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Susceptibility to severe cutaneous adverse reaction

MedGen UID:
326760
•Concept ID:
C1840548
•
Finding
Synonym: SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO
 
Genes (locations): HLA-A (6p22.1); HLA-B (6p21.33)
 
OMIM®: 608579

Professional guidelines

PubMed

Update on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management.
Shah H, Parisi R, Mukherjee E, Phillips EJ, Dodiuk-Gad RP
Am J Clin Dermatol 2024 Nov;25(6):891-908. Epub 2024 Sep 15 doi: 10.1007/s40257-024-00889-6. PMID: 39278968Free PMC Article
Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis.
Hadavand MA, Kaffenberger B, Cartron AM, Trinidad JCL
J Am Acad Dermatol 2022 Sep;87(3):632-639. Epub 2020 Sep 11 doi: 10.1016/j.jaad.2020.09.024. PMID: 32926975
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444

Recent clinical studies

Etiology

HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients.
Capule F, Tragulpiankit P, Mahasirimongkol S, Jittikoon J, Wichukchinda N, Alentajan-Aleta LT, Barit JJ, Casanova-Gutierrez J, Cabral-Lim L, Baltazar Reyes JP, Roa F, Salonga R, San Gabriel KF, Silao CL
Pharmacogenomics 2021 Jun;22(8):465-472. Epub 2021 Apr 29 doi: 10.2217/pgs-2020-0191. PMID: 33910375Free PMC Article
Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN).
Kuijper EC, French LE, Tensen CP, Vermeer MH, Bouwes Bavinck JN
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1957-1971. Epub 2020 May 15 doi: 10.1111/jdv.16339. PMID: 32415695Free PMC Article
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.
Wang CW, Dao RL, Chung WH
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):339-45. doi: 10.1097/ACI.0000000000000286. PMID: 27362322
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Diagnosis

Update on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management.
Shah H, Parisi R, Mukherjee E, Phillips EJ, Dodiuk-Gad RP
Am J Clin Dermatol 2024 Nov;25(6):891-908. Epub 2024 Sep 15 doi: 10.1007/s40257-024-00889-6. PMID: 39278968Free PMC Article
Cytokines/Chemokines: Novel Biomarkers Associated with Severe Cutaneous Adverse Reactions.
Zhang X, Lu WS, Qin XM
J Interferon Cytokine Res 2020 Apr;40(4):172-181. Epub 2020 Mar 20 doi: 10.1089/jir.2019.0012. PMID: 32195616
Making a diagnosis in severe cutaneous drug hypersensitivity reactions.
Ardern-Jones MR, Mockenhaupt M
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):283-293. doi: 10.1097/ACI.0000000000000546. PMID: 31247634
DRESS syndrome.
Descamps V, Ranger-Rogez S
Joint Bone Spine 2014 Jan;81(1):15-21. Epub 2013 Jun 29 doi: 10.1016/j.jbspin.2013.05.002. PMID: 23816504
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Therapy

Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
HLA-A*31:01 and lamotrigine-induced severe cutaneous adverse drug reactions in a Korean population.
Kim BK, Jung JW, Kim TB, Chang YS, Park HS, Moon J, Lee ST, Jung KH, Jung KY, Chu K, Lee SK, Kang HR, Park HW
Ann Allergy Asthma Immunol 2017 May;118(5):629-630. Epub 2017 Mar 25 doi: 10.1016/j.anai.2017.02.011. PMID: 28351624
Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article
Allopurinol in dermatology.
Tsai TF, Yeh TY
Am J Clin Dermatol 2010;11(4):225-32. doi: 10.2165/11533190-000000000-00000. PMID: 20509717

Prognosis

Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.
Wang CW, Dao RL, Chung WH
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):339-45. doi: 10.1097/ACI.0000000000000286. PMID: 27362322
Adverse cutaneous drug eruptions: current understanding.
Hoetzenecker W, Nägeli M, Mehra ET, Jensen AN, Saulite I, Schmid-Grendelmeier P, Guenova E, Cozzio A, French LE
Semin Immunopathol 2016 Jan;38(1):75-86. Epub 2015 Nov 9 doi: 10.1007/s00281-015-0540-2. PMID: 26553194
DRESS syndrome.
Descamps V, Ranger-Rogez S
Joint Bone Spine 2014 Jan;81(1):15-21. Epub 2013 Jun 29 doi: 10.1016/j.jbspin.2013.05.002. PMID: 23816504
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Clinical prediction guides

Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.
Negrini S, Becquemont L
Pharmacogenomics 2017 Oct;18(15):1441-1457. Epub 2017 Oct 11 doi: 10.2217/pgs-2017-0090. PMID: 29017379
Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Kaniwa N, Saito Y
J Hum Genet 2013 Jun;58(6):317-26. Epub 2013 May 2 doi: 10.1038/jhg.2013.37. PMID: 23635947
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Recent systematic reviews

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.
Alfares I, Javaid MS, Chen Z, Anderson A, Antonic-Baker A, Kwan P
CNS Drugs 2021 Feb;35(2):161-176. Epub 2021 Feb 12 doi: 10.1007/s40263-021-00794-0. PMID: 33580477
HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.
Tangamornsuksan W, Chanprasert S, Nadee P, Rungruang S, Meesilsat N, Ueta M, Lohitnavy M
Sci Rep 2020 Jun 29;10(1):10589. doi: 10.1038/s41598-020-67610-5. PMID: 32601360Free PMC Article
HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.
Grover S, Kukreti R
Pharmacogenet Genomics 2014 Feb;24(2):94-112. doi: 10.1097/FPC.0000000000000021. PMID: 24336023

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