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Hyper-IgE syndrome(HIES1)

MedGen UID:
854488
Concept ID:
C3887645
Disease or Syndrome
Synonym: Hyper-IgE recurrent infection syndrome
SNOMED CT: HIE syndrome (50926003); Job syndrome (50926003); Quie-Hill syndrome (50926003); Buckley's syndrome (50926003); Job-Buckley syndrome (50926003); Hyperimmunoglobulin E syndrome (50926003); Job's syndrome (50926003); Recurring cold staphylococcal abscesses (50926003)
 
Monarch Initiative: MONDO:0018037
OMIM®: 102582; 147060
OMIM® Phenotypic series: PS147060
Orphanet: ORPHA331223

Definition

A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections. [from NCI]

Professional guidelines

PubMed

Sabbagh Q, Cohen JD, Mortreux J, Raymond L, Geromel V, Boursier G, Jeziorski E, Le Moing V, Bessis D, Geneviève D
Dermatitis 2023 Nov-Dec;34(6):561-563. Epub 2023 Jan 19 doi: 10.1089/derm.2022.0057. PMID: 36917542
Wu PC, Dai YX, Li CL, Chen CC, Chang YT, Ma SH
J Dtsch Dermatol Ges 2023 Jan;21(1):7-17. Epub 2023 Jan 19 doi: 10.1111/ddg.14924. PMID: 36657040
Flinn AM, Cant A, Leahy TR, Butler KM, Gennery AR
J Clin Immunol 2016 Feb;36(2):107-9. Epub 2016 Jan 7 doi: 10.1007/s10875-015-0231-8. PMID: 26743515

Recent clinical studies

Etiology

Schwierzeck V, Effner R, Abel F, Reiger M, Notheis G, Held J, Simon V, Dintner S, Hoffmann R, Hagl B, Huebner J, Mellmann A, Renner ED
J Clin Immunol 2022 Aug;42(6):1301-1309. Epub 2022 Jun 2 doi: 10.1007/s10875-022-01293-7. PMID: 35655107Free PMC Article
Lachover-Roth I, Lagovsky I, Shtorch-Asor A, Confino-Cohen R, Reinstein E, Garty BZ
Front Immunol 2022;13:829239. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.829239. PMID: 35185921Free PMC Article
Tsilifis C, Freeman AF, Gennery AR
J Clin Immunol 2021 Jul;41(5):864-880. Epub 2021 May 1 doi: 10.1007/s10875-021-01051-1. PMID: 33932191Free PMC Article
Al-Shaikhly T, Ochs HD
Immunol Cell Biol 2019 Apr;97(4):368-379. Epub 2018 Nov 19 doi: 10.1111/imcb.12209. PMID: 30264496
Green L, Dolen WK
Curr Allergy Asthma Rep 2017 May;17(5):31. doi: 10.1007/s11882-017-0699-9. PMID: 28429308

Diagnosis

Grenier PA, Brun AL, Longchampt E, Lipski M, Mellot F, Catherinot E
Eur Radiol 2024 Jun;34(6):4142-4154. Epub 2023 Nov 8 doi: 10.1007/s00330-023-10334-7. PMID: 37935849Free PMC Article
Sabbagh Q, Cohen JD, Mortreux J, Raymond L, Geromel V, Boursier G, Jeziorski E, Le Moing V, Bessis D, Geneviève D
Dermatitis 2023 Nov-Dec;34(6):561-563. Epub 2023 Jan 19 doi: 10.1089/derm.2022.0057. PMID: 36917542
Lachover-Roth I, Lagovsky I, Shtorch-Asor A, Confino-Cohen R, Reinstein E, Garty BZ
Front Immunol 2022;13:829239. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.829239. PMID: 35185921Free PMC Article
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396Free PMC Article
Al-Shaikhly T, Ochs HD
Immunol Cell Biol 2019 Apr;97(4):368-379. Epub 2018 Nov 19 doi: 10.1111/imcb.12209. PMID: 30264496

Therapy

Staudacher O, Krüger R, Kölsch U, Thee S, Gratopp A, Wahn V, Lau S, von Bernuth H
J Allergy Clin Immunol Pract 2022 Jan;10(1):349-351.e1. Epub 2021 Sep 16 doi: 10.1016/j.jaip.2021.08.042. PMID: 34536614
Eigenmann P
Pediatr Allergy Immunol 2019 Jun;30(4):403-404. doi: 10.1111/pai.13062. PMID: 31144359
Chia JC, Mydlarski PR
J Dermatolog Treat 2017 Jun;28(4):332-337. Epub 2016 Nov 7 doi: 10.1080/09546634.2016.1249819. PMID: 27759482
Lyons JJ, Milner JD, Stone KD
Immunol Allergy Clin North Am 2015 Feb;35(1):161-83. Epub 2014 Nov 21 doi: 10.1016/j.iac.2014.09.008. PMID: 25459583Free PMC Article
Ling Y, Puel A
Actas Dermosifiliogr 2014 Oct;105 Suppl 1:34-40. doi: 10.1016/S0001-7310(14)70016-X. PMID: 25398490

Prognosis

Chen YH, van Zon S, Adams A, Schmidt-Arras D, Laurence ADJ, Uhlig HH
J Clin Immunol 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7. PMID: 38133879Free PMC Article
Zhong J, Qiu M, Meng Y, Wang P, Chen S, Wang L
Int Immunopharmacol 2023 Sep;122:110624. Epub 2023 Jul 21 doi: 10.1016/j.intimp.2023.110624. PMID: 37480751
Zou P, Tang R, Chen P, Qiu X, Zhang G, Zhan Y, Xiao R
Acta Derm Venereol 2019 Jun 1;99(7):697-698. doi: 10.2340/00015555-3182. PMID: 30896777
Olbrich P, Freeman AF
Expert Rev Clin Immunol 2018 Dec;14(12):1029-1041. Epub 2018 Oct 25 doi: 10.1080/1744666X.2018.1531704. PMID: 30280610
Stentzel S, Hagl B, Abel F, Kahl BC, Rack-Hoch A, Bröker BM, Renner ED
Clin Infect Dis 2017 May 1;64(9):1279-1282. doi: 10.1093/cid/cix140. PMID: 28203787

Clinical prediction guides

Grenier PA, Brun AL, Longchampt E, Lipski M, Mellot F, Catherinot E
Eur Radiol 2024 Jun;34(6):4142-4154. Epub 2023 Nov 8 doi: 10.1007/s00330-023-10334-7. PMID: 37935849Free PMC Article
Miyauchi K, Ki S, Ukai M, Suzuki Y, Inoue K, Suda W, Matsui T, Ito Y, Honda K, Koseki H, Ohara O, Tanaka RJ, Okada-Hatakeyama M, Kubo M
Front Immunol 2021;12:663177. Epub 2021 Nov 11 doi: 10.3389/fimmu.2021.663177. PMID: 34867936Free PMC Article
Ling Y, Puel A
Actas Dermosifiliogr 2014 Oct;105 Suppl 1:34-40. doi: 10.1016/S0001-7310(14)70016-X. PMID: 25398490
Su HC, Jing H, Zhang Q
Ann N Y Acad Sci 2011 Dec;1246:26-33. doi: 10.1111/j.1749-6632.2011.06295.x. PMID: 22236427
Minegishi Y
Curr Opin Immunol 2009 Oct;21(5):487-92. Epub 2009 Aug 28 doi: 10.1016/j.coi.2009.07.013. PMID: 19717292

Recent systematic reviews

Mohammadi T, Azizi G, Rafiemanesh H, Farahani P, Nirouei M, Tavakol M
Clin Exp Med 2023 Dec;23(8):4835-4859. Epub 2023 Nov 4 doi: 10.1007/s10238-023-01228-5. PMID: 37924455
Wu PC, Dai YX, Li CL, Chen CC, Chang YT, Ma SH
J Dtsch Dermatol Ges 2023 Jan;21(1):7-17. Epub 2023 Jan 19 doi: 10.1111/ddg.14924. PMID: 36657040
Delplanque M, Galicier L, Oziol E, Ducharme-Bénard S, Oksenhendler E, Buob D, Grateau G, Boutboul D, Georgin-Lavialle S
J Allergy Clin Immunol Pract 2021 Feb;9(2):745-752.e1. Epub 2020 Sep 30 doi: 10.1016/j.jaip.2020.09.023. PMID: 33007500

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