007/s00125-002-0978-3. PMID: 12488961

Diagnosis

An Italian MODY family with proband and son carrying variants in GCK and HFN1A: is it a true case of digenic MODY?
Lucchesi D, Randazzo E, Del Prato S, Bianchi C
Acta Diabetol 2024 Jan;61(1):131-134. Epub 2023 Sep 20 doi: 10.1007/s00592-023-02171-3. PMID: 37730861
A case of digenic maturity onset diabetes of the young with heterozygous variants in both HNF1Α and HNF1Β genes.
Patouni K, Cinek O, Pruhova S, Elblova L, Xatzipsalti M, Sertedaki A, Vazeou A
Eur J Med Genet 2021 Sep;64(9):104264. Epub 2021 Jun 20 doi: 10.1016/j.ejmg.2021.104264. PMID: 34161864
Molecular genetic testing of patients with monogenic diabetes and hyperinsulinism.
Bennett JT, Vasta V, Zhang M, Narayanan J, Gerrits P, Hahn SH
Mol Genet Metab 2015 Mar;114(3):451-8. Epub 2014 Dec 20 doi: 10.1016/j.ymgme.2014.12.304. PMID: 25555642Free PMC Article
Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes.
Shankar RK, Ellard S, Standiford D, Pihoker C, Gilliam LK, Hattersley A, Dolan LM
Pediatr Diabetes 2013 Nov;14(7):535-8. Epub 2013 Mar 31 doi: 10.1111/pedi.12018. PMID: 23551881Free PMC Article
High frequency of mutations in the HNF-1alpha gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance.
Tonooka N, Tomura H, Takahashi Y, Onigata K, Kikuchi N, Horikawa Y, Mori M, Takeda J
Diabetologia 2002 Dec;45(12):1709-12. Epub 2002 Nov 16 doi: 10.1007/s00125-002-0978-3. PMID: 12488961

Therapy

The CARDINAL Trial of Bardoxolone Methyl in Alport Syndrome: When Marketing Interests Prevail over Patients Clinical Needs.
Ruggenenti P
Nephron 2023;147(8):465-469. Epub 2023 Feb 2 doi: 10.1159/000529471. PMID: 36731435
Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes.
Shankar RK, Ellard S, Standiford D, Pihoker C, Gilliam LK, Hattersley A, Dolan LM
Pediatr Diabetes 2013 Nov;14(7):535-8. Epub 2013 Mar 31 doi: 10.1111/pedi.12018. PMID: 23551881Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Guideline NG19, Diabetic foot problems: prevention and management, 2019

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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