U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Invasive breast carcinoma

MedGen UID:
163435
•Concept ID:
C0853879
•
Neoplastic Process
Synonyms: BRCA; infiltrating breast cancer; Infiltrating Breast Carcinoma; infiltrating breast carcinoma; Infiltrating Carcinoma of Breast; infiltrating carcinoma of breast; Infiltrating Carcinoma of the Breast; infiltrating carcinoma of the breast; Invasive Breast Cancer; invasive breast cancer; Invasive Breast Carcinoma; invasive breast carcinoma; Invasive carcinoma of breast; Invasive Carcinoma of Breast; invasive carcinoma of breast; Invasive Carcinoma of the Breast; invasive carcinoma of the breast; Invasive Mammary Carcinoma; invasive mammary carcinoma
SNOMED CT: Invasive carcinoma of breast (713609000)
 
Monarch Initiative: MONDO:0006256

Definition

A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Invasive breast carcinoma

Professional guidelines

PubMed

Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective.
Agarwal S, Sau S, Iyer AK, Dixit A, Kashaw SK
Drug Discov Today 2022 Feb;27(2):585-611. Epub 2021 Oct 26 doi: 10.1016/j.drudis.2021.10.008. PMID: 34715356
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Ductal carcinoma in situ: treatment or active surveillance?
Kuerer HM
Expert Rev Anticancer Ther 2015;15(7):777-85. Epub 2015 May 4 doi: 10.1586/14737140.2015.1043897. PMID: 25938920

Recent clinical studies

Etiology

Comparison of HercepTest™ mAb pharmDx (Dako Omnis, GE001) with Ventana PATHWAY anti-HER-2/neu (4B5) in breast cancer: correlation with HER2 amplification and HER2 low status.
Rüschoff J, Friedrich M, Nagelmeier I, Kirchner M, Andresen LM, Salomon K, Portier B, Sredni ST, Schildhaus HU, Jasani B, Grzelinski M, Viale G
Virchows Arch 2022 Nov;481(5):685-694. Epub 2022 Aug 16 doi: 10.1007/s00428-022-03378-5. PMID: 35970977Free PMC Article
Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective.
Agarwal S, Sau S, Iyer AK, Dixit A, Kashaw SK
Drug Discov Today 2022 Feb;27(2):585-611. Epub 2021 Oct 26 doi: 10.1016/j.drudis.2021.10.008. PMID: 34715356
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Sep;24(5):235-251. doi: 10.1097/PAP.0000000000000162. PMID: 28777142Free PMC Article
The prognostic ease and difficulty of invasive breast carcinoma.
Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M, Dumeaux V, Hallett M
Cell Rep 2014 Oct 9;9(1):129-142. Epub 2014 Oct 2 doi: 10.1016/j.celrep.2014.08.073. PMID: 25284793
Atypical hyperplasia: a morphologic risk factor for subsequent development of invasive breast carcinoma.
Tavassoli FA
Cancer Invest 1992;10(5):433-41. doi: 10.3109/07357909209024801. PMID: 1327428

Diagnosis

Dimorphic Invasive Breast Carcinoma with Tubulopapillary Features.
Bezić J, Smolić J, Bečić K
Int J Surg Pathol 2023 Oct;31(7):1314-1316. Epub 2022 Oct 30 doi: 10.1177/10668969221133747. PMID: 36314440
TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Invasive breast carcinoma with osteoclast-like giant cells (OLGC): A rare entity causing diagnostic confusion.
Ofri A, Noushi F, O'Toole S
Breast J 2020 Sep;26(9):1831-1832. Epub 2020 May 18 doi: 10.1111/tbj.13890. PMID: 32419289
The prognostic ease and difficulty of invasive breast carcinoma.
Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M, Dumeaux V, Hallett M
Cell Rep 2014 Oct 9;9(1):129-142. Epub 2014 Oct 2 doi: 10.1016/j.celrep.2014.08.073. PMID: 25284793

Therapy

Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor-Positive Primary Human Breast Tumors.
Kim H, Whitman AA, Wisniewska K, Kakati RT, Garcia-Recio S, Calhoun BC, Franco HL, Perou CM, Spanheimer PM
Clin Cancer Res 2023 Dec 1;29(23):4894-4907. doi: 10.1158/1078-0432.CCR-23-1248. PMID: 37747807Free PMC Article
Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective.
Agarwal S, Sau S, Iyer AK, Dixit A, Kashaw SK
Drug Discov Today 2022 Feb;27(2):585-611. Epub 2021 Oct 26 doi: 10.1016/j.drudis.2021.10.008. PMID: 34715356
Predicting the molecular subtype of breast cancer and identifying interpretable imaging features using machine learning algorithms.
Ma M, Liu R, Wen C, Xu W, Xu Z, Wang S, Wu J, Pan D, Zheng B, Qin G, Chen W
Eur Radiol 2022 Mar;32(3):1652-1662. Epub 2021 Oct 13 doi: 10.1007/s00330-021-08271-4. PMID: 34647174
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer.
Brunt AM, Haviland JS, Sydenham M, Agrawal RK, Algurafi H, Alhasso A, Barrett-Lee P, Bliss P, Bloomfield D, Bowen J, Donovan E, Goodman A, Harnett A, Hogg M, Kumar S, Passant H, Quigley M, Sherwin L, Stewart A, Syndikus I, Tremlett J, Tsang Y, Venables K, Wheatley D, Bliss JM, Yarnold JR
J Clin Oncol 2020 Oct 1;38(28):3261-3272. Epub 2020 Jul 14 doi: 10.1200/JCO.19.02750. PMID: 32663119Free PMC Article
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Prognosis

Incidence, mortality, and disability-adjusted life years of female breast cancer in China, 2022.
Sun K, Zhang B, Lei S, Zheng R, Liang X, Li L, Feng X, Zhang S, Zeng H, Yao Y, Ma P, Wang S, Chen R, Han B, Wei W, He J
Chin Med J (Engl) 2024 Oct 20;137(20):2429-2436. Epub 2024 Sep 5 doi: 10.1097/CM9.0000000000003278. PMID: 39238088Free PMC Article
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer.
Brunt AM, Haviland JS, Sydenham M, Agrawal RK, Algurafi H, Alhasso A, Barrett-Lee P, Bliss P, Bloomfield D, Bowen J, Donovan E, Goodman A, Harnett A, Hogg M, Kumar S, Passant H, Quigley M, Sherwin L, Stewart A, Syndikus I, Tremlett J, Tsang Y, Venables K, Wheatley D, Bliss JM, Yarnold JR
J Clin Oncol 2020 Oct 1;38(28):3261-3272. Epub 2020 Jul 14 doi: 10.1200/JCO.19.02750. PMID: 32663119Free PMC Article
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Sep;24(5):235-251. doi: 10.1097/PAP.0000000000000162. PMID: 28777142Free PMC Article
The prognostic ease and difficulty of invasive breast carcinoma.
Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M, Dumeaux V, Hallett M
Cell Rep 2014 Oct 9;9(1):129-142. Epub 2014 Oct 2 doi: 10.1016/j.celrep.2014.08.073. PMID: 25284793
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Clinical prediction guides

Molecular Characterization of HER2-Low Invasive Breast Carcinoma by Quantitative RT-PCR Using Oncotype DX Assay.
Lin HK, Can T, Kahn A, Flannery CA, Hoag J, Akkunuri A, Bailey H, Baehner R, Pusztai L, Rozenblit M
Oncologist 2023 Oct 3;28(10):e973-e976. doi: 10.1093/oncolo/oyad249. PMID: 37656608Free PMC Article
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Nov;24(6):311-335. doi: 10.1097/PAP.0000000000000161. PMID: 28777143Free PMC Article
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Sep;24(5):235-251. doi: 10.1097/PAP.0000000000000162. PMID: 28777142Free PMC Article
The prognostic ease and difficulty of invasive breast carcinoma.
Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M, Dumeaux V, Hallett M
Cell Rep 2014 Oct 9;9(1):129-142. Epub 2014 Oct 2 doi: 10.1016/j.celrep.2014.08.073. PMID: 25284793

Recent systematic reviews

The "Forgotten" Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors.
Koufopoulos NI, Boutas I, Pouliakis A, Samaras MG, Kotanidis C, Kontogeorgi A, Dimas DT, Ieronimaki AI, Leventakou D, Spathis A, Zanelli M, Palicelli A, Zizzo M, Goutas D, Pateras IS, Panayiotides IG
Int J Mol Sci 2024 Aug 1;25(15) doi: 10.3390/ijms25158382. PMID: 39125951Free PMC Article
Clinicopathologic and Molecular Characteristics of and Diagnostic Dilemmas in Invasive Breast Carcinoma with Choriocarcinomatous Pattern apropos a New Case: A Literature Review with New Findings.
Jun SY, Yoon N, An S, Kang YJ, Park CS
Pathobiology 2022;89(6):359-369. Epub 2022 Mar 30 doi: 10.1159/000522621. PMID: 35354152Free PMC Article
Incidental axillary dose delivery to axillary lymph node levels I-III by different techniques of whole-breast irradiation: a systematic literature review.
Schmitt M, Pin Y, Pflumio C, Mathelin C, Pivot X, Noel G
Strahlenther Onkol 2021 Sep;197(9):820-828. Epub 2021 Jul 22 doi: 10.1007/s00066-021-01808-y. PMID: 34292348
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy.
van Wely BJ, Teerenstra S, Schinagl DA, Aufenacker TJ, de Wilt JH, Strobbe LJ
Br J Surg 2011 Mar;98(3):326-33. Epub 2010 Nov 30 doi: 10.1002/bjs.7360. PMID: 21254004

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...