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Hemolytic disease of fetus OR newborn due to RhD isoimmunization

MedGen UID:
472905
•Concept ID:
C0158962
•
Disease or Syndrome
Synonyms: Anemia due to Rh isoimmunization; Erythroblastosis fetalis due to Rh isoimmunization; Hemolytic disease - Rh; Hemolytic disease due to Rh isoimmunization; Hemolytic disease due to rhesus isoimmunization; Hemolytic disease of fetus OR newborn due to Rh isoimmunization; Jaundice due to Rh isoimmunization of the newborn; Rh HDN - Rh hemolytic disease of the newborn; Rh hemolytic disease of the newborn; Rh isoimmunization of the newborn; Rhesus isoimmunization of the newborn
SNOMED CT: Rh hemolytic disease of the newborn (86986002); Rh isoimmunization of the newborn (86986002); Anemia due to Rh isoimmunization (86986002); Hemolytic disease due to Rh isoimmunization (86986002); Rhesus isoimmunization of the newborn (86986002); Erythroblastosis fetalis due to Rh isoimmunization (86986002); Jaundice due to Rh isoimmunization of the newborn (86986002); Hemolytic disease of fetus OR newborn due to Rh isoimmunization (86986002); Hemolytic disease of fetus OR newborn due to RhD isoimmunization (86986002); Hemolytic disease - Rh (86986002); Hemolytic disease due to rhesus isoimmunization (86986002); Rh HDN - Rh hemolytic disease of the newborn (86986002)

Professional guidelines

PubMed

Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.
Obstet Gynecol 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673

Recent clinical studies

Etiology

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn.
Delaney M, Matthews DC
Hematology Am Soc Hematol Educ Program 2015;2015:146-51. doi: 10.1182/asheducation-2015.1.146. PMID: 26637714
Hemolytic disease.
Freda V
Clin Obstet Gynecol 1973 Mar;16(1):72-102. doi: 10.1097/00003081-197303000-00005. PMID: 4196840

Diagnosis

Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.
Obstet Gynecol 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Therapy

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
New developments in fetal and neonatal alloimmune thrombocytopenia.
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Transfusion-related red blood cell alloantibodies: induction and consequences.
Tormey CA, Hendrickson JE
Blood 2019 Apr 25;133(17):1821-1830. Epub 2019 Feb 26 doi: 10.1182/blood-2018-08-833962. PMID: 30808636Free PMC Article
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673

Prognosis

Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations.
Hendrickson JE, Delaney M
Transfus Med Rev 2016 Oct;30(4):159-64. Epub 2016 May 26 doi: 10.1016/j.tmrv.2016.05.008. PMID: 27397673
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Fatal hemolytic disease of the fetus and newborn possibly due to anti-Jr.
Arriaga F, Gomez I, Linares MD, Gascon A, Carpio N, Perales A
Transfusion 2009 Apr;49(4):813. doi: 10.1111/j.1537-2995.2008.02087.x. PMID: 19335378
Treatment options for the fetus with alloimmune hemolytic disease.
Bowman JM
Transfus Med Rev 1990 Jul;4(3):191-207. doi: 10.1016/s0887-7963(90)70265-9. PMID: 2134630
Immunoglobulins in haemolytic disease of the newborn.
McKay E, Thom H
Biol Neonate 1973;23(3):214-22. doi: 10.1159/000240603. PMID: 4204178

Clinical prediction guides

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D, Lopriore E
BMC Pregnancy Childbirth 2023 Oct 18;23(1):738. doi: 10.1186/s12884-023-06061-y. PMID: 37853331Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Patient experience and burden of haemolytic disease of the foetus and newborn: a systematic review.
Maurice P, McCallion J, Fitzgibbon M, Barthelmes JN, Karmous W, Hardy EJ, Mitchell SA, Mitchell CR, Lee J, Noel W, Borsi A, Jouannic JM
BMC Pregnancy Childbirth 2025 Feb 4;25(1):114. doi: 10.1186/s12884-025-07208-9. PMID: 39905388Free PMC Article
Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis.
Mustafa HJ, Sambatur EV, Pagani G, D'Antonio F, Maisonneuve E, Maurice P, Zwiers C, Verweij JEJT, Flood A, Shamshirsaz AA, Jouannic JM, Khalil A
Am J Obstet Gynecol 2024 Oct;231(4):417-429.e21. Epub 2024 Apr 7 doi: 10.1016/j.ajog.2024.03.044. PMID: 38588966
Misclassification of RhD variants among pregnant women: a systematic review.
Owaidah AY, Yamani LZ
J Med Life 2023 Jul;16(7):981-989. doi: 10.25122/jml-2023-0004. PMID: 37900088Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Non-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Alshehri AA, Jackson DE
Transfus Med Rev 2021 Apr;35(2):85-94. Epub 2021 Mar 1 doi: 10.1016/j.tmrv.2021.02.001. PMID: 33781630

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