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Graft-versus-host disease, resistance to

MedGen UID:
482308
•Concept ID:
C3280678
•
Finding
Synonym: GRAFT-VERSUS-HOST DISEASE, RESISTANCE TO
 
OMIM®: 124092; 614395

Professional guidelines

PubMed

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485
Long-term follow-up of a phase 3 clinical trial of inolimomab for the treatment of primary steroid refractory aGVHD.
Socié G, Milpied N, Yakoub-Agha I, Bay JO, Fürst S, Bilger K, Suarez F, Michallet M, Lewalle P, Liens D, Mathis C, Guemas E, Vernant JP
Blood Adv 2019 Jan 22;3(2):184-186. doi: 10.1182/bloodadvances.2018028282. PMID: 30670534Free PMC Article
Intra-arterial methylprednisolone for the management of steroid-refractory acute gastrointestinal and hepatic graft versus host disease.
Milner LA, Becker MW, Bernstein SH, Bruckner L, Friedberg JW, Holland GA, Ifthikharuddin JJ, Liesveld JL, Mathes EJ, Menchel HL, Mullen CA, Sasson T, Phillips GL 2nd
Am J Hematol 2011 Aug;86(8):712-4. Epub 2011 May 31 doi: 10.1002/ajh.22075. PMID: 21630317

Recent clinical studies

Etiology

An enterococcal phage-derived enzyme suppresses graft-versus-host disease.
Fujimoto K, Hayashi T, Yamamoto M, Sato N, Shimohigoshi M, Miyaoka D, Yokota C, Watanabe M, Hisaki Y, Kamei Y, Yokoyama Y, Yabuno T, Hirose A, Nakamae M, Nakamae H, Uematsu M, Sato S, Yamaguchi K, Furukawa Y, Akeda Y, Hino M, Imoto S, Uematsu S
Nature 2024 Aug;632(8023):174-181. Epub 2024 Jul 10 doi: 10.1038/s41586-024-07667-8. PMID: 38987594Free PMC Article
Ruxolitinib is highly effective in steroid-resistant graft-versus-host disease: real-world data from a single center.
Spałek A, Wieczorkiewicz-Kabut A, Zielińska P, Kopińska A, Helbig G
Pol Arch Intern Med 2023 Mar 29;133(3) Epub 2023 Feb 17 doi: 10.20452/pamw.16435. PMID: 36800797
Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study).
Johnson MI, Paley CA, Jones G, Mulvey MR, Wittkopf PG
BMJ Open 2022 Feb 10;12(2):e051073. doi: 10.1136/bmjopen-2021-051073. PMID: 35144946Free PMC Article
Clinical Application and Potential of Fecal Microbiota Transplantation.
Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ
Annu Rev Med 2019 Jan 27;70:335-351. Epub 2018 Nov 7 doi: 10.1146/annurev-med-111717-122956. PMID: 30403550
Ruxolitinib.
Ajayi S, Becker H, Reinhardt H, Engelhardt M, Zeiser R, von Bubnoff N, Wäsch R
Recent Results Cancer Res 2018;212:119-132. doi: 10.1007/978-3-319-91439-8_6. PMID: 30069628

Diagnosis

Hepatic graft-versus-host disease: what we know, when to biopsy, and how to diagnose.
Stueck AE, Fiel MI
Hum Pathol 2023 Nov;141:170-182. Epub 2023 Aug 2 doi: 10.1016/j.humpath.2023.07.007. PMID: 37541449
Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study).
Johnson MI, Paley CA, Jones G, Mulvey MR, Wittkopf PG
BMJ Open 2022 Feb 10;12(2):e051073. doi: 10.1136/bmjopen-2021-051073. PMID: 35144946Free PMC Article
Clinical Application and Potential of Fecal Microbiota Transplantation.
Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ
Annu Rev Med 2019 Jan 27;70:335-351. Epub 2018 Nov 7 doi: 10.1146/annurev-med-111717-122956. PMID: 30403550
Multiple myeloma.
Anderson KC, Shaughnessy JD Jr, Barlogie B, Harousseau JL, Roodman GD
Hematology Am Soc Hematol Educ Program 2002:214-40. doi: 10.1182/asheducation-2002.1.214. PMID: 12446425
Penicillin-resistant Streptococcus pneumoniae septic shock and meningitis complicating chronic graft versus host disease: a case report and review of the literature.
Haddad PA, Repka TL, Weisdorf DJ
Am J Med 2002 Aug 1;113(2):152-5. doi: 10.1016/s0002-9343(02)01154-3. PMID: 12133754

Therapy

An enterococcal phage-derived enzyme suppresses graft-versus-host disease.
Fujimoto K, Hayashi T, Yamamoto M, Sato N, Shimohigoshi M, Miyaoka D, Yokota C, Watanabe M, Hisaki Y, Kamei Y, Yokoyama Y, Yabuno T, Hirose A, Nakamae M, Nakamae H, Uematsu M, Sato S, Yamaguchi K, Furukawa Y, Akeda Y, Hino M, Imoto S, Uematsu S
Nature 2024 Aug;632(8023):174-181. Epub 2024 Jul 10 doi: 10.1038/s41586-024-07667-8. PMID: 38987594Free PMC Article
Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study.
Hu Y, Zhou Y, Zhang M, Zhao H, Wei G, Ge W, Cui Q, Mu Q, Chen G, Han L, Guo T, Cui J, Jiang X, Zheng X, Yu S, Li X, Zhang X, Chen M, Li X, Gao M, Wang K, Zu C, Zhang H, He X, Wang Y, Wang D, Ren J, Huang H
Cell Res 2022 Nov;32(11):995-1007. Epub 2022 Sep 23 doi: 10.1038/s41422-022-00721-y. PMID: 36151216Free PMC Article
Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
Norona J, Apostolova P, Schmidt D, Ihlemann R, Reischmann N, Taylor G, Köhler N, de Heer J, Heeg S, Andrieux G, Siranosian BA, Schmitt-Graeff A, Pfeifer D, Catalano A, Frew IJ, Proietti M, Grimbacher B, Bulashevska A, Bhatt AS, Brummer T, Clauditz T, Zabelina T, Kroeger N, Blazar BR, Boerries M, Ayuk F, Zeiser R
Blood 2020 Sep 17;136(12):1442-1455. doi: 10.1182/blood.2020005957. PMID: 32542357Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Prognosis

Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas.
Sworder BJ, Kurtz DM, Alig SK, Frank MJ, Shukla N, Garofalo A, Macaulay CW, Shahrokh Esfahani M, Olsen MN, Hamilton J, Hosoya H, Hamilton M, Spiegel JY, Baird JH, Sugio T, Carleton M, Craig AFM, Younes SF, Sahaf B, Sheybani ND, Schroers-Martin JG, Liu CL, Oak JS, Jin MC, Beygi S, Hüttmann A, Hanoun C, Dührsen U, Westin JR, Khodadoust MS, Natkunam Y, Majzner RG, Mackall CL, Diehn M, Miklos DB, Alizadeh AA
Cancer Cell 2023 Jan 9;41(1):210-225.e5. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.005. PMID: 36584673Free PMC Article
Steroid-refractory chronic graft-versus-host disease: treatment options and patient management.
Wolff D, Fatobene G, Rocha V, Kröger N, Flowers ME
Bone Marrow Transplant 2021 Sep;56(9):2079-2087. Epub 2021 Jul 3 doi: 10.1038/s41409-021-01389-5. PMID: 34218265Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease.
Santos E Sousa P, Bennett CL, Chakraverty R
Front Immunol 2018;9:963. Epub 2018 May 2 doi: 10.3389/fimmu.2018.00963. PMID: 29770141Free PMC Article
Multiple myeloma.
Anderson KC, Shaughnessy JD Jr, Barlogie B, Harousseau JL, Roodman GD
Hematology Am Soc Hematol Educ Program 2002:214-40. doi: 10.1182/asheducation-2002.1.214. PMID: 12446425

Clinical prediction guides

Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas.
Sworder BJ, Kurtz DM, Alig SK, Frank MJ, Shukla N, Garofalo A, Macaulay CW, Shahrokh Esfahani M, Olsen MN, Hamilton J, Hosoya H, Hamilton M, Spiegel JY, Baird JH, Sugio T, Carleton M, Craig AFM, Younes SF, Sahaf B, Sheybani ND, Schroers-Martin JG, Liu CL, Oak JS, Jin MC, Beygi S, Hüttmann A, Hanoun C, Dührsen U, Westin JR, Khodadoust MS, Natkunam Y, Majzner RG, Mackall CL, Diehn M, Miklos DB, Alizadeh AA
Cancer Cell 2023 Jan 9;41(1):210-225.e5. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.005. PMID: 36584673Free PMC Article
JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R
Mol Cancer Ther 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. PMID: 36252553Free PMC Article
Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study.
Hu Y, Zhou Y, Zhang M, Zhao H, Wei G, Ge W, Cui Q, Mu Q, Chen G, Han L, Guo T, Cui J, Jiang X, Zheng X, Yu S, Li X, Zhang X, Chen M, Li X, Gao M, Wang K, Zu C, Zhang H, He X, Wang Y, Wang D, Ren J, Huang H
Cell Res 2022 Nov;32(11):995-1007. Epub 2022 Sep 23 doi: 10.1038/s41422-022-00721-y. PMID: 36151216Free PMC Article
Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities.
Vasic D, Lee JB, Leung Y, Khatri I, Na Y, Abate-Daga D, Zhang L
Sci Immunol 2022 Apr 22;7(70):eabl3642. doi: 10.1126/sciimmunol.abl3642. PMID: 35452255
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article

Recent systematic reviews

Occupation and SARS-CoV-2 seroprevalence studies: a systematic review.
Boucher E, Cao C, D'Mello S, Duarte N, Donnici C, Duarte N, Bennett G; SeroTracker Consortium, Adisesh A, Arora R, Kodama D, Bobrovitz N
BMJ Open 2023 Feb 28;13(2):e063771. doi: 10.1136/bmjopen-2022-063771. PMID: 36854599Free PMC Article
Safety and efficacy of fecal microbiota transplantation in the treatment of graft-versus-host disease.
Qiao X, Biliński J, Wang L, Yang T, Luo R, Fu Y, Yang G
Bone Marrow Transplant 2023 Jan;58(1):10-19. Epub 2022 Sep 27 doi: 10.1038/s41409-022-01824-1. PMID: 36167905
Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study).
Johnson MI, Paley CA, Jones G, Mulvey MR, Wittkopf PG
BMJ Open 2022 Feb 10;12(2):e051073. doi: 10.1136/bmjopen-2021-051073. PMID: 35144946Free PMC Article
Meta-Analysis of Interleukin-2 Receptor Antagonists as the Treatment for Steroid-Refractory Acute Graft-Versus-Host Disease.
Shen MZ, Li JX, Zhang XH, Xu LP, Wang Y, Liu KY, Huang XJ, Hong SD, Mo XD
Front Immunol 2021;12:749266. Epub 2021 Sep 21 doi: 10.3389/fimmu.2021.749266. PMID: 34621279Free PMC Article
Allogeneic Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T-cell Lymphoma.
Peng YY, Xiong YY, Zhang LX, Wang J, Zhang HB, Xiao Q, Guo SL
Turk J Haematol 2021 Jun 1;38(2):126-137. Epub 2021 Feb 4 doi: 10.4274/tjh.galenos.2021.2020.0438. PMID: 33535731Free PMC Article

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