U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dystonia, primary cervical

MedGen UID:
400854
•Concept ID:
C1865819
•
Disease or Syndrome
Synonyms: Cervical Dystonia, Primary; Dystonia, Primary Cervical
 
OMIM®: 602124

Professional guidelines

PubMed

Long-Term Abobotulinumtoxin A Treatment of Cervical Dystonia.
Bentivoglio AR, Di Stasio E, Mulas D, Cerbarano ML, Ialongo T, Laurienzo A, Petracca M
Neurotox Res 2017 Aug;32(2):291-300. Epub 2017 May 6 doi: 10.1007/s12640-017-9737-6. PMID: 28478527
Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A.
Tiple D, Strano S, Colosimo C, Fabbrini G, Calcagnini G, Prencipe M, Berardelli A
J Neurol 2008 Jun;255(6):843-7. Epub 2008 May 7 doi: 10.1007/s00415-008-0753-6. PMID: 18458860
Minimum incidence of primary cervical dystonia in a multiethnic health care population.
Marras C, Van den Eeden SK, Fross RD, Benedict-Albers KS, Klingman J, Leimpeter AD, Nelson LM, Risch N, Karter AJ, Bernstein AL, Tanner CM
Neurology 2007 Aug 14;69(7):676-80. doi: 10.1212/01.wnl.0000267425.51598.c9. PMID: 17698789

Recent clinical studies

Etiology

Efficacy and Safety of DaxibotulinumtoxinA for Injection in Cervical Dystonia: ASPEN-1 Phase 3 Randomized Controlled Trial.
Comella CL, Jankovic J, Hauser RA, Patel AT, Banach MD, Ehler E, Vitarella D, Rubio RG, Gross TM; ASPEN-1 Study Group
Neurology 2024 Feb 27;102(4):e208091. Epub 2024 Jan 31 doi: 10.1212/WNL.0000000000208091. PMID: 38295339Free PMC Article
Adult-onset focal dystonias: To lump or split.
Jinnah HA, DeFazio G
Int Rev Neurobiol 2023;169:317-327. Epub 2023 Apr 20 doi: 10.1016/bs.irn.2023.04.001. PMID: 37482396
Isolated Cervical Dystonia: Diagnosis and Classification.
Albanese A, Bhatia KP, Cardoso F, Comella C, Defazio G, Fung VSC, Hallett M, Jankovic J, Jinnah HA, Kaji R, Krauss JK, Lang A, Tan EK, Tijssen MAJ, Vidailhet M
Mov Disord 2023 Aug;38(8):1367-1378. Epub 2023 Mar 29 doi: 10.1002/mds.29387. PMID: 36989390Free PMC Article
Clinical Practice Guideline: Hoarseness (Dysphonia) (Update).
Stachler RJ, Francis DO, Schwartz SR, Damask CC, Digoy GP, Krouse HJ, McCoy SJ, Ouellette DR, Patel RR, Reavis CCW, Smith LJ, Smith M, Strode SW, Woo P, Nnacheta LC
Otolaryngol Head Neck Surg 2018 Mar;158(1_suppl):S1-S42. doi: 10.1177/0194599817751030. PMID: 29494321
Nonprimary dystonias.
Dressler D
Handb Clin Neurol 2011;100:513-38. doi: 10.1016/B978-0-444-52014-2.00038-0. PMID: 21496605

Diagnosis

Genetic Update and Treatment for Dystonia.
Koptielow J, Szyłak E, Szewczyk-Roszczenko O, Roszczenko P, Kochanowicz J, Kułakowska A, Chorąży M
Int J Mol Sci 2024 Mar 22;25(7) doi: 10.3390/ijms25073571. PMID: 38612382Free PMC Article
Isolated Cervical Dystonia: Diagnosis and Classification.
Albanese A, Bhatia KP, Cardoso F, Comella C, Defazio G, Fung VSC, Hallett M, Jankovic J, Jinnah HA, Kaji R, Krauss JK, Lang A, Tan EK, Tijssen MAJ, Vidailhet M
Mov Disord 2023 Aug;38(8):1367-1378. Epub 2023 Mar 29 doi: 10.1002/mds.29387. PMID: 36989390Free PMC Article
Cervical dystonia - improving the effectiveness of botulinum toxin therapy.
Tyślerowicz M, Kiedrzyńska W, Adamkiewicz B, Jost WH, Sławek J
Neurol Neurochir Pol 2020;54(3):232-242. Epub 2020 Apr 14 doi: 10.5603/PJNNS.a2020.0021. PMID: 32285434
Clinical Practice Guideline: Hoarseness (Dysphonia) (Update).
Stachler RJ, Francis DO, Schwartz SR, Damask CC, Digoy GP, Krouse HJ, McCoy SJ, Ouellette DR, Patel RR, Reavis CCW, Smith LJ, Smith M, Strode SW, Woo P, Nnacheta LC
Otolaryngol Head Neck Surg 2018 Mar;158(1_suppl):S1-S42. doi: 10.1177/0194599817751030. PMID: 29494321
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

Therapy

Botulinum toxin therapy of dystonia.
Dressler D, Adib Saberi F, Rosales RL
J Neural Transm (Vienna) 2021 Apr;128(4):531-537. Epub 2020 Oct 30 doi: 10.1007/s00702-020-02266-z. PMID: 33125571Free PMC Article
Cervical dystonia - improving the effectiveness of botulinum toxin therapy.
Tyślerowicz M, Kiedrzyńska W, Adamkiewicz B, Jost WH, Sławek J
Neurol Neurochir Pol 2020;54(3):232-242. Epub 2020 Apr 14 doi: 10.5603/PJNNS.a2020.0021. PMID: 32285434
Clinical Practice Guideline: Hoarseness (Dysphonia) (Update).
Stachler RJ, Francis DO, Schwartz SR, Damask CC, Digoy GP, Krouse HJ, McCoy SJ, Ouellette DR, Patel RR, Reavis CCW, Smith LJ, Smith M, Strode SW, Woo P, Nnacheta LC
Otolaryngol Head Neck Surg 2018 Mar;158(1_suppl):S1-S42. doi: 10.1177/0194599817751030. PMID: 29494321
Conversion Ratio between Botox®, Dysport®, and Xeomin® in Clinical Practice.
Scaglione F
Toxins (Basel) 2016 Mar 4;8(3) doi: 10.3390/toxins8030065. PMID: 26959061Free PMC Article
Anterocollis and anterocaput.
Finsterer J, Revuelta GJ
Clin Neurol Neurosurg 2014 Dec;127:44-53. Epub 2014 Oct 2 doi: 10.1016/j.clineuro.2014.09.020. PMID: 25459242

Prognosis

Botulinum toxin therapy of dystonia.
Dressler D, Adib Saberi F, Rosales RL
J Neural Transm (Vienna) 2021 Apr;128(4):531-537. Epub 2020 Oct 30 doi: 10.1007/s00702-020-02266-z. PMID: 33125571Free PMC Article
Deep brain stimulation in dystonia: State of art and future directions.
Macerollo A, Sajin V, Bonello M, Barghava D, Alusi SH, Eldridge PR, Osman-Farah J
J Neurosci Methods 2020 Jul 1;340:108750. Epub 2020 Apr 25 doi: 10.1016/j.jneumeth.2020.108750. PMID: 32344043
Update on KMT2B-Related Dystonia.
Zech M, Lam DD, Winkelmann J
Curr Neurol Neurosci Rep 2019 Nov 25;19(11):92. doi: 10.1007/s11910-019-1007-y. PMID: 31768667
Surgery for Dystonia and Tremor.
Crowell JL, Shah BB
Curr Neurol Neurosci Rep 2016 Mar;16(3):22. doi: 10.1007/s11910-016-0627-8. PMID: 26838349
The prevalence of primary dystonia: a systematic review and meta-analysis.
Steeves TD, Day L, Dykeman J, Jette N, Pringsheim T
Mov Disord 2012 Dec;27(14):1789-96. Epub 2012 Oct 31 doi: 10.1002/mds.25244. PMID: 23114997

Clinical prediction guides

Efficacy and Safety of DaxibotulinumtoxinA for Injection in Cervical Dystonia: ASPEN-1 Phase 3 Randomized Controlled Trial.
Comella CL, Jankovic J, Hauser RA, Patel AT, Banach MD, Ehler E, Vitarella D, Rubio RG, Gross TM; ASPEN-1 Study Group
Neurology 2024 Feb 27;102(4):e208091. Epub 2024 Jan 31 doi: 10.1212/WNL.0000000000208091. PMID: 38295339Free PMC Article
Isolated Cervical Dystonia: Diagnosis and Classification.
Albanese A, Bhatia KP, Cardoso F, Comella C, Defazio G, Fung VSC, Hallett M, Jankovic J, Jinnah HA, Kaji R, Krauss JK, Lang A, Tan EK, Tijssen MAJ, Vidailhet M
Mov Disord 2023 Aug;38(8):1367-1378. Epub 2023 Mar 29 doi: 10.1002/mds.29387. PMID: 36989390Free PMC Article
Botulinum toxin therapy of dystonia.
Dressler D, Adib Saberi F, Rosales RL
J Neural Transm (Vienna) 2021 Apr;128(4):531-537. Epub 2020 Oct 30 doi: 10.1007/s00702-020-02266-z. PMID: 33125571Free PMC Article
Deep brain stimulation in dystonia: State of art and future directions.
Macerollo A, Sajin V, Bonello M, Barghava D, Alusi SH, Eldridge PR, Osman-Farah J
J Neurosci Methods 2020 Jul 1;340:108750. Epub 2020 Apr 25 doi: 10.1016/j.jneumeth.2020.108750. PMID: 32344043
Clinical Practice Guideline: Hoarseness (Dysphonia) (Update).
Stachler RJ, Francis DO, Schwartz SR, Damask CC, Digoy GP, Krouse HJ, McCoy SJ, Ouellette DR, Patel RR, Reavis CCW, Smith LJ, Smith M, Strode SW, Woo P, Nnacheta LC
Otolaryngol Head Neck Surg 2018 Mar;158(1_suppl):S1-S42. doi: 10.1177/0194599817751030. PMID: 29494321

Recent systematic reviews

Cortical neurophysiology of primary isolated dystonia and non-dystonic adults: A meta-analysis.
McCambridge AB, Bradnam LV
Eur J Neurosci 2021 Feb;53(4):1300-1323. Epub 2020 Oct 27 doi: 10.1111/ejn.14987. PMID: 32991762
Remission in dystonia - Systematic review of the literature and meta-analysis.
Mainka T, Erro R, Rothwell J, Kühn AA, Bhatia KP, Ganos C
Parkinsonism Relat Disord 2019 Sep;66:9-15. Epub 2019 Feb 16 doi: 10.1016/j.parkreldis.2019.02.020. PMID: 30898428
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678
Behavioural interventions for people living with adult-onset primary dystonia: a systematic review.
Bernstein CJ, Ellard DR, Davies G, Hertenstein E, Tang NK, Underwood M, Sandhu H
BMC Neurol 2016 Mar 22;16:40. doi: 10.1186/s12883-016-0562-y. PMID: 27000094Free PMC Article
The prevalence of primary dystonia: a systematic review and meta-analysis.
Steeves TD, Day L, Dykeman J, Jette N, Pringsheim T
Mov Disord 2012 Dec;27(14):1789-96. Epub 2012 Oct 31 doi: 10.1002/mds.25244. PMID: 23114997

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...