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Adenoma, cortisol-producing

MedGen UID:
462503
•Concept ID:
C3151153
•
Finding
Synonym: ADENOMA, CORTISOL-PRODUCING
 
OMIM®: 613815

Professional guidelines

PubMed

Usefulness of 68 Ga-Pentixafor PET/CT on Diagnosis and Management of Cushing Syndrome.
Ding J, Tong A, Hacker M, Feng M, Huo L, Li X
Clin Nucl Med 2022 Aug 1;47(8):669-676. Epub 2022 Apr 22 doi: 10.1097/RLU.0000000000004244. PMID: 35452014
The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA).
Motomura N, Yamazaki Y, Koga D, Harashima S, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Kwon GE, Choi MH, Ito A, Sasano H
Int J Mol Sci 2022 Feb 16;23(4) doi: 10.3390/ijms23042174. PMID: 35216289Free PMC Article
Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Baba R, Oki K, Gomez-Sanchez CE, Otagaki Y, Itcho K, Kobuke K, Kodama T, Nagano G, Ohno H, Yoneda M, Hattori N
Mol Cell Endocrinol 2021 Dec 1;538:111456. Epub 2021 Sep 11 doi: 10.1016/j.mce.2021.111456. PMID: 34520814Free PMC Article

Recent clinical studies

Etiology

Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics.
Watanabe D, Morimoto S, Morishima N, Ichihara A
Heart Vessels 2024 Jan;39(1):65-74. Epub 2023 Sep 11 doi: 10.1007/s00380-023-02309-x. PMID: 37695542
Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism.
Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y
EBioMedicine 2023 Sep;95:104733. Epub 2023 Aug 3 doi: 10.1016/j.ebiom.2023.104733. PMID: 37543511Free PMC Article
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.
Dalmazi GD, Beuschlein F
Horm Metab Res 2017 Apr;49(4):301-306. Epub 2016 Nov 21 doi: 10.1055/s-0042-120416. PMID: 27871112
cAMP signaling in cortisol-producing adrenal adenoma.
Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Eur J Endocrinol 2015 Oct;173(4):M99-106. Epub 2015 Jul 2 doi: 10.1530/EJE-15-0353. PMID: 26139209
Image-guided ablation of adrenal tumors.
Ethier MD, Beland MD, Mayo-Smith W
Tech Vasc Interv Radiol 2013 Dec;16(4):262-8. doi: 10.1053/j.tvir.2013.08.008. PMID: 24238381

Diagnosis

Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism.
Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y
EBioMedicine 2023 Sep;95:104733. Epub 2023 Aug 3 doi: 10.1016/j.ebiom.2023.104733. PMID: 37543511Free PMC Article
Targeted Mutational Analysis of Cortisol-Producing Adenomas.
Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K
J Clin Endocrinol Metab 2022 Jan 18;107(2):e594-e603. doi: 10.1210/clinem/dgab682. PMID: 34534321Free PMC Article
Genetics of adrenocortical tumours.
Åkerström T, Carling T, Beuschlein F, Hellman P
J Intern Med 2016 Dec;280(6):540-550. doi: 10.1111/joim.12452. PMID: 27864864
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203
Image-guided ablation of adrenal tumors.
Ethier MD, Beland MD, Mayo-Smith W
Tech Vasc Interv Radiol 2013 Dec;16(4):262-8. doi: 10.1053/j.tvir.2013.08.008. PMID: 24238381

Therapy

Adrenalectomy for Cushing's syndrome: do's and don'ts.
Paduraru DN, Nica A, Carsote M, Valea A
J Med Life 2016 Oct-Dec;9(4):334-341. PMID: 27928434Free PMC Article
Systemic therapy of Cushing's syndrome.
Eckstein N, Haas B, Hass MD, Pfeifer V
Orphanet J Rare Dis 2014 Aug 5;9:122. doi: 10.1186/s13023-014-0122-8. PMID: 25091295Free PMC Article
Image-guided ablation of adrenal tumors.
Ethier MD, Beland MD, Mayo-Smith W
Tech Vasc Interv Radiol 2013 Dec;16(4):262-8. doi: 10.1053/j.tvir.2013.08.008. PMID: 24238381
Classic and recent etiologies of Cushing's syndrome: diagnosis and therapy.
Beauregard C, Dickstein G, Lacroix A
Treat Endocrinol 2002;1(2):79-94. doi: 10.2165/00024677-200201020-00002. PMID: 15765624
Somatostatin analogs in ectopic corticotropin production.
von Werder K, Muller OA, Stalla GK
Metabolism 1996 Aug;45(8 Suppl 1):129-31. doi: 10.1016/s0026-0495(96)90107-9. PMID: 8769407

Prognosis

Characterization of Adrenal miRNA-Based Dysregulations in Cushing's Syndrome.
Vetrivel S, Zhang R, Engel M, Oßwald A, Watts D, Chen A, Wielockx B, Sbiera S, Reincke M, Riester A
Int J Mol Sci 2022 Jul 12;23(14) doi: 10.3390/ijms23147676. PMID: 35887024Free PMC Article
Genomic insights into Cushing syndrome.
Assié G
Ann Endocrinol (Paris) 2018 Jun;79(3):119-122. Epub 2018 May 4 doi: 10.1016/j.ando.2018.03.011. PMID: 29735160
Genetics of adrenocortical tumours.
Åkerström T, Carling T, Beuschlein F, Hellman P
J Intern Med 2016 Dec;280(6):540-550. doi: 10.1111/joim.12452. PMID: 27864864
Image-guided ablation of adrenal tumors.
Ethier MD, Beland MD, Mayo-Smith W
Tech Vasc Interv Radiol 2013 Dec;16(4):262-8. doi: 10.1053/j.tvir.2013.08.008. PMID: 24238381
Adrenocorticotropic hormone-independent Cushing's syndrome.
Bourdeau I, Lampron A, Costa MH, Tadjine M, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2007 Jun;14(3):219-25. doi: 10.1097/MED.0b013e32814db842. PMID: 17940443

Clinical prediction guides

Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism.
Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y
EBioMedicine 2023 Sep;95:104733. Epub 2023 Aug 3 doi: 10.1016/j.ebiom.2023.104733. PMID: 37543511Free PMC Article
Targeted Mutational Analysis of Cortisol-Producing Adenomas.
Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K
J Clin Endocrinol Metab 2022 Jan 18;107(2):e594-e603. doi: 10.1210/clinem/dgab682. PMID: 34534321Free PMC Article
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203
Clinicopathological correlates of adrenal Cushing's syndrome.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Mar;68(3):175-86. Epub 2014 Nov 25 doi: 10.1136/jclinpath-2014-202612. PMID: 25425660
Image-guided ablation of adrenal tumors.
Ethier MD, Beland MD, Mayo-Smith W
Tech Vasc Interv Radiol 2013 Dec;16(4):262-8. doi: 10.1053/j.tvir.2013.08.008. PMID: 24238381

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