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Tolbutamide response

MedGen UID:: 865155
•Concept ID:: C4016718
•: Finding

Synonym:	Tolbutamide poor metabolizer
Drug:	Tolbutamide MedGen UID: 21577 •Concept ID: C0040374 • Pharmacologic Substance A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29. [from NCI] Tolbutamide

Gene (location): Gene(s) directly associated with this condition or phenotype.	G6PD (Xq28)

OMIM®:	601130

Professional guidelines

PubMed

Warfarin-fluconazole. III. A rational approach to management of a metabolically based drug interaction.

Kunze KL, Trager WF
Drug Metab Dispos 1996 Apr;24(4):429-35. PMID: 8801058

Hypernatremia due to hypodipsia and elevated threshold for vasopressin release. Effects of treatment with hydrochlorothiazide, chlorpropamide and tolbutamide.

Mahoney JH, Goodman AD
N Engl J Med 1968 Nov 28;279(22):1191-6. doi: 10.1056/NEJM196811282792203. PMID: 4301177

Pustular acne, staphyloderma and its treatment with tolbutamide.

COHEN JL, COHEN AD
Can Med Assoc J 1958 Apr 15;80(8):629-32. PMID: 13638929 Free PMC Article

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Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Intravenous tolbutamide response test in the diagnosis of diabetes mellitus.

Limaye SB, Deshmukh PY, Nawaz M
J Assoc Physicians India 1970 Feb;18(2):269-74. PMID: 5423038

The intravenous tolbutamide response in the diagnosis of diabetes.

Walker RL
Med J Aust 1968 Jul 27;2(4):164-6. doi: 10.5694/j.1326-5377.1968.tb29380.x. PMID: 5670885

Comparison of intravenous glucose tolerance and intravenous tolbutamide response in ischemic cardiovascular disease.

Hagenfeldt L, Wahlberg F
Diabetes 1967 Jan;16(1):15-7. doi: 10.2337/diab.16.1.15. PMID: 6015677

Oral tolbutamide response test in the diagnosis of diabetes mellitus.

Massey RU
Henry Ford Hosp Med J 1966 Mar;14(1):31-41. PMID: 5909041

The intravenous tolbutamide response test in the diagnosis of mild diabetes.

UNGER RH, MADISON LL
Ann N Y Acad Sci 1959 Mar 30;74(3):667-71. doi: 10.1111/j.1749-6632.1959.tb39593.x. PMID: 13637606

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Therapy

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

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Clinical prediction guides

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

The intravenous tolbutamide response test. Initial observations.

WHITEHOUSE FW, LOWRIE WL
J Mich State Med Soc 1960 Oct;59:1540-42. PMID: 13784885

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Tolbutamide response

Professional guidelines

PubMed

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Therapy

Clinical prediction guides

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