Mutation in the HCN2 gene can cause a spectrum of seizure disorders beginning in childhood or adolescence. Affected individuals may have simple febrile seizures or more complex afebrile seizures, including tonic-clonic, myoclonic, and photosensitive. Rare patients may have mild intellectual disability or behavioral problems (summary by Li et al., 2018).
For a general phenotypic description and a discussion of genetic heterogeneity of idiopathic generalized epilepsy, see EIG (600669).
For a phenotypic description and a discussion of genetic heterogeneity of familial febrile seizures, see FEB1 (121210).
For a general phenotypic description and a discussion of genetic heterogeneity of GEFS+, see 604233. [from
OMIM]