U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Leukemia, acute lymphocytic, susceptibility to, 2(ALL2)

MedGen UID:
442766
•Concept ID:
C2751593
•
Neoplastic Process
Synonyms: Leukemia, acute lymphoblastic 2; LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 2
 
Monarch Initiative: MONDO:0013109
OMIM®: 613067

Professional guidelines

PubMed

Interleukin-8 Rs4073 Genotypes as Prognostic Predictors for Childhood Acute Lymphocytic Leukemia.
Hsu PC, Chen CC, Yang YC, Shih HY, Chin YT, Pei JS, Chang WS, Tsai CW, Kuo CC, Bau DT
Anticancer Res 2023 Dec;43(12):5359-5366. doi: 10.21873/anticanres.16739. PMID: 38030180
TP53, ETV6 and RUNX1 germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia.
Junk SV, Klein N, Schreek S, Zimmermann M, Möricke A, Bleckmann K, Alten J, Dagdan E, Cario G, Kratz CP, Schrappe M, Stanulla M
Haematologica 2019 Sep;104(9):e402-e405. Epub 2019 Jul 9 doi: 10.3324/haematol.2018.205849. PMID: 31289210Free PMC Article
Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese.
Urayama KY, Takagi M, Kawaguchi T, Matsuo K, Tanaka Y, Ayukawa Y, Arakawa Y, Hasegawa D, Yuza Y, Kaneko T, Noguchi Y, Taneyama Y, Ota S, Inukai T, Yanagimachi M, Keino D, Koike K, Toyama D, Nakazawa Y, Kurosawa H, Nakamura K, Moriwaki K, Goto H, Sekinaka Y, Morita D, Kato M, Takita J, Tanaka T, Inazawa J, Koh K, Ishida Y, Ohara A, Mizutani S, Matsuda F, Manabe A
Sci Rep 2018 Jan 15;8(1):789. doi: 10.1038/s41598-017-19127-7. PMID: 29335448Free PMC Article

Recent clinical studies

Etiology

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
Am J Hum Genet 2021 Oct 7;108(10):1823-1835. Epub 2021 Aug 31 doi: 10.1016/j.ajhg.2021.08.004. PMID: 34469753Free PMC Article
MLL-Rearranged Acute Lymphoblastic Leukemia.
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
BCR-ABL (Ph)-like acute leukemia-Pathogenesis, diagnosis and therapeutic options.
Ofran Y, Izraeli S
Blood Rev 2017 Mar;31(2):11-16. Epub 2016 Sep 16 doi: 10.1016/j.blre.2016.09.001. PMID: 27665024
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article
Inherited susceptibility to pediatric acute lymphoblastic leukemia.
Levine RL
Nat Genet 2009 Sep;41(9):957-8. doi: 10.1038/ng0909-957. PMID: 19710713

Diagnosis

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia.
Del Gaizo M, Sergio I, Lazzari S, Cialfi S, Pelullo M, Screpanti I, Felli MP
Int J Mol Sci 2022 Jan 13;23(2) doi: 10.3390/ijms23020829. PMID: 35055013Free PMC Article
Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis.
Ono R, Ashiarai M, Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A, Hasegawa D
Int J Hematol 2021 Feb;113(2):297-301. Epub 2020 Sep 26 doi: 10.1007/s12185-020-02999-3. PMID: 32979171
MLL-Rearranged Acute Lymphoblastic Leukemia.
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Prospects for Venetoclax in Myelodysplastic Syndromes.
Garcia JS
Hematol Oncol Clin North Am 2020 Apr;34(2):441-448. Epub 2019 Dec 11 doi: 10.1016/j.hoc.2019.10.005. PMID: 32089221
BCR-ABL (Ph)-like acute leukemia-Pathogenesis, diagnosis and therapeutic options.
Ofran Y, Izraeli S
Blood Rev 2017 Mar;31(2):11-16. Epub 2016 Sep 16 doi: 10.1016/j.blre.2016.09.001. PMID: 27665024

Therapy

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
Am J Hum Genet 2021 Oct 7;108(10):1823-1835. Epub 2021 Aug 31 doi: 10.1016/j.ajhg.2021.08.004. PMID: 34469753Free PMC Article
Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis.
Ono R, Ashiarai M, Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A, Hasegawa D
Int J Hematol 2021 Feb;113(2):297-301. Epub 2020 Sep 26 doi: 10.1007/s12185-020-02999-3. PMID: 32979171
MLL-Rearranged Acute Lymphoblastic Leukemia.
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Prospects for Venetoclax in Myelodysplastic Syndromes.
Garcia JS
Hematol Oncol Clin North Am 2020 Apr;34(2):441-448. Epub 2019 Dec 11 doi: 10.1016/j.hoc.2019.10.005. PMID: 32089221
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Prognosis

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
Am J Hum Genet 2021 Oct 7;108(10):1823-1835. Epub 2021 Aug 31 doi: 10.1016/j.ajhg.2021.08.004. PMID: 34469753Free PMC Article
MLL-Rearranged Acute Lymphoblastic Leukemia.
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia.
Järviaho T, Zachariadis V, Tesi B, Chiang S, Bryceson YT, Möttönen M, Niinimäki R, Bang B, Rahikkala E, Taylan F, Uusimaa J, Harila-Saari A, Nordgren A
Br J Haematol 2019 Apr;185(2):354-357. Epub 2018 Jul 13 doi: 10.1111/bjh.15494. PMID: 30004112
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Clinical prediction guides

Genetic susceptibility and late bone outcomes in childhood acute lymphoblastic leukemia survivors.
Geneviève N, Mojgan Y, Nahid Y, Vincenzo F, Simon G, Daniel S, Maja K, Nathalie A, Despoina M
J Bone Miner Res 2024 Mar 22;39(2):130-138. doi: 10.1093/jbmr/zjad013. PMID: 38477791
Telomere length and cancer risk: finding Goldilocks.
Savage SA
Biogerontology 2024 Apr;25(2):265-278. Epub 2023 Dec 18 doi: 10.1007/s10522-023-10080-9. PMID: 38109000
Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
Am J Hum Genet 2021 Oct 7;108(10):1823-1835. Epub 2021 Aug 31 doi: 10.1016/j.ajhg.2021.08.004. PMID: 34469753Free PMC Article
Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis.
Ono R, Ashiarai M, Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A, Hasegawa D
Int J Hematol 2021 Feb;113(2):297-301. Epub 2020 Sep 26 doi: 10.1007/s12185-020-02999-3. PMID: 32979171
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030

Recent systematic reviews

Relationship between NAT2 polymorphisms and onset risk of acute leukemia: a systematic review and meta-analysis.
Jiang WH, Wang XT, Zheng LD, Yan QQ, Chen LL
Eur Rev Med Pharmacol Sci 2019 Nov;23(21):9259-9266. doi: 10.26355/eurrev_201911_19418. PMID: 31773677
Meat, fish, dairy products and risk of hematological malignancies in adults - a systematic review and meta-analysis of prospective studies.
Sergentanis TN, Ntanasis-Stathopoulos I, Tzanninis IG, Gavriatopoulou M, Sergentanis IN, Dimopoulos MA, Psaltopoulou T
Leuk Lymphoma 2019 Aug;60(8):1978-1990. Epub 2019 Mar 26 doi: 10.1080/10428194.2018.1563693. PMID: 30912696
Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis.
Kelly MJ, Trikalinos TA, Dahabreh IJ, Gianferante M, Parsons SK
Am J Hematol 2014 Oct;89(10):992-7. Epub 2014 Jul 22 doi: 10.1002/ajh.23784. PMID: 24912665Free PMC Article
The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis.
Liu D, Wu D, Li H, Dong M
Gene 2014 Apr 1;538(2):209-16. Epub 2014 Jan 28 doi: 10.1016/j.gene.2014.01.049. PMID: 24486506
Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis.
Vijayakrishnan J, Houlston RS
Haematologica 2010 Aug;95(8):1405-14. Epub 2010 May 29 doi: 10.3324/haematol.2010.022095. PMID: 20511665Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...