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Atrial fibrillation, familial, 16(ATFB16)

MedGen UID:
862136
Concept ID:
C4013699
Finding
Synonym: ATFB16
 
Monarch Initiative: MONDO:0800349
OMIM®: 608214; 613120

Definition

Familial atrial fibrillation is an inherited abnormality of the heart's normal rhythm. Atrial fibrillation is characterized by episodes of uncoordinated electrical activity (fibrillation) in the heart's upper chambers (the atria), which cause a fast and irregular heartbeat. If untreated, this abnormal heart rhythm (arrhythmia) can lead to dizziness, chest pain, a sensation of fluttering or pounding in the chest (palpitations), shortness of breath, or fainting (syncope). Atrial fibrillation also increases the risk of stroke and sudden death. Complications of atrial fibrillation can occur at any age, although some people with this heart condition never experience any health problems associated with the disorder. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Alkhouli M, Alarouri H, Kramer A, Korsholm K, Collins J, De Backer O, Hatoum H, Nielsen-Kudsk JE
JACC Cardiovasc Interv 2023 Nov 27;16(22):2695-2707. doi: 10.1016/j.jcin.2023.10.046. PMID: 38030357
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Mendelson SJ, Prabhakaran S
JAMA 2021 Mar 16;325(11):1088-1098. doi: 10.1001/jama.2020.26867. PMID: 33724327

Curated

UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

Recent clinical studies

Etiology

Potpara T
EuroIntervention 2024 Aug 19;20(16):961-3. doi: 10.4244/EIJ-E-24-00043. PMID: 39230004Free PMC Article
Leszto K, Frąk W, Kurciński S, Sinkowska J, Skwira S, Młynarska E, Rysz J, Franczyk B
Nutrients 2024 Feb 5;16(3) doi: 10.3390/nu16030456. PMID: 38337740Free PMC Article
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Chung MK, Eckhardt LL, Chen LY, Ahmed HM, Gopinathannair R, Joglar JA, Noseworthy PA, Pack QR, Sanders P, Trulock KM; American Heart Association Electrocardiography and Arrhythmias Committee and Exercise, Cardiac Rehabilitation, and Secondary Prevention Committee of the Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Lifestyle and Cardiometabolic Health
Circulation 2020 Apr 21;141(16):e750-e772. Epub 2020 Mar 9 doi: 10.1161/CIR.0000000000000748. PMID: 32148086
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article

Diagnosis

Potpara T
EuroIntervention 2024 Aug 19;20(16):961-3. doi: 10.4244/EIJ-E-24-00043. PMID: 39230004Free PMC Article
Alkhouli M, Alarouri H, Kramer A, Korsholm K, Collins J, De Backer O, Hatoum H, Nielsen-Kudsk JE
JACC Cardiovasc Interv 2023 Nov 27;16(22):2695-2707. doi: 10.1016/j.jcin.2023.10.046. PMID: 38030357
Antman EM, Leopold JA, Sauer WH, Zei PC
N Engl J Med 2022 Oct 20;387(16):e38. doi: 10.1056/NEJMp2212939. PMID: 36260791
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article

Therapy

O'Brien B, Campbell NG, Allen E, Jamal Z, Sturgess J, Sanders J, Opondo C, Roberts N, Aron J, Maccaroni MR, Gould R, Kirmani BH, Gibbison B, Kunst G, Zarbock A, Kleine-Brüggeney M, Stoppe C, Pearce K, Hughes M, Van Dyck L, Evans R, Montgomery HE, Elbourne D; TIGHT K investigators
JAMA 2024 Sep 24;332(12):979-988. doi: 10.1001/jama.2024.17888. PMID: 39215972Free PMC Article
Antman EM, Leopold JA, Sauer WH, Zei PC
N Engl J Med 2022 Oct 20;387(16):e38. doi: 10.1056/NEJMp2212939. PMID: 36260791
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Lan Q, Wu F, Han B, Ma L, Han J, Yao Y
Am J Emerg Med 2022 Jan;51:248-256. Epub 2021 Nov 6 doi: 10.1016/j.ajem.2021.08.082. PMID: 34781150
Guo Y, Lane DA, Wang L, Zhang H, Wang H, Zhang W, Wen J, Xing Y, Wu F, Xia Y, Liu T, Wu F, Liang Z, Liu F, Zhao Y, Li R, Li X, Zhang L, Guo J, Burnside G, Chen Y, Lip GYH; mAF-App II Trial Investigators
J Am Coll Cardiol 2020 Apr 7;75(13):1523-1534. doi: 10.1016/j.jacc.2020.01.052. PMID: 32241367

Prognosis

Zhang W, Liang J, Li C, Gao D, Ma Q, Pan Y, Wang Y, Xie W, Zheng F
JAMA Netw Open 2023 Nov 1;6(11):e2342744. doi: 10.1001/jamanetworkopen.2023.42744. PMID: 37938842Free PMC Article
Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Guha A, Fradley MG, Dent SF, Weintraub NL, Lustberg MB, Alonso A, Addison D
Eur Heart J 2022 Jan 31;43(4):300-312. doi: 10.1093/eurheartj/ehab745. PMID: 34791123Free PMC Article
Lippi G, Sanchis-Gomar F, Cervellin G
Int J Stroke 2021 Feb;16(2):217-221. Epub 2020 Jan 19 doi: 10.1177/1747493019897870. PMID: 31955707
Dell'Orfano JT, Naccarelli GV
Curr Opin Cardiol 2001 Jan;16(1):54-7. doi: 10.1097/00001573-200101000-00008. PMID: 11124719

Clinical prediction guides

Nagueh SF
JACC Cardiovasc Imaging 2023 Nov;16(11):1384-1386. Epub 2023 Aug 9 doi: 10.1016/j.jcmg.2023.07.003. PMID: 37565962
Nagueh SF, Khan SU
JACC Cardiovasc Imaging 2023 May;16(5):691-707. Epub 2023 Jan 11 doi: 10.1016/j.jcmg.2022.10.011. PMID: 36752445
Louka AM, Tsagkaris C, Stoica A
Rom J Intern Med 2021 Dec 1;59(4):321-327. Epub 2021 Nov 20 doi: 10.2478/rjim-2021-0018. PMID: 33951355
Poorthuis MHF, Jones NR, Sherliker P, Clack R, de Borst GJ, Clarke R, Lewington S, Halliday A, Bulbulia R
Eur J Prev Cardiol 2021 May 22;28(6):586-595. doi: 10.1093/eurjpc/zwaa082. PMID: 33624100Free PMC Article
Galvez-Olortegui JK, Álvarez-Vargas ML, Galvez-Olortegui TV, Godoy-Palomino A, Camacho-Saavedra L
Medwave 2016 Jan 14;16(1):e6365. doi: 10.5867/medwave.2016.01.6365. PMID: 26939036

Recent systematic reviews

McDonagh ST, Dalal H, Moore S, Clark CE, Dean SG, Jolly K, Cowie A, Afzal J, Taylor RS
Cochrane Database Syst Rev 2023 Oct 27;10(10):CD007130. doi: 10.1002/14651858.CD007130.pub5. PMID: 37888805Free PMC Article
Steinmetz C, Bjarnason-Wehrens B, Walther T, Schaffland TF, Walther C
Am J Phys Med Rehabil 2023 Apr 1;102(4):323-330. Epub 2022 Sep 23 doi: 10.1097/PHM.0000000000002097. PMID: 36149383Free PMC Article
Lan Q, Wu F, Han B, Ma L, Han J, Yao Y
Am J Emerg Med 2022 Jan;51:248-256. Epub 2021 Nov 6 doi: 10.1016/j.ajem.2021.08.082. PMID: 34781150
Ramesh T, Lee PYK, Mitta M, Allencherril J
J Cardiol 2021 Nov;78(5):375-381. Epub 2021 Jun 20 doi: 10.1016/j.jjcc.2021.06.001. PMID: 34162502
Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH
Stroke 2018 Jan;49(1):98-106. Epub 2017 Nov 22 doi: 10.1161/STROKEAHA.117.018395. PMID: 29167388

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021