U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nonsyndromic cleft lip with or without cleft palate

MedGen UID:
349304
•Concept ID:
C1861538
•
Finding

Professional guidelines

PubMed

Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.
Kang G, Baek SH, Kim YH, Kim DH, Park JW
Int J Mol Sci 2023 Feb 25;24(5) doi: 10.3390/ijms24054557. PMID: 36901988Free PMC Article
Maternal genotypes of folate/one-carbon metabolism gene variants and nonsyndromic cleft lip with or without cleft palate risk in Chile.
Inostroza V, Salamanca C, Recabarren AS, Pantoja R, Leiva N, Pardo R, Suazo J
Eur J Oral Sci 2021 Oct;129(5):e12813. Epub 2021 Jul 21 doi: 10.1111/eos.12813. PMID: 34289180
Exploratory genotype-phenotype correlations of facial form and asymmetry in unaffected relatives of children with non-syndromic cleft lip and/or palate.
Miller SF, Weinberg SM, Nidey NL, Defay DK, Marazita ML, Wehby GL, Moreno Uribe LM
J Anat 2014 Jun;224(6):688-709. Epub 2014 Apr 16 doi: 10.1111/joa.12182. PMID: 24738728Free PMC Article

Recent clinical studies

Etiology

Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.
Kang G, Baek SH, Kim YH, Kim DH, Park JW
Int J Mol Sci 2023 Feb 25;24(5) doi: 10.3390/ijms24054557. PMID: 36901988Free PMC Article
PEMT variants are associated with nonsyndromic cleft lip with or without cleft palate in Chile.
Suazo J, Salamanca C, González-Hormazábal P, Cáceres-Rojas G, Pantoja R, Leiva N, Pardo R
Epigenomics 2022 Sep;14(17):987-993. Epub 2022 Sep 26 doi: 10.2217/epi-2022-0180. PMID: 36154674
Current concepts on cleft lip and palate etiology.
Candotto V, Oberti L, Gabrione F, Greco G, Rossi D, Romano M, Mummolo S
J Biol Regul Homeost Agents 2019 May-Jun;33(3 Suppl. 1):145-151. DENTAL SUPPLEMENT. PMID: 31538461
Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis.
Xia Y, Hu B, Chen J, Zheng L, Song J
Arch Oral Biol 2017 Dec;84:161-168. Epub 2017 Oct 2 doi: 10.1016/j.archoralbio.2017.09.032. PMID: 29017114
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Machado RA, Moreira HSB, de Aquino SN, Martelli-Junior H, de Almeida Reis SR, Persuhn DC, Wu T, Yuan Y, Coletta RD
Am J Med Genet A 2016 Feb;170A(2):536-539. Epub 2015 Oct 27 doi: 10.1002/ajmg.a.37281. PMID: 26507587

Diagnosis

Using whole exome sequencing to identify susceptibility genes associated with nonsyndromic cleft lip with or without cleft palate.
Fu Z, Yue J, Xue L, Xu Y, Ding Q, Xiao W
Mol Genet Genomics 2023 Jan;298(1):107-118. Epub 2022 Nov 2 doi: 10.1007/s00438-022-01967-2. PMID: 36322204
A novel splicing mutation of ARHGAP29 is associated with nonsyndromic cleft lip with or without cleft palate.
Yu Q, Deng Q, Fu F, Li R, Zhang W, Wan J, Yang X, Wang D, Li F, Wu S, Li J, Li D, Liao C
J Matern Fetal Neonatal Med 2022 Jul;35(13):2499-2506. Epub 2020 Jul 22 doi: 10.1080/14767058.2020.1786523. PMID: 32698641
SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.
Li Q, Xu L, Jia X, Saleem K, Zaib T, Sun W, Fu S
Biosci Rep 2020 Mar 27;40(3) doi: 10.1042/BSR20194261. PMID: 32124929Free PMC Article
Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis.
Xia Y, Hu B, Chen J, Zheng L, Song J
Arch Oral Biol 2017 Dec;84:161-168. Epub 2017 Oct 2 doi: 10.1016/j.archoralbio.2017.09.032. PMID: 29017114
BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis.
Li YH, Yang J, Zhang JL, Liu JQ, Zheng Z, Hu DH
Medicine (Baltimore) 2017 Aug;96(31):e7676. doi: 10.1097/MD.0000000000007676. PMID: 28767592Free PMC Article

Therapy

Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.
Kang G, Baek SH, Kim YH, Kim DH, Park JW
Int J Mol Sci 2023 Feb 25;24(5) doi: 10.3390/ijms24054557. PMID: 36901988Free PMC Article
Current concepts on cleft lip and palate etiology.
Candotto V, Oberti L, Gabrione F, Greco G, Rossi D, Romano M, Mummolo S
J Biol Regul Homeost Agents 2019 May-Jun;33(3 Suppl. 1):145-151. DENTAL SUPPLEMENT. PMID: 31538461
Gene-gene interaction between MSX1 and TP63 in Asian case-parent trios with nonsyndromic cleft lip with or without cleft palate.
Liu D, Schwender H, Wang M, Wang H, Wang P, Zhu H, Zhou Z, Li J, Wu T, Beaty TH
Birth Defects Res 2018 Mar 1;110(4):317-324. Epub 2018 Jan 17 doi: 10.1002/bdr2.1139. PMID: 29341488
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Machado RA, Moreira HSB, de Aquino SN, Martelli-Junior H, de Almeida Reis SR, Persuhn DC, Wu T, Yuan Y, Coletta RD
Am J Med Genet A 2016 Feb;170A(2):536-539. Epub 2015 Oct 27 doi: 10.1002/ajmg.a.37281. PMID: 26507587
Nonsyndromic cleft lip with or without cleft palate in arab populations: genetic analysis of 15 risk loci in a novel case-control sample recruited in Yemen.
Aldhorae KA, Böhmer AC, Ludwig KU, Esmail AH, Al-Hebshi NN, Lippke B, Gölz L, Nöthen MM, Daratsianos N, Knapp M, Jäger A, Mangold E
Birth Defects Res A Clin Mol Teratol 2014 Apr;100(4):307-13. Epub 2014 Mar 13 doi: 10.1002/bdra.23221. PMID: 24634360

Prognosis

Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.
Kang G, Baek SH, Kim YH, Kim DH, Park JW
Int J Mol Sci 2023 Feb 25;24(5) doi: 10.3390/ijms24054557. PMID: 36901988Free PMC Article
Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.
Salamanca C, González-Hormazábal P, Recabarren AS, Recabarren PA, Pantoja R, Leiva N, Pardo R, Suazo J
Pediatr Res 2021 Mar;89(4):1020-1025. Epub 2020 Jun 3 doi: 10.1038/s41390-020-0994-3. PMID: 32492698
Association Between IRF6 Variants and Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile.
Suazo J, Recabarren AS, Marín NR, Blanco R
Reprod Sci 2020 Oct;27(10):1857-1862. Epub 2020 Jun 12 doi: 10.1007/s43032-020-00203-9. PMID: 32533457
Association of WNT Pathway Genes With Nonsyndromic Cleft Lip With or Without Cleft Palate.
Vijayan V, Ummer R, Weber R, Silva R, Letra A
Cleft Palate Craniofac J 2018 Mar;55(3):335-341. Epub 2017 Dec 14 doi: 10.1177/1055665617732782. PMID: 29437498
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta-analysis.
Wattanawong K, Rattanasiri S, McEvoy M, Attia J, Thakkinstian A
Birth Defects Res A Clin Mol Teratol 2016 Sep;106(9):773-88. Epub 2016 Aug 11 doi: 10.1002/bdra.23540. PMID: 27511269Free PMC Article

Clinical prediction guides

Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.
Kang G, Baek SH, Kim YH, Kim DH, Park JW
Int J Mol Sci 2023 Feb 25;24(5) doi: 10.3390/ijms24054557. PMID: 36901988Free PMC Article
Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.
Salamanca C, González-Hormazábal P, Recabarren AS, Recabarren PA, Pantoja R, Leiva N, Pardo R, Suazo J
Pediatr Res 2021 Mar;89(4):1020-1025. Epub 2020 Jun 3 doi: 10.1038/s41390-020-0994-3. PMID: 32492698
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta-analysis.
Wattanawong K, Rattanasiri S, McEvoy M, Attia J, Thakkinstian A
Birth Defects Res A Clin Mol Teratol 2016 Sep;106(9):773-88. Epub 2016 Aug 11 doi: 10.1002/bdra.23540. PMID: 27511269Free PMC Article
Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate.
Song T, Shi J, Guo Q, Lv K, Jiao X, Hu T, Sun X, Fu S
Am J Med Genet A 2015 Jan;167A(1):137-41. Epub 2014 Oct 22 doi: 10.1002/ajmg.a.36802. PMID: 25339627
Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations.
Park JW, McIntosh I, Hetmanski JB, Jabs EW, Vander Kolk CA, Wu-Chou YH, Chen PK, Chong SS, Yeow V, Jee SH, Park BY, Fallin MD, Ingersoll R, Scott AF, Beaty TH
Genet Med 2007 Apr;9(4):219-27. doi: 10.1097/gim.0b013e3180423cca. PMID: 17438386Free PMC Article

Recent systematic reviews

Association of Fetal MTHFR 677C > T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis.
Amooee A, Dastgheib SA, Niktabar SM, Noorishadkam M, Lookzadeh MH, Mirjalili SR, Heiranizadeh N, Neamatzadeh H
Fetal Pediatr Pathol 2021 Aug;40(4):337-353. Epub 2019 Dec 27 doi: 10.1080/15513815.2019.1707918. PMID: 31880477
Potential genetic markers for nonsyndromic oral clefts in the Brazilian population: A systematic review and meta-analysis.
Assis Machado R, de Toledo IP, Martelli-Júnior H, Reis SR, Neves Silva Guerra E, Coletta RD
Birth Defects Res 2018 Jun 1;110(10):827-839. Epub 2018 Feb 15 doi: 10.1002/bdr2.1208. PMID: 29446255
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta-analysis.
Wattanawong K, Rattanasiri S, McEvoy M, Attia J, Thakkinstian A
Birth Defects Res A Clin Mol Teratol 2016 Sep;106(9):773-88. Epub 2016 Aug 11 doi: 10.1002/bdra.23540. PMID: 27511269Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...