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Colon serrated polyposis

MedGen UID:
474430
•Concept ID:
C3272797
•
Disease or Syndrome
Synonyms: Colon Serrated Polyposis; colon serrated polyposis
 
Monarch Initiative: MONDO:0100290

Definition

The presence of multiple serrated polyps in the colon. The polyps are predominantly sessile serrated adenomas/polyps. A minority of the polyps are microvesicular variants of hyperplastic polyps. According to some authors, the polyps are proximal to the sigmoid colon. According to others, the polyps are distributed throughout the entire colon. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon serrated polyposis

Professional guidelines

PubMed

Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Etiology

Update on genetic predisposition to colorectal cancer and polyposis.
Valle L, de Voer RM, Goldberg Y, Sjursen W, Försti A, Ruiz-Ponte C, Caldés T, Garré P, Olsen MF, Nordling M, Castellvi-Bel S, Hemminki K
Mol Aspects Med 2019 Oct;69:10-26. Epub 2019 Mar 18 doi: 10.1016/j.mam.2019.03.001. PMID: 30862463
Pathology and genetics of hereditary colorectal cancer.
Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA
Pathology 2018 Jan;50(1):49-59. Epub 2017 Nov 21 doi: 10.1016/j.pathol.2017.09.004. PMID: 29169633
Epidemiology and risk factors of colorectal polyps.
Øines M, Helsingen LM, Bretthauer M, Emilsson L
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):419-424. Epub 2017 Jun 28 doi: 10.1016/j.bpg.2017.06.004. PMID: 28842051
Hereditary Colorectal Cancer Syndromes.
Wells K, Wise PE
Surg Clin North Am 2017 Jun;97(3):605-625. doi: 10.1016/j.suc.2017.01.009. PMID: 28501250
Pathology of early lower GI cancer.
Geboes K, Ectors N, Geboes KP
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):963-78. doi: 10.1016/j.bpg.2005.04.005. PMID: 16338652

Diagnosis

Serrated polyposis syndrome; epidemiology and management.
Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Hereditary Colorectal Cancer.
Hampel H, Kalady MF, Pearlman R, Stanich PP
Hematol Oncol Clin North Am 2022 Jun;36(3):429-447. Epub 2022 May 13 doi: 10.1016/j.hoc.2022.02.002. PMID: 35577708
The histomorphological and molecular landscape of colorectal adenomas and serrated lesions.
Galuppini F, Fassan M, Mastracci L, Gafà R, Lo Mele M, Lazzi S, Remo A, Parente P, D'Amuri A, Mescoli C, Tatangelo F, Lanza G
Pathologica 2021 Jun;113(3):218-229. doi: 10.32074/1591-951X-270. PMID: 34294939Free PMC Article
The third pathway of colorectal carcinogenesis.
Rubio CA, Puppa G, de Petris G, Kis L, Schmidt PT
J Clin Pathol 2018 Jan;71(1):7-11. Epub 2017 Jul 27 doi: 10.1136/jclinpath-2017-204660. PMID: 28751521
Pathology of early lower GI cancer.
Geboes K, Ectors N, Geboes KP
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):963-78. doi: 10.1016/j.bpg.2005.04.005. PMID: 16338652

Therapy

Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.
Nakaoka M, Chiba H, Kobayashi M, Okada N, Arimoto J, Tachikawa J, Ashikari K, Kuwabara H
Dig Dis 2024;42(1):31-40. Epub 2023 Nov 15 doi: 10.1159/000534968. PMID: 37967542Free PMC Article
Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Risk of Colorectal Cancer in Serrated Polyposis Syndrome: A Systematic Review and Meta-analysis.
Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849
Sessile Serrated Polyposis: Not an Inherited Syndrome?
Cauley CE, Hassab TH, Feinberg A, Church J
Dis Colon Rectum 2020 Feb;63(2):183-189. doi: 10.1097/DCR.0000000000001537. PMID: 31914111
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article

Prognosis

Serrated polyposis syndrome: defining the epidemiology and predicting the risk of dysplasia.
Dierick NR, Nicholson BD, Fanshawe TR, Sundaralingam P, Kostalas SN
BMC Gastroenterol 2024 May 16;24(1):167. doi: 10.1186/s12876-024-03247-2. PMID: 38755550Free PMC Article
Risk of Colorectal Cancer in Serrated Polyposis Syndrome: A Systematic Review and Meta-analysis.
Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY
Gut 2020 Dec;69(12):2165-2179. Epub 2020 Mar 26 doi: 10.1136/gutjnl-2019-320019. PMID: 32217638
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Pathology of early lower GI cancer.
Geboes K, Ectors N, Geboes KP
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):963-78. doi: 10.1016/j.bpg.2005.04.005. PMID: 16338652

Clinical prediction guides

Serrated polyposis syndrome: defining the epidemiology and predicting the risk of dysplasia.
Dierick NR, Nicholson BD, Fanshawe TR, Sundaralingam P, Kostalas SN
BMC Gastroenterol 2024 May 16;24(1):167. doi: 10.1186/s12876-024-03247-2. PMID: 38755550Free PMC Article
Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY
Gut 2020 Dec;69(12):2165-2179. Epub 2020 Mar 26 doi: 10.1136/gutjnl-2019-320019. PMID: 32217638
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Pathology of early lower GI cancer.
Geboes K, Ectors N, Geboes KP
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):963-78. doi: 10.1016/j.bpg.2005.04.005. PMID: 16338652

Recent systematic reviews

Risk of Colorectal Cancer in Serrated Polyposis Syndrome: A Systematic Review and Meta-analysis.
Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849

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