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Varicella, severe recurrent

MedGen UID:
322202
Concept ID:
C1833487
Disease or Syndrome
Synonym: Varicella, Severe Recurrent
 
HPO: HP:0005428
Monarch Initiative: MONDO:0010919
OMIM®: 600670

Clinical features

From HPO
Varicella, severe recurrent
MedGen UID:
322202
Concept ID:
C1833487
Disease or Syndrome

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaricella, severe recurrent

Conditions with this feature

Varicella, severe recurrent
MedGen UID:
322202
Concept ID:
C1833487
Disease or Syndrome
Immunodeficiency 62
MedGen UID:
1673905
Concept ID:
C5193109
Disease or Syndrome
Immunodeficiency-62 (IMD62) is an autosomal recessive primary immunologic disorder clinically characterized by onset of recurrent upper and lower respiratory infections late in the first decade of life. Patients may also have increased viral susceptibility to varicella zoster virus (VZV) or herpes simplex virus (HSV). Laboratory studies show impaired antibody response to vaccination, low levels of circulating memory B cells, and almost undetectable antibodies. There is also evidence of secondary T-cell dysfunction. The disorder may result from disturbed actin cytoskeleton dynamics causing impaired lymphocyte migration (summary by Bouafia et al., 2019).

Professional guidelines

PubMed

Beaugerie L, Rahier JF, Kirchgesner J
Clin Gastroenterol Hepatol 2020 May;18(6):1324-1335.e2. Epub 2020 Feb 12 doi: 10.1016/j.cgh.2020.02.009. PMID: 32059920
Ivert LU, Wahlgren CF, Ivert L, Lundqvist M, Bradley M
Acta Derm Venereol 2019 Apr 1;99(4):375-378. doi: 10.2340/00015555-3121. PMID: 30653240
Cohen EJ
Cornea 2015 Oct;34 Suppl 10:S3-8. doi: 10.1097/ICO.0000000000000503. PMID: 26114827

Recent clinical studies

Etiology

Skuhala T, Atelj A, Prepolec J, Al-Mufleh M, Stanimirović A, Vukelić D
BMC Infect Dis 2019 Feb 7;19(1):127. doi: 10.1186/s12879-019-3768-y. PMID: 30732563Free PMC Article

Diagnosis

Skuhala T, Atelj A, Prepolec J, Al-Mufleh M, Stanimirović A, Vukelić D
BMC Infect Dis 2019 Feb 7;19(1):127. doi: 10.1186/s12879-019-3768-y. PMID: 30732563Free PMC Article
Dyer J, Greenfield M
Cutis 2016 Jan;97(1):65-9. PMID: 26919358
Bunyaratavej S, Prasertyothin S, Leeyaphan C
Southeast Asian J Trop Med Public Health 2015 Jan;46(1):27-9. PMID: 26513902

Therapy

Skuhala T, Atelj A, Prepolec J, Al-Mufleh M, Stanimirović A, Vukelić D
BMC Infect Dis 2019 Feb 7;19(1):127. doi: 10.1186/s12879-019-3768-y. PMID: 30732563Free PMC Article

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