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Early repolarization associated with ventricular fibrillation

MedGen UID:
462202
Concept ID:
C3150852
Disease or Syndrome
Synonyms: EARLY REPOLARIZATION ASSOCIATED WITH VENTRICULAR FIBRILLATION; EARLY REPOLARIZATION SYNDROME
 
Monarch Initiative: MONDO:0013318
OMIM®: 613601

Definition

Electrocardiographic (ECG) early repolarization, defined as an elevation of the QRS-ST junction (J-point) of at least 1.0 mm (0.1 mV) from baseline in the inferior or lateral lead, manifest as QRS slurring or notching, is a common ECG finding that is generally considered to be benign but may be associated with ventricular fibrillation in some patients (summary by Haissaguerre et al., 2008). [from OMIM]

Professional guidelines

PubMed

Kowlgi GN, Cha YM
Europace 2020 Dec 23;22(12):1768-1780. doi: 10.1093/europace/euaa232. PMID: 32984880
Patton KK, Ellinor PT, Ezekowitz M, Kowey P, Lubitz SA, Perez M, Piccini J, Turakhia M, Wang P, Viskin S; American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology and Council on Functional Genomics and Translational Biology
Circulation 2016 Apr 12;133(15):1520-9. Epub 2016 Mar 7 doi: 10.1161/CIR.0000000000000388. PMID: 27067089
Lévy S, Sbragia P
J Interv Card Electrophysiol 2011 Dec;32(3):181-6. Epub 2011 Jul 21 doi: 10.1007/s10840-011-9597-6. PMID: 21833514

Recent clinical studies

Etiology

Morita H, Asada S, Ueoka A, Mizuno T, Masuda T, Miyamoto M, Kawada S, Nakagawa K, Nishii N, Yuasa S
Heart Rhythm 2024 Oct;21(10):1787-1794. Epub 2024 May 6 doi: 10.1016/j.hrthm.2024.04.101. PMID: 38710349
Nademanee K, Haissaguerre M, Hocini M, Nogami A, Cheniti G, Duchateau J, Behr ER, Saba M, Bokan R, Lou Q, Amnueypol M, Coronel R, Khongphatthanayothin A, Veerakul G
Circulation 2019 Oct 29;140(18):1477-1490. Epub 2019 Sep 23 doi: 10.1161/CIRCULATIONAHA.118.039022. PMID: 31542949
Patton KK, Ellinor PT, Ezekowitz M, Kowey P, Lubitz SA, Perez M, Piccini J, Turakhia M, Wang P, Viskin S; American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology and Council on Functional Genomics and Translational Biology
Circulation 2016 Apr 12;133(15):1520-9. Epub 2016 Mar 7 doi: 10.1161/CIR.0000000000000388. PMID: 27067089
Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD
Circulation 2013 Apr 16;127(15):1620-9. doi: 10.1161/CIRCULATIONAHA.112.143149. PMID: 23588960
Antzelevitch C, Yan GX
Heart Rhythm 2010 Apr;7(4):549-58. Epub 2009 Dec 11 doi: 10.1016/j.hrthm.2009.12.006. PMID: 20153265Free PMC Article

Diagnosis

Morita H, Asada S, Ueoka A, Mizuno T, Masuda T, Miyamoto M, Kawada S, Nakagawa K, Nishii N, Yuasa S
Heart Rhythm 2024 Oct;21(10):1787-1794. Epub 2024 May 6 doi: 10.1016/j.hrthm.2024.04.101. PMID: 38710349
Nogami A, Komatsu Y, Talib AK, Phanthawimol W, Naeemah QJ, Haruna T, Morishima I
JACC Clin Electrophysiol 2023 Oct;9(10):2172-2196. Epub 2023 Jul 26 doi: 10.1016/j.jacep.2023.05.040. PMID: 37498247
Buttà C, Zappia L, Laterra G, Roberto M
Ann Noninvasive Electrocardiol 2020 May;25(3) Epub 2019 Nov 28 doi: 10.1111/anec.12726. PMID: 31778001Free PMC Article
Ghosh S, Cooper DH, Vijayakumar R, Zhang J, Pollak S, Haïssaguerre M, Rudy Y
Heart Rhythm 2010 Apr;7(4):534-7. Epub 2009 Dec 11 doi: 10.1016/j.hrthm.2009.12.005. PMID: 20153422Free PMC Article
Antzelevitch C, Yan GX
Heart Rhythm 2010 Apr;7(4):549-58. Epub 2009 Dec 11 doi: 10.1016/j.hrthm.2009.12.006. PMID: 20153265Free PMC Article

Therapy

Moey MYY, Wilkin M, Gandjbakhch E, Bachelot A, Abbar B, Pinna B, Simon JM, Funck-Brentano C, Salem JE
Therapie 2022 May-Jun;77(3):265-271. Epub 2021 Oct 24 doi: 10.1016/j.therap.2021.10.008. PMID: 34895755
Adler A, Gollob MH
Curr Opin Cardiol 2015 Jan;30(1):8-16. doi: 10.1097/HCO.0000000000000126. PMID: 25389652
Yagishita A, Yamauchi Y, Obayashi T, Hirao K
J Interv Card Electrophysiol 2014 Nov;41(2):145-6. Epub 2014 Sep 17 doi: 10.1007/s10840-014-9933-8. PMID: 25227864
Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD
Circulation 2013 Apr 16;127(15):1620-9. doi: 10.1161/CIRCULATIONAHA.112.143149. PMID: 23588960
Iguchi K, Noda T, Kamakura S, Shimizu W
Heart Rhythm 2013 Apr;10(4):604-6. Epub 2012 Nov 9 doi: 10.1016/j.hrthm.2012.11.001. PMID: 23142636

Prognosis

Morita H, Asada S, Ueoka A, Mizuno T, Masuda T, Miyamoto M, Kawada S, Nakagawa K, Nishii N, Yuasa S
Heart Rhythm 2024 Oct;21(10):1787-1794. Epub 2024 May 6 doi: 10.1016/j.hrthm.2024.04.101. PMID: 38710349
Kamakura T, Gourraud JB, Clementy N, Maury P, Mansourati J, Klug D, Da Costa A, Pasquie JL, Mabo P, Chavernac P, Laurent G, Defaye P, Laborderie J, Leenhardt A, Sadoul N, Deharo JC, Giraudeau C, Quentin A, Jesel L, Thollet A, Tixier R, Derval N, Haissaguerre M, Probst V, Sacher F
Heart Rhythm 2022 Aug;19(8):1306-1314. Epub 2022 Apr 5 doi: 10.1016/j.hrthm.2022.03.1233. PMID: 35395407
Buttà C, Zappia L, Laterra G, Roberto M
Ann Noninvasive Electrocardiol 2020 May;25(3) Epub 2019 Nov 28 doi: 10.1111/anec.12726. PMID: 31778001Free PMC Article
Patton KK, Ellinor PT, Ezekowitz M, Kowey P, Lubitz SA, Perez M, Piccini J, Turakhia M, Wang P, Viskin S; American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology and Council on Functional Genomics and Translational Biology
Circulation 2016 Apr 12;133(15):1520-9. Epub 2016 Mar 7 doi: 10.1161/CIR.0000000000000388. PMID: 27067089
Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD
Circulation 2013 Apr 16;127(15):1620-9. doi: 10.1161/CIRCULATIONAHA.112.143149. PMID: 23588960

Clinical prediction guides

Morita H, Asada S, Ueoka A, Mizuno T, Masuda T, Miyamoto M, Kawada S, Nakagawa K, Nishii N, Yuasa S
Heart Rhythm 2024 Oct;21(10):1787-1794. Epub 2024 May 6 doi: 10.1016/j.hrthm.2024.04.101. PMID: 38710349
Morita H, Ueoka A, Mizuno T, Masuda T, Asada S, Ejiri K, Miyamoto M, Kawada S, Nakagawa K, Nishii N, Yuasa S
Heart Rhythm 2024 May;21(5):562-570. Epub 2024 Jan 17 doi: 10.1016/j.hrthm.2024.01.016. PMID: 38242221
Kamakura T, Gourraud JB, Clementy N, Maury P, Mansourati J, Klug D, Da Costa A, Pasquie JL, Mabo P, Chavernac P, Laurent G, Defaye P, Laborderie J, Leenhardt A, Sadoul N, Deharo JC, Giraudeau C, Quentin A, Jesel L, Thollet A, Tixier R, Derval N, Haissaguerre M, Probst V, Sacher F
Heart Rhythm 2022 Aug;19(8):1306-1314. Epub 2022 Apr 5 doi: 10.1016/j.hrthm.2022.03.1233. PMID: 35395407
Wang G, Zhao N, Zhong S, Wang H
Clin Cardiol 2022 May;45(5):461-473. Epub 2022 Mar 7 doi: 10.1002/clc.23804. PMID: 35253242Free PMC Article
Rezus C, Floria M, Moga VD, Sirbu O, Dima N, Ionescu SD, Ambarus V
Ann Noninvasive Electrocardiol 2014 Jan;19(1):15-22. Epub 2013 Sep 30 doi: 10.1111/anec.12113. PMID: 24118137Free PMC Article

Recent systematic reviews

Wang G, Zhao N, Zhong S, Wang H
Clin Cardiol 2022 May;45(5):461-473. Epub 2022 Mar 7 doi: 10.1002/clc.23804. PMID: 35253242Free PMC Article
Xu S, Yang L, Hong D, Chen L, Wang X
Cardiology 2019;144(3-4):69-75. Epub 2019 Aug 21 doi: 10.1159/000501474. PMID: 31434097

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