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Juvenile nasopharyngeal angiofibroma

MedGen UID:
237137
Concept ID:
C1367536
Neoplastic Process
Synonyms: JNA; Juvenile angiofibroma of nasopharynx; juvenile nasopharyngeal angiofibroma; juvenile nasopharyngeal angiofibroma (disease); Nasopharyngeal Angiofibroma; nasopharyngeal angiofibroma; nasopharyngeal juvenile angiofibroma; Sinonasal Angiofibroma; Sinonasal Tract Angiofibroma
SNOMED CT: Juvenile angiofibroma of nasopharynx (716590006); Juvenile nasopharyngeal angiofibroma (716590006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0030429
Monarch Initiative: MONDO:0017340
Orphanet: ORPHA289596

Definition

A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile nasopharyngeal angiofibroma

Professional guidelines

PubMed

Snyderman CH, Pant H
Otolaryngol Clin North Am 2016 Jun;49(3):791-807. doi: 10.1016/j.otc.2016.02.009. PMID: 27267026
Steinberger SJ, Wetmore RF
Trans Pa Acad Ophthalmol Otolaryngol 1984 Spring;37(1):65-70. PMID: 6330940
Jafek BW, Nahum AM, Butler RM, Ward PH
Laryngoscope 1973 May;83(5):707-20. doi: 10.1288/00005537-197305000-00007. PMID: 4349810

Recent clinical studies

Etiology

Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Meher R, Kathuria S, Wadhwa V, Ali MR, Shah B, Bansal A, Goel P
Am J Otolaryngol 2022 Sep-Oct;43(5):103532. Epub 2022 Jun 11 doi: 10.1016/j.amjoto.2022.103532. PMID: 35714497
Mehan R, Rupa V, Lukka VK, Ahmed M, Moses V, Shyam Kumar NK
Eur Arch Otorhinolaryngol 2016 Dec;273(12):4295-4303. Epub 2016 Jun 11 doi: 10.1007/s00405-016-4136-9. PMID: 27289235
Gates GA, Rice DH, Koopmann CF Jr, Schuller DE
Laryngoscope 1992 Jun;102(6):641-4. doi: 10.1288/00005537-199206000-00009. PMID: 1318484
Malik MK, Kumar A, Bhatia BP
Indian J Med Sci 1991 Dec;45(12):336-42. PMID: 1668094

Diagnosis

Svider P, Arianpour K, Mutchnick S
Pediatr Clin North Am 2018 Jun;65(3):607-621. doi: 10.1016/j.pcl.2018.02.007. PMID: 29803286
Persky M, Tran T
Otolaryngol Clin North Am 2018 Feb;51(1):255-274. Epub 2017 Oct 27 doi: 10.1016/j.otc.2017.09.015. PMID: 29106888
Sessions RB, Zarin DP, Bryan RN
Am J Dis Child 1981 Jun;135(6):535-7. doi: 10.1001/archpedi.1981.02130300035013. PMID: 6263082
Soysa AD, Gnanapragasam J, Dharmaraj RS
Ceylon Med J 1975 Dec;20(4):233-40. PMID: 181152
Hicks JL, Nelson JF
Oral Surg Oral Med Oral Pathol 1973 Jun;35(6):807-17. doi: 10.1016/0030-4220(73)90119-9. PMID: 4350909

Therapy

Snyderman CH, Pant H
Otolaryngol Clin North Am 2016 Jun;49(3):791-807. doi: 10.1016/j.otc.2016.02.009. PMID: 27267026
Schmalbach CE, Gourin C
Otolaryngol Clin North Am 2016 Jun;49(3):777-90. doi: 10.1016/j.otc.2016.03.001. PMID: 27267025
Blount A, Riley KO, Woodworth BA
Otolaryngol Clin North Am 2011 Aug;44(4):989-1004, ix. doi: 10.1016/j.otc.2011.06.003. PMID: 21819885
Christiansen TA, Duvall AJ 3rd, Rosenberg Z, Carley RB
Trans Am Acad Ophthalmol Otolaryngol 1974 May-Jun;78(3):ORL140-7. PMID: 4366255
Wilson WR, Miller D, Lee KJ, Yules RB
Laryngoscope 1972 Jun;82(6):985-97. doi: 10.1288/00005537-197206000-00006. PMID: 4338568

Prognosis

Snyderman CH, Pant H
Otolaryngol Clin North Am 2016 Jun;49(3):791-807. doi: 10.1016/j.otc.2016.02.009. PMID: 27267026
Zito J, Fitzpatrick P, Amedee R
J La State Med Soc 2001 Aug;153(8):395-8. PMID: 11565634
Malik MK, Kumar A, Bhatia BP
Indian J Med Sci 1991 Dec;45(12):336-42. PMID: 1668094
Patterson CN
Otolaryngol Clin North Am 1973 Oct;6(3):839-61. PMID: 4378176
APOSTOL JV, FRAZELL EL
Cancer 1965 Jul;18:869-78. doi: 10.1002/1097-0142(196507)18:7<869::aid-cncr2820180715>3.0.co;2-a. PMID: 14308234

Clinical prediction guides

Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Mishra A, Jaiswal R, Amita P, Mishra SC
Eur Arch Otorhinolaryngol 2019 Jan;276(1):93-100. Epub 2018 Nov 1 doi: 10.1007/s00405-018-5178-y. PMID: 30387011
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985
Gupta AC, Murthy DP
Aust N Z J Surg 1997 Jul;67(7):477-82. doi: 10.1111/j.1445-2197.1997.tb02018.x. PMID: 9236618
Malik MK, Kumar A, Bhatia BP
Indian J Med Sci 1991 Dec;45(12):336-42. PMID: 1668094

Recent systematic reviews

Newman M, Nguyen TBV, McHugh T, Reddy K, Sommer DD
J Otolaryngol Head Neck Surg 2023 Dec 19;52(1):85. doi: 10.1186/s40463-023-00687-w. PMID: 38115030Free PMC Article
Baba A, Kurokawa R, Kurokawa M, Srinivasan A
J Neuroimaging 2023 Sep-Oct;33(5):675-687. Epub 2023 May 10 doi: 10.1111/jon.13116. PMID: 37164909
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Doody J, Adil EA, Trenor CC 3rd, Cunningham MJ
Ann Otol Rhinol Laryngol 2019 Nov;128(11):1061-1072. Epub 2019 May 31 doi: 10.1177/0003489419850194. PMID: 31148463
Khoueir N, Nicolas N, Rohayem Z, Haddad A, Abou Hamad W
Otolaryngol Head Neck Surg 2014 Mar;150(3):350-8. Epub 2013 Dec 31 doi: 10.1177/0194599813516605. PMID: 24381014

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