U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IgE responsiveness, atopic(IGEL; IGER)

MedGen UID:
327063
•Concept ID:
C1840253
•
Disease or Syndrome
Synonym: IMMUNOGLOBULIN E, BASIC LEVEL OF, IN SERUM
 
Monarch Initiative: MONDO:0007817
OMIM®: 147050

Definition

Atopy is an allergic disorder characterized by immunoglobulin E (IgE) responses to environmental proteins that are otherwise innocuous and predominantly found in plant pollen and house dust. It is the major cause of asthma (see 600807), rhinitis (see 607154), and eczema (see 603165) in children and young adults (summary by Young et al., 1992). [from OMIM]

Clinical features

From HPO
Asthma
MedGen UID:
2109
•Concept ID:
C0004096
•
Disease or Syndrome
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
See: Feature record | Search on this feature
Eczematoid dermatitis
MedGen UID:
3968
•Concept ID:
C0013595
•
Disease or Syndrome
Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
See: Feature record | Search on this feature
Increased circulating IgE concentration
MedGen UID:
116018
•Concept ID:
C0236175
•
Finding
An abnormally increased overall level of immunoglobulin E in blood.
See: Feature record | Search on this feature
Allergic rhinitis
MedGen UID:
382012
•Concept ID:
C2607914
•
Disease or Syndrome
It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation.
Busse WW, Kraft M, Rabe KF, Deniz Y, Rowe PJ, Ruddy M, Castro M
Eur Respir J 2021 Aug;58(2) Epub 2021 Aug 5 doi: 10.1183/13993003.03393-2020. PMID: 33542055Free PMC Article
EAACI Molecular Allergology User's Guide.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, EIgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M
Pediatr Allergy Immunol 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617

Recent clinical studies

Etiology

Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events.
Geba GP, Li D, Xu M, Mohammadi K, Attre R, Ardeleanu M, Musser B
J Allergy Clin Immunol 2023 Mar;151(3):756-766. Epub 2022 Sep 7 doi: 10.1016/j.jaci.2022.08.026. PMID: 36084766

Therapy

Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events.
Geba GP, Li D, Xu M, Mohammadi K, Attre R, Ardeleanu M, Musser B
J Allergy Clin Immunol 2023 Mar;151(3):756-766. Epub 2022 Sep 7 doi: 10.1016/j.jaci.2022.08.026. PMID: 36084766
Biologic targeted therapy in allergic asthma.
Bice JB, Leechawengwongs E, Montanaro A
Ann Allergy Asthma Immunol 2014 Feb;112(2):108-15. doi: 10.1016/j.anai.2013.12.013. PMID: 24468249

Prognosis

Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events.
Geba GP, Li D, Xu M, Mohammadi K, Attre R, Ardeleanu M, Musser B
J Allergy Clin Immunol 2023 Mar;151(3):756-766. Epub 2022 Sep 7 doi: 10.1016/j.jaci.2022.08.026. PMID: 36084766

Clinical prediction guides

Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events.
Geba GP, Li D, Xu M, Mohammadi K, Attre R, Ardeleanu M, Musser B
J Allergy Clin Immunol 2023 Mar;151(3):756-766. Epub 2022 Sep 7 doi: 10.1016/j.jaci.2022.08.026. PMID: 36084766

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...