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Decreased circulating alkaline phosphatase activity

MedGen UID:
349734
•Concept ID:
C1860130
•
Finding
Synonyms: Decreased serum alkaline phosphatase; Low alkaline phosphatase
 
HPO: HP:0003282

Definition

Concentration or activity of alkaline phosphatase outside the upper or lower limtis of normal in the blood circulation. [from HPO]

Professional guidelines

PubMed

Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget's disease of bone.
Martini G, Gennari L, Merlotti D, Salvadori S, Franci MB, Campagna S, Avanzati A, De Paola V, Valleggi F, Nuti R
Bone 2007 Feb;40(2):457-63. Epub 2006 Sep 18 doi: 10.1016/j.bone.2006.08.003. PMID: 16979395
Circulating osteoprotegerin in women during GnRH-agonist treatment and their relationships with mineral components and biomarkers of bone turnover.
Uemura H, Yasui T, Umino Y, Niki H, Takikawa M, Saito S, Furumoto H, Irahara M
Bone 2003 Nov;33(5):860-6. doi: 10.1016/j.bone.2003.08.001. PMID: 14623063
The acute effect of high dose corticosteroid treatment on serum osteocalcin.
Ekenstam E, Stålenheim G, Hällgren R
Metabolism 1988 Feb;37(2):141-4. doi: 10.1016/s0026-0495(98)90008-7. PMID: 3257542

Recent clinical studies

Etiology

The effect of intradialytic exercise on calcium, phosphorus and parathyroid hormone: a randomized controlled trial.
Tabibi MA, Wilund KR, Salimian N, Nikbakht S, Soleymany M, Roshanaeian Z, Nazemi F, Ahmadi S
BMC Nephrol 2023 Sep 20;24(1):276. doi: 10.1186/s12882-023-03327-7. PMID: 37730530Free PMC Article
The Non-invasive Diagnosis of Bone Disorders in CKD.
Bover J, Ureña-Torres P, Cozzolino M, Rodríguez-García M, Gómez-Alonso C
Calcif Tissue Int 2021 Apr;108(4):512-527. Epub 2021 Jan 4 doi: 10.1007/s00223-020-00781-5. PMID: 33398414
Supplementary Energy Increases Bone Formation during Arduous Military Training.
O'Leary TJ, Walsh NP, Casey A, Izard RM, Tang JCY, Fraser WD, Greeves JP
Med Sci Sports Exerc 2021 Feb 1;53(2):394-403. doi: 10.1249/MSS.0000000000002473. PMID: 32701874
Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
Metabolic effects of alcohol.
Mezey E
Fed Proc 1985 Jan;44(1 Pt 1):134-8. PMID: 3881285

Diagnosis

Systems biomarker characteristics of circulating alkaline phosphatase activities for 48 types of human diseases.
Su W, Qiu T, Zhang M, Hao C, Zeng P, Huang Z, Du W, Yun T, Xuan Y, Zhang L, Guo Y, Jiao W
Curr Med Res Opin 2022 Feb;38(2):201-209. Epub 2021 Nov 12 doi: 10.1080/03007995.2021.2000715. PMID: 34719310
The Non-invasive Diagnosis of Bone Disorders in CKD.
Bover J, Ureña-Torres P, Cozzolino M, Rodríguez-García M, Gómez-Alonso C
Calcif Tissue Int 2021 Apr;108(4):512-527. Epub 2021 Jan 4 doi: 10.1007/s00223-020-00781-5. PMID: 33398414
Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population.
Cauwenberghs N, Ravassa S, Thijs L, Haddad F, Yang WY, Wei FF, López B, González A, Díez J, Staessen JA, Kuznetsova T
J Am Heart Assoc 2019 Jan 22;8(2):e010430. doi: 10.1161/JAHA.118.010430. PMID: 30638123Free PMC Article
Markers of bone turnover in bone metastases.
Fontana A, Delmas PD
Cancer 2000 Jun 15;88(12 Suppl):2952-60. doi: 10.1002/1097-0142(20000615)88:12+<2952::aid-cncr11>3.0.co;2-m. PMID: 10898339
Adult hypophosphatasia.
Sorensen E, Flodgaard H
Acta Med Scand 1975 May;197(5):357-60. doi: 10.1111/j.0954-6820.1975.tb04934.x. PMID: 167553

Therapy

Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia.
Seefried L, Kishnani PS, Moseley S, Denker AE, Watsky E, Whyte MP, Dahir KM
Bone 2021 Jan;142:115664. Epub 2020 Sep 26 doi: 10.1016/j.bone.2020.115664. PMID: 32987199
Supplementary Energy Increases Bone Formation during Arduous Military Training.
O'Leary TJ, Walsh NP, Casey A, Izard RM, Tang JCY, Fraser WD, Greeves JP
Med Sci Sports Exerc 2021 Feb 1;53(2):394-403. doi: 10.1249/MSS.0000000000002473. PMID: 32701874
Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer's disease and neurodegeneration.
Pike AF, Kramer NI, Blaauboer BJ, Seinen W, Brands R
Chem Biol Interact 2015 Jan 25;226:30-9. Epub 2014 Dec 11 doi: 10.1016/j.cbi.2014.12.006. PMID: 25500268
Curcumin and chronic kidney disease (CKD): major mode of action through stimulating endogenous intestinal alkaline phosphatase.
Ghosh SS, Gehr TW, Ghosh S
Molecules 2014 Dec 2;19(12):20139-56. doi: 10.3390/molecules191220139. PMID: 25474287Free PMC Article

Prognosis

Circulating 25-hydroxycholecalciferol and calcium levels, and alkaline phosphatase activity among people living with and without human immunodeficiency virus and injecting drugs in kenya.
Onyango AO, Shaviya N, Budambula V, Orinda GO, Anzala O, Aabid AA, Were T
BMC Infect Dis 2024 Jul 17;24(1):703. doi: 10.1186/s12879-024-09610-8. PMID: 39020290Free PMC Article
Supplementary Energy Increases Bone Formation during Arduous Military Training.
O'Leary TJ, Walsh NP, Casey A, Izard RM, Tang JCY, Fraser WD, Greeves JP
Med Sci Sports Exerc 2021 Feb 1;53(2):394-403. doi: 10.1249/MSS.0000000000002473. PMID: 32701874
Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population.
Cauwenberghs N, Ravassa S, Thijs L, Haddad F, Yang WY, Wei FF, López B, González A, Díez J, Staessen JA, Kuznetsova T
J Am Heart Assoc 2019 Jan 22;8(2):e010430. doi: 10.1161/JAHA.118.010430. PMID: 30638123Free PMC Article
Bone metabolism markers and angiogenic cytokines as regulators of human hematopoietic stem cell mobilization.
Tsirkinidis P, Terpos E, Boutsikas G, Papatheodorou A, Anargyrou K, Lalou E, Dimitrakopoulou A, Kalpadakis C, Konstantopoulos K, Siakantaris M, Panayiotidis P, Pangalis G, Kyrtsonis MC, Vassilakopoulos T, Angelopoulou MK
J Bone Miner Metab 2018 Jul;36(4):399-409. Epub 2017 Jun 28 doi: 10.1007/s00774-017-0853-4. PMID: 28660376
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer.
Rao SR, Snaith AE, Marino D, Cheng X, Lwin ST, Orriss IR, Hamdy FC, Edwards CM
Br J Cancer 2017 Jan 17;116(2):227-236. Epub 2016 Dec 22 doi: 10.1038/bjc.2016.402. PMID: 28006818Free PMC Article

Clinical prediction guides

Circulating 25-hydroxycholecalciferol and calcium levels, and alkaline phosphatase activity among people living with and without human immunodeficiency virus and injecting drugs in kenya.
Onyango AO, Shaviya N, Budambula V, Orinda GO, Anzala O, Aabid AA, Were T
BMC Infect Dis 2024 Jul 17;24(1):703. doi: 10.1186/s12879-024-09610-8. PMID: 39020290Free PMC Article
The direct impact of pegvisomant on osteoblast functions and bone development.
Vitali E, Grasso A, Schiavone ML, Trivellin G, Sobacchi C, Mione M, Mazziotti G, Lania A
J Endocrinol Invest 2024 Jun;47(6):1385-1394. Epub 2023 Dec 30 doi: 10.1007/s40618-023-02281-3. PMID: 38159174
The effect of intradialytic exercise on calcium, phosphorus and parathyroid hormone: a randomized controlled trial.
Tabibi MA, Wilund KR, Salimian N, Nikbakht S, Soleymany M, Roshanaeian Z, Nazemi F, Ahmadi S
BMC Nephrol 2023 Sep 20;24(1):276. doi: 10.1186/s12882-023-03327-7. PMID: 37730530Free PMC Article
Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression.
Tang X, Lin J, Wang G, Lu J
PLoS One 2017;12(6):e0179860. Epub 2017 Jun 19 doi: 10.1371/journal.pone.0179860. PMID: 28628652Free PMC Article

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