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Salivary gland neoplasm

MedGen UID:
20641
•Concept ID:
C0036095
•
Neoplastic Process
Synonym: Tumor of salivary gland
SNOMED CT: Tumor of salivary gland (235132004); Neoplasm of salivary gland (235132004)
 
HPO: HP:0100684
Monarch Initiative: MONDO:0021357

Definition

A tumor (abnormal growth of tissue) of a salivary gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland neoplasm

Conditions with this feature

Pleomorphic adenoma of salivary gland
MedGen UID:
275400
•Concept ID:
C1519176
•
Neoplastic Process
A rare tumor of salivary glands characterized by a benign, well-circumscribed, slow-growing, painless mass most commonly occurring in the parotid gland (but also the palate, submandibular gland, or nasal septal mucosa), histopathologically composed of epithelial and myoepithelial / stromal components. Possible signs and symptoms depend on the location of the tumor and include facial nerve weakness, mild dysphagia, or unilateral nasal obstruction. Recurrence rates are low, although tumor rupture and spillage have been reported. Malignant transformation may occur in a small percentage of cases.
See: Condition Record
Pleomorphic adenoma of salivary gland

Professional guidelines

PubMed

Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing.
Alamri AM, Liu X, Blancato JK, Haddad BR, Wang W, Zhong X, Choudhary S, Krawczyk E, Kallakury BV, Davidson BJ, Furth PA
Dis Model Mech 2018 Jan 29;11(1) doi: 10.1242/dmm.031716. PMID: 29419396Free PMC Article
Classification and differential diagnosis of clear and basal cell tumors of the salivary glands.
Seifert G
Semin Diagn Pathol 1996 May;13(2):95-103. PMID: 8734415

Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
An atypically located pleomorphic adenoma: Radiological and pathological correlation.
Teh J, Dessauvagie B, Kessell M, Dissanayake D, Wylie EJ
J Med Imaging Radiat Oncol 2022 Feb;66(1):105-106. Epub 2021 Mar 25 doi: 10.1111/1754-9485.13178. PMID: 33768733
Sebaceous Lymphadenoma: Radiology-Pathology Correlation.
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland.
Lubin D, Song S, Zafar HM, Baloch Z
Diagn Cytopathol 2019 Jun;47(6):617-636. Epub 2019 Mar 26 doi: 10.1002/dc.24175. PMID: 30912629
Warthin's tumor and cigarette smoking.
Vories AA, Ramirez SG
South Med J 1997 Apr;90(4):416-8. doi: 10.1097/00007611-199704000-00011. PMID: 9114834

Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
Imaging of Major Salivary Gland Lesions and Disease.
Friedman E, Cai Y, Chen B
Oral Maxillofac Surg Clin North Am 2023 Aug;35(3):435-449. Epub 2023 Apr 7 doi: 10.1016/j.coms.2023.02.007. PMID: 37032181
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Mucoepidermoid carcinoma. An update and review of the literature.
Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266

Therapy

CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target.
Mayer M, Nachtsheim L, Hoffmann F, von Eggeling F, Guntinas-Lichius O, Prinz J, Klußmann JP, Quaas A, Arolt C, Wolber P
Int J Mol Sci 2022 Aug 12;23(16) doi: 10.3390/ijms23169037. PMID: 36012301Free PMC Article
Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab.
Lajara S, Landau M
Diagn Cytopathol 2021 Sep;49(9):E370-E373. Epub 2021 Jun 26 doi: 10.1002/dc.24817. PMID: 34174024
Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing.
Alamri AM, Liu X, Blancato JK, Haddad BR, Wang W, Zhong X, Choudhary S, Krawczyk E, Kallakury BV, Davidson BJ, Furth PA
Dis Model Mech 2018 Jan 29;11(1) doi: 10.1242/dmm.031716. PMID: 29419396Free PMC Article
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481
Warthin's tumor and cigarette smoking.
Vories AA, Ramirez SG
South Med J 1997 Apr;90(4):416-8. doi: 10.1097/00007611-199704000-00011. PMID: 9114834

Prognosis

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389
Epithelial-myoepithelial carcinoma--review of clinicopathological and immunohistochemical features.
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941

Clinical prediction guides

Application of the Milan System for Reporting Salivary Gland Cytopathology: A systematic review and meta-analysis.
Wang Z, Zhao H, Guo H, An C
Cancer Cytopathol 2022 Nov;130(11):849-859. Epub 2022 May 30 doi: 10.1002/cncy.22604. PMID: 35637572Free PMC Article
Salivary gland neoplasms with basaloid features in the era of the Milan system for reporting salivary gland cytology: Classification and interobserver agreement.
Layfield LJ, Esebua M, Pantanowitz L, Maleki Z, Vazmitsel M, Baloch Z, Cantley RL, Schmidt R
Diagn Cytopathol 2022 Jul;50(7):341-349. Epub 2022 Apr 23 doi: 10.1002/dc.24962. PMID: 35460214
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389
Margins for Benign Salivary Gland Neoplasms of the Head and Neck.
Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532
Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach.
Nakashima T, Yasumatsu R, Yamauchi M, Toh S, Nakano T, Yamamoto H, Komune S
J Laryngol Otol 2015 Mar;129 Suppl 2:S95-7. doi: 10.1017/S0022215114002485. PMID: 25706172

Recent systematic reviews

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Application of the Milan System for Reporting Salivary Gland Cytopathology: A systematic review and meta-analysis.
Wang Z, Zhao H, Guo H, An C
Cancer Cytopathol 2022 Nov;130(11):849-859. Epub 2022 May 30 doi: 10.1002/cncy.22604. PMID: 35637572Free PMC Article
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Comparison of core needle biopsy and fine-needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta-analysis.
Cho J, Kim J, Lee JS, Chee CG, Kim Y, Choi SI
Head Neck 2020 Oct;42(10):3041-3050. Epub 2020 Jul 16 doi: 10.1002/hed.26377. PMID: 32671867
Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review.
Munhoz L, Ramos EADA, Im DC, Hisatomi M, Yanagi Y, Asaumi J, Arita ES
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Sep;128(3):280-310. Epub 2019 Mar 1 doi: 10.1016/j.oooo.2019.02.020. PMID: 31029591

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