U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal hemoglobin

MedGen UID:
776552
•Concept ID:
C0349705
•
Finding
Synonyms: Abnormal haemoglobin; Abnormal Hb
 
HPO: HP:0011902

Definition

Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. [from HPO]

Professional guidelines

PubMed

Understanding Sickle cell disease: Causes, symptoms, and treatment options.
Elendu C, Amaechi DC, Alakwe-Ojimba CE, Elendu TC, Elendu RC, Ayabazu CP, Aina TO, Aborisade O, Adenikinju JS
Medicine (Baltimore) 2023 Sep 22;102(38):e35237. doi: 10.1097/MD.0000000000035237. PMID: 37746969Free PMC Article
Sickle Cell Disease and Thromboembolism: New Insights on the Pathophysiology, Diagnosis, and Treatment.
Dobie G
Clin Lab 2023 Jul 1;69(7) doi: 10.7754/Clin.Lab.2023.221006. PMID: 37436376
Artemisinin derivative-containing therapies and abnormal hemoglobin: Do we need to adapt the treatment?
Gbessi EA, Toure OA, Gnondjui A, Koui TS, Coulibaly B, Ako BA, Tiacoh NL, Assi SB, Sanogo I, Sokouri DP, Jambou R
Parasite 2021;28:67. Epub 2021 Sep 27 doi: 10.1051/parasite/2021063. PMID: 34569928Free PMC Article

Recent clinical studies

Etiology

Treating Sickle Cell Disease: Gene Therapy Approaches.
Cavazzana M, Corsia A, Brusson M, Miccio A, Semeraro M
Annu Rev Pharmacol Toxicol 2025 Jan;65(1):397-413. Epub 2024 Dec 17 doi: 10.1146/annurev-pharmtox-022124-022000. PMID: 39259977
Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease.
Nader E, Romana M, Connes P
Front Immunol 2020;11:454. Epub 2020 Mar 13 doi: 10.3389/fimmu.2020.00454. PMID: 32231672Free PMC Article
Orthopaedic Manifestations of Sickle Cell Disease.
Vanderhave KL, Perkins CA, Scannell B, Brighton BK
J Am Acad Orthop Surg 2018 Feb 1;26(3):94-101. doi: 10.5435/JAAOS-D-16-00255. PMID: 29309293
Prenatal cellular transplantation.
Albanese CT, Harrison MR
Semin Pediatr Surg 1999 Aug;8(3):101-8. doi: 10.1016/s1055-8586(99)70010-7. PMID: 10461322

Diagnosis

Understanding Sickle cell disease: Causes, symptoms, and treatment options.
Elendu C, Amaechi DC, Alakwe-Ojimba CE, Elendu TC, Elendu RC, Ayabazu CP, Aina TO, Aborisade O, Adenikinju JS
Medicine (Baltimore) 2023 Sep 22;102(38):e35237. doi: 10.1097/MD.0000000000035237. PMID: 37746969Free PMC Article
Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease.
Nader E, Romana M, Connes P
Front Immunol 2020;11:454. Epub 2020 Mar 13 doi: 10.3389/fimmu.2020.00454. PMID: 32231672Free PMC Article
Sickle cell disease in childhood: from newborn screening through transition to adult medical care.
Quinn CT
Pediatr Clin North Am 2013 Dec;60(6):1363-81. doi: 10.1016/j.pcl.2013.09.006. PMID: 24237976Free PMC Article
Prenatal cellular transplantation.
Albanese CT, Harrison MR
Semin Pediatr Surg 1999 Aug;8(3):101-8. doi: 10.1016/s1055-8586(99)70010-7. PMID: 10461322

Therapy

Current and Future Therapeutics for Treating Patients with Sickle Cell Disease.
Barak M, Hu C, Matthews A, Fortenberry YM
Cells 2024 May 16;13(10) doi: 10.3390/cells13100848. PMID: 38786070Free PMC Article
A Case That Will Take Your Breath Away: Acquired Methemoglobinemia Related to Trimethoprim-Sulfamethoxazole and Phenazopyridine Ingestion for Treatment of Urinary Tract Infection.
Sharma V, Robertson K, Domagalski J
WMJ 2023 Sep;122(4):287-289. PMID: 37768772
The Role of miRNAs as Therapeutic Tools in Sickle Cell Disease.
Cyrus C
Medicina (Kaunas) 2021 Oct 14;57(10) doi: 10.3390/medicina57101106. PMID: 34684143Free PMC Article
Novel Sickle Cell Disease Therapies: Targeting Pathways Downstream of Sickling.
Morrone K, Mitchell WB, Manwani D
Semin Hematol 2018 Apr;55(2):68-75. Epub 2018 Apr 20 doi: 10.1053/j.seminhematol.2018.04.007. PMID: 30616808
Inflammatory targets of therapy in sickle cell disease.
Owusu-Ansah A, Ihunnah CA, Walker AL, Ofori-Acquah SF
Transl Res 2016 Jan;167(1):281-97. Epub 2015 Jul 11 doi: 10.1016/j.trsl.2015.07.001. PMID: 26226206Free PMC Article

Prognosis

Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
Coinheritance of Hb D-Punjab and β-thalassemia: diagnosis and implications in prenatal diagnosis.
Das S, Mashon RS
Hemoglobin 2015;39(2):138-40. Epub 2015 Feb 10 doi: 10.3109/03630269.2015.1004335. PMID: 25666204
Sickle cell disease in childhood: from newborn screening through transition to adult medical care.
Quinn CT
Pediatr Clin North Am 2013 Dec;60(6):1363-81. doi: 10.1016/j.pcl.2013.09.006. PMID: 24237976Free PMC Article
Epidemiology of sickle cell disease in Saudi Arabia.
Jastaniah W
Ann Saudi Med 2011 May-Jun;31(3):289-93. doi: 10.4103/0256-4947.81540. PMID: 21623060Free PMC Article
Sickle cell anemia.
Lonergan GJ, Cline DB, Abbondanzo SL
Radiographics 2001 Jul-Aug;21(4):971-94. doi: 10.1148/radiographics.21.4.g01jl23971. PMID: 11452073

Clinical prediction guides

How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life.
Merlet AN, Chatel B, Hourdé C, Ravelojaona M, Bendahan D, Féasson L, Messonnier LA
Med Sci Sports Exerc 2019 Jan;51(1):4-11. doi: 10.1249/MSS.0000000000001757. PMID: 30095751
The 'hot-spot' of Hb E [beta26(B8)Glu-->Lys] in Southeast Asia: beta-globin anomalies in the Lao Theung population of southern Laos.
Flatz G, Sanguansermsri T, Sengchanh S, Horst D, Horst J
Hemoglobin 2004 Aug;28(3):197-204. doi: 10.1081/hem-120040334. PMID: 15481886
Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria.
Liu JS, Molchanova TP, Gu LH, Wilson JB, Hopmeier P, Schnedl W, Balaun E, Krejs GJ, Huisman TH
Hemoglobin 1992;16(6):493-501. doi: 10.3109/03630269208993117. PMID: 1487420
Beta-thalassemia in Turkey.
Oner R, Altay C, Gurgey A, Aksoy M, Kilinç Y, Stoming TA, Reese AL, Kutlar A, Kutlar F, Huisman TH
Hemoglobin 1990;14(1):1-13. doi: 10.3109/03630269009002250. PMID: 2200760
Thermal stability and cross-linking of Hb New York [beta 113(G15)Val----Glu].
Yang T, Olsen KW
Hemoglobin 1989;13(2):147-56. doi: 10.3109/03630268908998064. PMID: 2737909

Recent systematic reviews

Hydroxyurea can be used in children with sickle cell disease and cerebral vasculopathy for the prevention of chronic complications? A meta-analysis.
Núñez RM, Figueroa CAP, García-Perdomo HA
J Child Health Care 2020 Mar;24(1):64-77. Epub 2019 Jan 3 doi: 10.1177/1367493518814922. PMID: 30606035
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2018 Nov 16;11(11):CD007652. doi: 10.1002/14651858.CD007652.pub6. PMID: 30480767Free PMC Article
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2016 Nov 14;11:CD007652. doi: 10.1002/14651858.CD007652.pub5. PMID: 27841932
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2014 Oct 10;(10):CD007652. doi: 10.1002/14651858.CD007652.pub4. PMID: 25300171
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2012 Nov 14;11:CD007652. doi: 10.1002/14651858.CD007652.pub3. PMID: 23152248

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...