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MISSED ABORTION

MedGen UID:
1260
•Concept ID:
C0000814
•
Disease or Syndrome
Synonyms: Abortion, Missed; Abortions, Missed; Missed Abortion; Missed Abortions
SNOMED CT: MA - Missed abortion (16607004); Silent miscarriage (16607004); Missed miscarriage (16607004); Missed abortion (16607004)

Definition

Retention in uterus of an abortus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • MISSED ABORTION

Professional guidelines

PubMed

Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Medical management of missed abortion: a randomized clinical trial.
Wagaarachchi P, Ashok P, Templeton A
Obstet Gynecol 2002 Aug;100(2):383. PMID: 12151175
The management of missed abortion.
Ratten GJ
Aust N Z J Obstet Gynaecol 1970 May;10(2):115-8. doi: 10.1111/j.1479-828x.1970.tb00414.x. PMID: 5274333

Recent clinical studies

Etiology

Medical treatment of miscarriage using misoprostol-a retrospective study.
Meister L, Künnemann I, Fettke F, Lux A, Ignatov A
Arch Gynecol Obstet 2024 Oct;310(4):2115-2121. Epub 2024 Aug 13 doi: 10.1007/s00404-024-07628-6. PMID: 39136729Free PMC Article
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Thyrotoxicosis and pregnancy.
Perros P
PLoS Med 2005 Dec;2(12):e370. Epub 2005 Dec 27 doi: 10.1371/journal.pmed.0020370. PMID: 16363909Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Diagnosis

Biochemical markers for prediction of the first half pregnancy losses: a review.
Kuspanova M, Gaiday A, Dzhardemaliyeva N, Tuganbayev M, Gorobeiko M, Dinets A, Bermagambetova S, Amirbekova Z, Oraltayeva G, Omertayeva D, Tussupkaliyev A
Rev Bras Ginecol Obstet 2024;46 Epub 2024 Sep 6 doi: 10.61622/rbgo/2024rbgo72. PMID: 39380582Free PMC Article
Hysteroscopy for infertile women: a review.
Cholkeri-Singh A, Sasaki KJ
J Minim Invasive Gynecol 2015 Mar-Apr;22(3):353-62. Epub 2014 Dec 29 doi: 10.1016/j.jmig.2014.12.163. PMID: 25553895
Contemporary management of early pregnancy failure.
Chen BA, Creinin MD
Clin Obstet Gynecol 2007 Mar;50(1):67-88. doi: 10.1097/GRF.0b013e31802f1233. PMID: 17304025
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Therapy

Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Misoprostol and pregnancy.
Goldberg AB, Greenberg MB, Darney PD
N Engl J Med 2001 Jan 4;344(1):38-47. doi: 10.1056/NEJM200101043440107. PMID: 11136959
Intrauterine adhesions: an updated appraisal.
Schenker JG, Margalioth EJ
Fertil Steril 1982 May;37(5):593-610. doi: 10.1016/s0015-0282(16)46268-0. PMID: 6281085
The uterine factor in infertility.
Wallach EE
Fertil Steril 1972 Feb;23(2):138-58. doi: 10.1016/s0015-0282(16)38772-6. PMID: 4551503

Prognosis

Biochemical markers for prediction of the first half pregnancy losses: a review.
Kuspanova M, Gaiday A, Dzhardemaliyeva N, Tuganbayev M, Gorobeiko M, Dinets A, Bermagambetova S, Amirbekova Z, Oraltayeva G, Omertayeva D, Tussupkaliyev A
Rev Bras Ginecol Obstet 2024;46 Epub 2024 Sep 6 doi: 10.61622/rbgo/2024rbgo72. PMID: 39380582Free PMC Article
Medical treatment of miscarriage using misoprostol-a retrospective study.
Meister L, Künnemann I, Fettke F, Lux A, Ignatov A
Arch Gynecol Obstet 2024 Oct;310(4):2115-2121. Epub 2024 Aug 13 doi: 10.1007/s00404-024-07628-6. PMID: 39136729Free PMC Article
Factors Affecting the Success of Repeated Misoprostol Course for the Treatment of Missed Abortion.
Bar-Noy T, Nahshon C, Abu Nasra L, Ostrovsky L, Sagi-Dain L
J Gynecol Obstet Hum Reprod 2022 Dec;51(10):102477. Epub 2022 Sep 11 doi: 10.1016/j.jogoh.2022.102477. PMID: 36103968
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486
Syntocinon induced convulsion.
Pedlow PR
J Obstet Gynaecol Br Commonw 1970 Dec;77(12):1113-4. doi: 10.1111/j.1471-0528.1970.tb03473.x. PMID: 5493616

Clinical prediction guides

Biochemical markers for prediction of the first half pregnancy losses: a review.
Kuspanova M, Gaiday A, Dzhardemaliyeva N, Tuganbayev M, Gorobeiko M, Dinets A, Bermagambetova S, Amirbekova Z, Oraltayeva G, Omertayeva D, Tussupkaliyev A
Rev Bras Ginecol Obstet 2024;46 Epub 2024 Sep 6 doi: 10.61622/rbgo/2024rbgo72. PMID: 39380582Free PMC Article
Medical treatment of miscarriage using misoprostol-a retrospective study.
Meister L, Künnemann I, Fettke F, Lux A, Ignatov A
Arch Gynecol Obstet 2024 Oct;310(4):2115-2121. Epub 2024 Aug 13 doi: 10.1007/s00404-024-07628-6. PMID: 39136729Free PMC Article
Serostatus of Coxsackie B in a sample of women with miscarriage in Baghdad, Iraq.
Jasim MB, Al-Obaidi AB, Abdulrasul EA, Ghazi HF
Hum Antibodies 2024;32(2):61-65. doi: 10.3233/HAB-240005. PMID: 38669524
NGS-Based Application for Routine Non-Invasive Pre-Implantation Genetic Assessment in IVF.
Gombos K, Gálik B, Kalács KI, Gödöny K, Várnagy Á, Alpár D, Bódis J, Gyenesei A, Kovács GL
Int J Mol Sci 2021 Feb 28;22(5) doi: 10.3390/ijms22052443. PMID: 33671014Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article

Recent systematic reviews

Efficacy and safety of oral versus vaginal misoprostol for medical management of first trimester missed abortion: A systematic review and meta-analysis.
Majeed K, Syed H, Murtaza M, Hanif ZM, Ali H
Eur J Obstet Gynecol Reprod Biol 2025 Feb;305:92-99. Epub 2024 Dec 10 doi: 10.1016/j.ejogrb.2024.12.015. PMID: 39673916
Diagnostic value of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio to predict recurrent pregnancy loss and abortion; a systematic review and meta-analysis.
Hantoushzadeh S, Gargar OK, Jafarabady K, Rezaei MM, Asadi F, Eshraghi N, Panahi Z, Shirdel S, Mirzamoradi M, Ghaemi M
Immun Inflamm Dis 2024 Mar;12(3):e1210. doi: 10.1002/iid3.1210. PMID: 38506423Free PMC Article
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis.
Wu HL, Marwah S, Wang P, Wang QM, Chen XW
Sci Rep 2017 May 10;7(1):1664. doi: 10.1038/s41598-017-01892-0. PMID: 28490770Free PMC Article
A systematic review of validated methods to capture stillbirth and spontaneous abortion using administrative or claims data.
Likis FE, Sathe NA, Carnahan R, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K74-82. doi: 10.1016/j.vaccine.2013.03.076. PMID: 24331077

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