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Schizophrenia, susceptibility to

MedGen UID:
390920
Concept ID:
C2675945
Finding
Synonym: SCHIZOPHRENIA, SUSCEPTIBILITY TO
 
Monarch Initiative: MONDO:0100182
OMIM®: 116790; 126451; 182135; 605566; 607093

Definition

An inherited susceptibility or predisposition to developing schizophrenia. [from MONDO]

Professional guidelines

PubMed

Zamanpoor M
Psychiatr Genet 2020 Feb;30(1):1-9. doi: 10.1097/YPG.0000000000000245. PMID: 31764709
Legge SE, Dennison CA, Pardiñas AF, Rees E, Lynham AJ, Hopkins L, Bates L, Kirov G, Owen MJ, O'Donovan MC, Walters JTR
Br J Psychiatry 2020 May;216(5):259-266. doi: 10.1192/bjp.2019.120. PMID: 31155017
Pandey JP, Namboodiri AM, Elston RC
Hum Genet 2016 Oct;135(10):1175-9. Epub 2016 Jul 8 doi: 10.1007/s00439-016-1706-2. PMID: 27393575Free PMC Article

Recent clinical studies

Etiology

Owen MJ, Legge SE, Rees E, Walters JTR, O'Donovan MC
Mol Psychiatry 2023 Sep;28(9):3638-3647. Epub 2023 Oct 18 doi: 10.1038/s41380-023-02293-8. PMID: 37853064Free PMC Article
Punzi G, Bharadwaj R, Ursini G
Prog Mol Biol Transl Sci 2018;158:195-226. Epub 2018 Jun 11 doi: 10.1016/bs.pmbts.2018.04.010. PMID: 30072054
Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan PF, O'Donovan MC, Shi Y
Nat Genet 2017 Nov;49(11):1576-1583. Epub 2017 Oct 9 doi: 10.1038/ng.3973. PMID: 28991256
van de Leemput J, Hess JL, Glatt SJ, Tsuang MT
Adv Genet 2016;96:99-141. Epub 2016 Sep 27 doi: 10.1016/bs.adgen.2016.08.001. PMID: 27968732
Javed MA
J Pak Med Assoc 2000 Feb;50(2):63-8. PMID: 10769526

Diagnosis

Birnbaum R, Weinberger DR
Am J Psychiatry 2024 Jun 1;181(6):482-492. doi: 10.1176/appi.ajp.20240305. PMID: 38822584
Owen MJ, Legge SE, Rees E, Walters JTR, O'Donovan MC
Mol Psychiatry 2023 Sep;28(9):3638-3647. Epub 2023 Oct 18 doi: 10.1038/s41380-023-02293-8. PMID: 37853064Free PMC Article
Hung CC, Lin CH, Lane HY
Int J Mol Sci 2021 Sep 8;22(18) doi: 10.3390/ijms22189718. PMID: 34575878Free PMC Article
Hartwig FP, Borges MC, Horta BL, Bowden J, Davey Smith G
JAMA Psychiatry 2017 Dec 1;74(12):1226-1233. doi: 10.1001/jamapsychiatry.2017.3191. PMID: 29094161Free PMC Article
van Os J, Kapur S
Lancet 2009 Aug 22;374(9690):635-45. doi: 10.1016/S0140-6736(09)60995-8. PMID: 19700006

Therapy

Devanand DP, Jeste DV, Stroup TS, Goldberg TE
Int Psychogeriatr 2024 Jan;36(1):28-42. Epub 2023 Mar 3 doi: 10.1017/S1041610223000157. PMID: 36866576
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
van Os J, Kapur S
Lancet 2009 Aug 22;374(9690):635-45. doi: 10.1016/S0140-6736(09)60995-8. PMID: 19700006
Morrison PD, Murray RM
Curr Biol 2005 Dec 20;15(24):R980-4. doi: 10.1016/j.cub.2005.11.059. PMID: 16360673
Peet M
World Rev Nutr Diet 2005;95:17-28. doi: 10.1159/000088267. PMID: 16151267

Prognosis

Birnbaum R, Weinberger DR
Am J Psychiatry 2024 Jun 1;181(6):482-492. doi: 10.1176/appi.ajp.20240305. PMID: 38822584
Dennison CA, Legge SE, Pardiñas AF, Walters JTR
Schizophr Res 2020 Mar;217:4-12. Epub 2019 Nov 25 doi: 10.1016/j.schres.2019.10.048. PMID: 31780348
van Os J, Kapur S
Lancet 2009 Aug 22;374(9690):635-45. doi: 10.1016/S0140-6736(09)60995-8. PMID: 19700006
Peet M
World Rev Nutr Diet 2005;95:17-28. doi: 10.1159/000088267. PMID: 16151267
Javed MA
J Pak Med Assoc 2000 Feb;50(2):63-8. PMID: 10769526

Clinical prediction guides

Owen MJ, Legge SE, Rees E, Walters JTR, O'Donovan MC
Mol Psychiatry 2023 Sep;28(9):3638-3647. Epub 2023 Oct 18 doi: 10.1038/s41380-023-02293-8. PMID: 37853064Free PMC Article
Ni G, Zeng J, Revez JA, Wang Y, Zheng Z, Ge T, Restuadi R, Kiewa J, Nyholt DR, Coleman JRI, Smoller JW; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Yang J, Visscher PM, Wray NR
Biol Psychiatry 2021 Nov 1;90(9):611-620. Epub 2021 May 4 doi: 10.1016/j.biopsych.2021.04.018. PMID: 34304866Free PMC Article
Koutsouleris N, Dwyer DB, Degenhardt F, Maj C, Urquijo-Castro MF, Sanfelici R, Popovic D, Oeztuerk O, Haas SS, Weiske J, Ruef A, Kambeitz-Ilankovic L, Antonucci LA, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Kambeitz J, Haidl TK, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Walger P, Franscini M, Traber-Walker N, Schimmelmann BG, Flückiger R, Michel C, Rössler W, Borisov O, Krawitz PM, Heekeren K, Buechler R, Pantelis C, Falkai P, Salokangas RKR, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Theodoridou A, Meisenzahl E; PRONIA Consortium
JAMA Psychiatry 2021 Feb 1;78(2):195-209. doi: 10.1001/jamapsychiatry.2020.3604. PMID: 33263726Free PMC Article
Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan PF, O'Donovan MC, Shi Y
Nat Genet 2017 Nov;49(11):1576-1583. Epub 2017 Oct 9 doi: 10.1038/ng.3973. PMID: 28991256
Jin C, Zhou Z, Li W, Zhang F, Yuan J, Liu X, Cheng Z
Psychiatry Res 2016 Jul 30;241:104-7. Epub 2016 Apr 27 doi: 10.1016/j.psychres.2016.04.084. PMID: 27156032

Recent systematic reviews

Lancaster TM, Dimitriadis SI, Perry G, Zammit S, O'Donovan MC, Linden DE
Schizophr Bull 2022 Mar 1;48(2):524-532. doi: 10.1093/schbul/sbab125. PMID: 34662406Free PMC Article
Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G, Hahn M, Agarwal SM
Acta Psychiatr Scand 2021 Dec;144(6):524-536. Epub 2021 Sep 16 doi: 10.1111/acps.13365. PMID: 34458979
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
de Matos LP, Santana CV, Souza RP
Psychiatry Res 2015 Sep 30;229(1-2):586-8. Epub 2015 Jul 21 doi: 10.1016/j.psychres.2015.07.054. PMID: 26213377
Chen LP, Murad MH, Paras ML, Colbenson KM, Sattler AL, Goranson EN, Elamin MB, Seime RJ, Shinozaki G, Prokop LJ, Zirakzadeh A
Mayo Clin Proc 2010 Jul;85(7):618-29. Epub 2010 May 10 doi: 10.4065/mcp.2009.0583. PMID: 20458101Free PMC Article

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