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Morbid obesity

MedGen UID:
18128
•Concept ID:
C0028756
•
Disease or Syndrome
Synonym: OBESITY, SEVERE
SNOMED CT: Severe obesity (83911000119104); Morbid obesity (238136002)
 
Monarch Initiative: MONDO:0005139
OMIM®: 601487; 602044

Definition

An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorbid obesity

Professional guidelines

PubMed

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics.
Glueck CJ, Goldenberg N
Metabolism 2019 Mar;92:108-120. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.002. PMID: 30445140
Consensus document. Management of non-alcoholic fatty liver disease (NAFLD). Clinical practice guideline.
Aller R, Fernández-Rodríguez C, Lo Iacono O, Bañares R, Abad J, Carrión JA, García-Monzón C, Caballería J, Berenguer M, Rodríguez-Perálvarez M, Miranda JL, Vilar-Gómez E, Crespo J, García-Cortés M, Reig M, Navarro JM, Gallego R, Genescà J, Arias-Loste MT, Pareja MJ, Albillos A, Muntané J, Jorquera F, Solà E, Hernández-Guerra M, Rojo MÁ, Salmerón J, Caballería L, Diago M, Molina E, Bataller R, Romero-Gómez M
Gastroenterol Hepatol 2018 May;41(5):328-349. Epub 2018 Apr 7 doi: 10.1016/j.gastrohep.2017.12.003. PMID: 29631866
European Guidelines for Obesity Management in Adults.
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article

Recent clinical studies

Etiology

Anesthesia for Morbidly Obese Patients.
Hardt K, Wappler F
Dtsch Arztebl Int 2023 Nov 17;120(46):779-785. doi: 10.3238/arztebl.m2023.0216. PMID: 37874129Free PMC Article
But Why Weight: Understanding the Implications of Obesity in Kidney Transplant.
Vranic G, Cooper M
Semin Nephrol 2021 Jul;41(4):380-391. doi: 10.1016/j.semnephrol.2021.06.009. PMID: 34715967
The use of anticoagulants in morbidly obese patients.
Domienik-Karłowicz J, Pruszczyk P
Cardiol J 2016;23(1):12-6. Epub 2015 Sep 28 doi: 10.5603/CJ.a2015.0054. PMID: 26412600
Laparoscopic sleeve gastrectomy and gastroesophageal reflux.
Stenard F, Iannelli A
World J Gastroenterol 2015 Sep 28;21(36):10348-57. doi: 10.3748/wjg.v21.i36.10348. PMID: 26420961Free PMC Article
Surgical treatment of morbid obesity.
Crookes PF
Annu Rev Med 2006;57:243-64. doi: 10.1146/annurev.med.56.062904.144928. PMID: 16409148

Diagnosis

Recurrent Angioedema.
Ledford DK, Craig TJ
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1427-1429. doi: 10.1016/j.jaip.2018.05.009. PMID: 30033921
Understanding the role of psychopathology in bariatric surgery outcomes.
Marek RJ, Ben-Porath YS, Heinberg LJ
Obes Rev 2016 Feb;17(2):126-41. doi: 10.1111/obr.12356. PMID: 26783067
Laparoscopic sleeve gastrectomy and gastroesophageal reflux.
Stenard F, Iannelli A
World J Gastroenterol 2015 Sep 28;21(36):10348-57. doi: 10.3748/wjg.v21.i36.10348. PMID: 26420961Free PMC Article
Nonalcoholic fatty liver disease and bariatric surgery in adolescents.
Holterman A, Gurria J, Tanpure S, DiSomma N
Semin Pediatr Surg 2014 Feb;23(1):49-57. Epub 2013 Oct 31 doi: 10.1053/j.sempedsurg.2013.10.016. PMID: 24491369
Treating morbid obesity.
Pettit E
RN 2009 Feb;72(2):30-4; quiz 35. PMID: 19283941

Therapy

Naltrexone/bupropion for obesity.
Drug Ther Bull 2017 Nov;55(11):126-129. doi: 10.1136/dtb.2017.11.0550. PMID: 29117992
Interventions for treating obesity in children.
De Miguel-Etayo P, Bueno G, Garagorri JM, Moreno LA
World Rev Nutr Diet 2013;108:98-106. Epub 2013 Sep 6 doi: 10.1159/000351493. PMID: 24029793
Pharmacology and obesity.
Lemmens HJ, Ingrande J
Int Anesthesiol Clin 2013 Summer;51(3):52-66. doi: 10.1097/AIA.0b013e31829a4d56. PMID: 23797645
Bariatric surgical outcomes.
Ali MR, Fuller WD, Choi MP, Wolfe BM
Surg Clin North Am 2005 Aug;85(4):835-52, vii. doi: 10.1016/j.suc.2005.03.005. PMID: 16061089
Minimally invasive surgery.
Robinson TN, Stiegmann GV
Endoscopy 2004 Jan;36(1):48-51. doi: 10.1055/s-2004-814113. PMID: 14722855

Prognosis

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Current status of gastroesophageal reflux disease after sleeve gastrectomy: Still a long way to go.
Tian P, Fu J, Liu Y, Bian S, Li M, Zhang M, Liu J, Jin L, Zhang Z, Zhang P
Biosci Trends 2021 Nov 21;15(5):305-312. Epub 2021 Aug 10 doi: 10.5582/bst.2021.01288. PMID: 34373428
Complications of obesity.
Kinlen D, Cody D, O'Shea D
QJM 2018 Jul 1;111(7):437-443. doi: 10.1093/qjmed/hcx152. PMID: 29025162
Obesity and cancer: at the crossroads of cellular metabolism and proliferation.
O'Rourke RW
Surg Obes Relat Dis 2014 Nov-Dec;10(6):1208-19. Epub 2014 Aug 27 doi: 10.1016/j.soard.2014.08.012. PMID: 25264328Free PMC Article
NAFLD, obesity, and bariatric surgery.
Angulo P
Gastroenterology 2006 May;130(6):1848-52. doi: 10.1053/j.gastro.2006.03.041. PMID: 16697746

Clinical prediction guides

Impact of Bariatric Surgery on Female Sexual Function in Obese Patients: a Meta-Analysis.
Gao Z, Liang Y, Deng W, Qiu P, Li M, Zhou Z
Obes Surg 2020 Jan;30(1):352-364. doi: 10.1007/s11695-019-04240-5. PMID: 31664652
Sleeve Gastrectomy and Diabetes: Is Cure Possible?
Andalib A, Aminian A
Adv Surg 2017 Sep;51(1):29-40. Epub 2017 Jun 2 doi: 10.1016/j.yasu.2017.03.003. PMID: 28797344
Understanding the role of psychopathology in bariatric surgery outcomes.
Marek RJ, Ben-Porath YS, Heinberg LJ
Obes Rev 2016 Feb;17(2):126-41. doi: 10.1111/obr.12356. PMID: 26783067
Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity.
Cole TJ, Lobstein T
Pediatr Obes 2012 Aug;7(4):284-94. Epub 2012 Jun 19 doi: 10.1111/j.2047-6310.2012.00064.x. PMID: 22715120
The electrocardiogram in morbid obesity.
Alpert MA, Terry BE, Cohen MV, Fan TM, Painter JA, Massey CV
Am J Cardiol 2000 Apr 1;85(7):908-10, A10. doi: 10.1016/s0002-9149(99)00894-2. PMID: 10758940

Recent systematic reviews

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Plant-Based Diets and Cancer Prognosis: a Review of Recent Research.
Hardt L, Mahamat-Saleh Y, Aune D, Schlesinger S
Curr Nutr Rep 2022 Dec;11(4):695-716. Epub 2022 Sep 23 doi: 10.1007/s13668-022-00440-1. PMID: 36138327Free PMC Article
Treatment Options for Weight Regain or Insufficient Weight Loss After Sleeve Gastrectomy: a Systematic Review and Meta-analysis.
Franken RJ, Sluiter NR, Franken J, de Vries R, Souverein D, Gerdes VEA, de Brauw M
Obes Surg 2022 Jun;32(6):2035-2046. Epub 2022 Apr 2 doi: 10.1007/s11695-022-06020-0. PMID: 35366738
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Physical exercise and morbid obesity: a systematic review.
Fonseca-Junior SJ, Sá CG, Rodrigues PA, Oliveira AJ, Fernandes-Filho J
Arq Bras Cir Dig 2013;26 Suppl 1:67-73. doi: 10.1590/s0102-67202013000600015. PMID: 24463903

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