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Thrombotic stroke

MedGen UID:
537131
•Concept ID:
C0242129
•
Disease or Syndrome
Synonyms: Stroke, Thrombotic; Thrombotic Stroke; Thrombotic Strokes
SNOMED CT: Thrombotic stroke (371040005)

Definition

A type of ischemic stroke resulting from obstruction due to a BLOOD CLOT formed within in a CEREBRAL ARTERY often associated with ATHEROSCLEROSIS. A stroke due to a blood clot in a cerebral vein is a venous infarction (see VENOUS INFARCTION, BRAIN). [from MeSH]

Professional guidelines

PubMed

Neonatal Antiepileptic Medication Treatment Patterns: A Decade of Change.
Le VT, Abdi HH, Sánchez PJ, Yossef L, Reagan PB, Slaughter LA, Firestine A, Slaughter JL
Am J Perinatol 2021 Apr;38(5):469-476. Epub 2019 Oct 10 doi: 10.1055/s-0039-1698457. PMID: 31600794Free PMC Article
The management of stroke in antiphospholipid syndrome.
Panichpisal K, Rozner E, Levine SR
Curr Rheumatol Rep 2012 Feb;14(1):99-106. doi: 10.1007/s11926-011-0223-5. PMID: 22109663
Management of patients with carotid stenosis.
De Fabritiis A, Conti E, Coccheri S
Pathophysiol Haemost Thromb 2002 Sep-Dec;32(5-6):381-5. doi: 10.1159/000073605. PMID: 13679681

Curated

UK NICE Guideline (NG236), Stroke rehabilitation in adults, 2023

UK NICE Guideline NG128, Stroke and transient ischaemic attack in over 16s: diagnosis and initial management, 2019

Recent clinical studies

Etiology

Neurological Sequelae of COVID-19.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ
J Integr Neurosci 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077. PMID: 35633158
Arterial and venous thrombotic stroke after ChAdOx1 nCoV-19 vaccine.
Wills A, Swallow G, Kirkman MA, Rajan K, Subramanian G
Clin Med (Lond) 2022 Mar;22(2):184-186. doi: 10.7861/clinmed.2021-0321. PMID: 35304381Free PMC Article
Perioperative stroke.
Vlisides P, Mashour GA
Can J Anaesth 2016 Feb;63(2):193-204. Epub 2015 Sep 21 doi: 10.1007/s12630-015-0494-9. PMID: 26391795Free PMC Article
Hyperhomocysteinemia and venous thrombosis.
Gatt A, Makris M
Semin Hematol 2007 Apr;44(2):70-6. doi: 10.1053/j.seminhematol.2007.01.002. PMID: 17433898
Hypertension and vascular disease.
Doyle AE
Am J Hypertens 1991 Feb;4(2 Pt 2):103S-106S. doi: 10.1093/ajh/4.2.103s. PMID: 2021454

Diagnosis

Cardiopulmonary Emergencies in Older Adults.
Theophanous R, Huang W, Ragsdale L
Emerg Med Clin North Am 2021 May;39(2):323-338. doi: 10.1016/j.emc.2021.01.010. PMID: 33863462
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
Pretorius E, Kell DB
Integr Biol (Camb) 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k. PMID: 24714688
De novo infantile primary antiphospholipid antibody syndrome.
Alshekaili J, Reynolds G, Cook MC
Lupus 2010 Nov;19(13):1565-8. Epub 2010 Jul 27 doi: 10.1177/0961203310375263. PMID: 20663842
C-reactive protein and risks of future myocardial infarction and thrombotic stroke.
Ridker PM
Eur Heart J 1998 Jan;19(1):1-3. doi: 10.1053/euhj.1997.0604. PMID: 9503166
Future role of thrombolytic therapy in emergency medicine.
Bresler MJ
Ann Emerg Med 1989 Dec;18(12):1331-8. doi: 10.1016/s0196-0644(89)80271-9. PMID: 2511790

Therapy

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
Ischemic Stroke.
Feske SK
Am J Med 2021 Dec;134(12):1457-1464. Epub 2021 Aug 27 doi: 10.1016/j.amjmed.2021.07.027. PMID: 34454905
Cardiopulmonary Emergencies in Older Adults.
Theophanous R, Huang W, Ragsdale L
Emerg Med Clin North Am 2021 May;39(2):323-338. doi: 10.1016/j.emc.2021.01.010. PMID: 33863462
Perioperative stroke.
Vlisides P, Mashour GA
Can J Anaesth 2016 Feb;63(2):193-204. Epub 2015 Sep 21 doi: 10.1007/s12630-015-0494-9. PMID: 26391795Free PMC Article
Argatroban in thrombotic stroke.
LaMonte MP
Pathophysiol Haemost Thromb 2002;32 Suppl 3:39-45. doi: 10.1159/000069108. PMID: 12811011

Prognosis

The feasibility of dual-energy CT to predict the probability of symptomatic intracerebral haemorrhage after successful mechanical thrombectomy.
Ma C, Hui Q, Gao X, Xu D, Tang B, Pen M, Lui S, Chen X
Clin Radiol 2021 Apr;76(4):316.e9-316.e18. Epub 2021 Jan 26 doi: 10.1016/j.crad.2020.12.013. PMID: 33509606
Stroke and Etonogestrel/Ethinyl Estradiol Ring (NuvaRing): Clinical, Radiological, and Prognostic Features.
Selvan P, Piran P, Balucani C, Tark B, Adler Z, Levine SR
J Stroke Cerebrovasc Dis 2017 Mar;26(3):608-617. Epub 2016 Dec 29 doi: 10.1016/j.jstrokecerebrovasdis.2016.11.111. PMID: 28041897
Lipoprotein (a) and stroke.
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article
C-reactive protein and risks of future myocardial infarction and thrombotic stroke.
Ridker PM
Eur Heart J 1998 Jan;19(1):1-3. doi: 10.1053/euhj.1997.0604. PMID: 9503166
Follow-up study of pseudoephedrine users.
Porta M, Jick H, Habakangas JA
Ann Allergy 1986 Nov;57(5):340-2. PMID: 3777533

Clinical prediction guides

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
Clinical safety and outcome of recombinant tissue plasminogen activator in patients with stroke attributable to small artery occlusion: A protocol for systematic review and meta-analysis.
Ni LY, Tang JY
Medicine (Baltimore) 2021 Jun 25;100(25):e26453. doi: 10.1097/MD.0000000000026453. PMID: 34160442Free PMC Article
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
Pretorius E, Kell DB
Integr Biol (Camb) 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k. PMID: 24714688
Lipoprotein (a) and stroke.
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article
C-reactive protein and risks of future myocardial infarction and thrombotic stroke.
Ridker PM
Eur Heart J 1998 Jan;19(1):1-3. doi: 10.1053/euhj.1997.0604. PMID: 9503166

Recent systematic reviews

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
Tenecteplase for thrombolysis in stroke patients: Systematic review with meta-analysis.
Oliveira M, Fidalgo M, Fontão L, Antão J, Marques S, Afreixo V, Gregório T
Am J Emerg Med 2021 Apr;42:31-37. Epub 2020 Dec 24 doi: 10.1016/j.ajem.2020.12.026. PMID: 33440328
Atrial fibrillation as a prognostic indicator of myocardial infarction and cardiovascular death: a systematic review and meta-analysis.
He W, Chu Y
Sci Rep 2017 Jun 13;7(1):3360. doi: 10.1038/s41598-017-03653-5. PMID: 28611377Free PMC Article

Supplemental Content

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    Clinical resources

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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline (NG236), Stroke rehabilitation in adults, 2023
    • NICE, 2019
      UK NICE Guideline NG128, Stroke and transient ischaemic attack in over 16s: diagnosis and initial management, 2019

    Consumer resources

    Reviews

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