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Complex febrile seizure

MedGen UID:
155493
•Concept ID:
C0751057
•
Disease or Syndrome
Synonyms: Complex febrile convulsion; complex febrile convulsions; Complex febrile seizures; Complex fever fit
SNOMED CT: Complex febrile seizure (433083002); Complex febrile convulsion (433083002)
 
HPO: HP:0011172

Definition

A febrile seizure that has any of the following features [from HPO]

Conditions with this feature

CATARACTS, SPASTIC PARAPARESIS, AND SPEECH DELAY
MedGen UID:
1778818
•Concept ID:
C5543440
•
Disease or Syndrome
Cataracts, spastic paraparesis, and speech delay (CSPSD) is an autosomal dominant disorder characterized by spastic paraparesis and bilateral congenital/juvenile cataracts. Speech delay is a common feature (Ferdinandusse et al., 2021).
See: Condition Record
CATARACTS, SPASTIC PARAPARESIS, AND SPEECH DELAY

Professional guidelines

PubMed

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415

Recent clinical studies

Etiology

Simple and complex febrile seizures: is there such a difference? Management and complications in an emergency department.
Rivas-García A, Ferrero-García-Loygorri C, Carrascón González-Pinto L, Mora-Capín AA, Lorente-Romero J, Vázquez-López P
Neurologia (Engl Ed) 2022 Jun;37(5):317-324. Epub 2021 May 27 doi: 10.1016/j.nrleng.2019.05.010. PMID: 35672118
Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration.
Kloc ML, Marchand DH, Holmes GL, Pressman RD, Barry JM
Epilepsy Behav 2022 Jan;126:108430. Epub 2021 Dec 10 doi: 10.1016/j.yebeh.2021.108430. PMID: 34902661Free PMC Article
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484

Diagnosis

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Simple and complex febrile seizures: is there such a difference? Management and complications in an emergency department.
Rivas-García A, Ferrero-García-Loygorri C, Carrascón González-Pinto L, Mora-Capín AA, Lorente-Romero J, Vázquez-López P
Neurologia (Engl Ed) 2022 Jun;37(5):317-324. Epub 2021 May 27 doi: 10.1016/j.nrleng.2019.05.010. PMID: 35672118
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Predictors of unprovoked seizure after febrile seizure: short-term outcomes.
Hwang G, Kang HS, Park SY, Han KH, Kim SH
Brain Dev 2015 Mar;37(3):315-21. Epub 2014 Jun 28 doi: 10.1016/j.braindev.2014.06.003. PMID: 24985020
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484

Therapy

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Simple and complex febrile seizures: is there such a difference? Management and complications in an emergency department.
Rivas-García A, Ferrero-García-Loygorri C, Carrascón González-Pinto L, Mora-Capín AA, Lorente-Romero J, Vázquez-López P
Neurologia (Engl Ed) 2022 Jun;37(5):317-324. Epub 2021 May 27 doi: 10.1016/j.nrleng.2019.05.010. PMID: 35672118
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484

Prognosis

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Severe Factor X Deficiency Presenting as Febrile Seizure in an Infant.
Garg M, Ramzan M, Kumawat A, Mittal J, Katewa S, Gupta P
J Pediatr Hematol Oncol 2020 Aug;42(6):e511-e512. doi: 10.1097/MPH.0000000000001453. PMID: 30870385
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Predictors of unprovoked seizure after febrile seizure: short-term outcomes.
Hwang G, Kang HS, Park SY, Han KH, Kim SH
Brain Dev 2015 Mar;37(3):315-21. Epub 2014 Jun 28 doi: 10.1016/j.braindev.2014.06.003. PMID: 24985020
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484

Clinical prediction guides

Children With Complex Febrile Seizures: Is Hospital Admission Necessary?
Kannikeswaran N, Sivaswamy L, Farooqi A, Sethuraman U
Clin Pediatr (Phila) 2021 Jul;60(8):363-369. Epub 2021 May 20 doi: 10.1177/00099228211017702. PMID: 34014115
Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age.
Sheppard E, Lalancette E, Thébault-Dagher F, Lafontaine MP, Knoth IS, Gravel J, Lippé S
Epileptic Disord 2021 Apr 1;23(2):325-336. doi: 10.1684/epd.2021.1260. PMID: 33814363
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Utility of initial EEG in first complex febrile seizure.
Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T
Epilepsy Behav 2015 Nov;52(Pt A):200-4. Epub 2015 Oct 6 doi: 10.1016/j.yebeh.2015.09.003. PMID: 26448592
Predictors of unprovoked seizure after febrile seizure: short-term outcomes.
Hwang G, Kang HS, Park SY, Han KH, Kim SH
Brain Dev 2015 Mar;37(3):315-21. Epub 2014 Jun 28 doi: 10.1016/j.braindev.2014.06.003. PMID: 24985020

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