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Male Malignant Nipple Neoplasm

MedGen UID:
889752
•Concept ID:
C0948587
•
Neoplastic Process

Definition

A malignant neoplasm that affects the area of the nipple in males. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMale Malignant Nipple Neoplasm

Professional guidelines

PubMed

ACR Appropriateness Criteria® Evaluation of Nipple Discharge: 2022 Update.
Expert Panel on Breast Imaging, Sanford MF, Slanetz PJ, Lewin AA, Baskies AM, Bozzuto L, Branton SA, Hayward JH, Le-Petross HT, Newell MS, Scheel JR, Sharpe RE Jr, Ulaner GA, Weinstein SP, Moy L
J Am Coll Radiol 2022 Nov;19(11S):S304-S318. doi: 10.1016/j.jacr.2022.09.020. PMID: 36436958
Differential diagnosis of benign and malignant male breast lesions in mammography.
Huang Y, Xiao Q, Sun Y, Li Q, Wang S, Gu Y
Eur J Radiol 2020 Nov;132:109339. Epub 2020 Oct 9 doi: 10.1016/j.ejrad.2020.109339. PMID: 33080548
Diagnosis and treatment of abnormal lactation.
Tyson JE, Zacur HA
Clin Obstet Gynecol 1975 Jun;18(2):65-93. doi: 10.1097/00003081-197506000-00005. PMID: 1095274

Recent clinical studies

Etiology

Borrelial pseudolymphoma of the eyebrow in an adult.
Woznica V, Třešková I
Rozhl Chir 2023 Spring;102(2):88-90. doi: 10.33699/PIS.2023.102.2.88-90. PMID: 37185032
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers.
Grimshaw EC, Cohen PR
Dermatol Online J 2013 Jan 15;19(1):4. PMID: 23374946
Male breast cancer.
Fentiman IS, Fourquet A, Hortobagyi GN
Lancet 2006 Feb 18;367(9510):595-604. doi: 10.1016/S0140-6736(06)68226-3. PMID: 16488803
Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
Mannello F, Gazzanelli G
Breast Cancer Res 2001;3(4):238-43. Epub 2001 May 10 doi: 10.1186/bcr302. PMID: 11434875Free PMC Article
Polythelia and testicular cancer.
Goedert JJ, McKeen EA, Javadpour N, Ozols RF, Pottern LM, Fraumeni JF Jr
Ann Intern Med 1984 Nov;101(5):646-7. doi: 10.7326/0003-4819-101-5-646. PMID: 6486596

Diagnosis

Borrelial pseudolymphoma of the eyebrow in an adult.
Woznica V, Třešková I
Rozhl Chir 2023 Spring;102(2):88-90. doi: 10.33699/PIS.2023.102.2.88-90. PMID: 37185032
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Benign breast disease.
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256
Male mammography.
Dershaw DD
AJR Am J Roentgenol 1986 Jan;146(1):127-31. doi: 10.2214/ajr.146.1.127. PMID: 3000153

Therapy

Technical Refinement in Three-Dimensional Nipple-Areola Complex Tattooing of the Reconstructed Breast.
Ruffolo AM, Bruce WJ, Daugherty THF, Lee J, Sommer NZ
Plast Reconstr Surg 2021 Oct 1;148(4):737-746. doi: 10.1097/PRS.0000000000008390. PMID: 34550927
A man with breast discharge and headache.
Maiti A, Das A, Chatterjee S
Eur J Intern Med 2016 Apr;29:e3-4. Epub 2015 Nov 11 doi: 10.1016/j.ejim.2015.11.006. PMID: 26577222
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Primary basal cell carcinoma of the nipple.
Gupta C, Sheth D, Snower DP
Arch Pathol Lab Med 2004 Jul;128(7):792-3. doi: 10.5858/2004-128-792-PBCCOT. PMID: 15214820
Benign breast disease.
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256

Prognosis

Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
Mannello F, Gazzanelli G
Breast Cancer Res 2001;3(4):238-43. Epub 2001 May 10 doi: 10.1186/bcr302. PMID: 11434875Free PMC Article
Perianal Paget's disease.
Amin R
Br J Radiol 1999 Jun;72(858):610-2. doi: 10.1259/bjr.72.858.10560346. PMID: 10560346

Clinical prediction guides

Clinical and sonographic features of nipple lesions.
Cai S, Wang H, Zhu Q, Li J, Sun Q, Jiang Y
Medicine (Baltimore) 2020 Apr;99(15):e19728. doi: 10.1097/MD.0000000000019728. PMID: 32282731Free PMC Article
Comparison of parathyroid hormone kinetics in endoscopic thyroidectomy via bilateral areola with open thyroidectomy.
Zhang D, Wang T, Dionigi G, Zhang J, Zhao Y, Xue G, Liang N, Sun H
BMC Surg 2019 Dec 11;19(1):190. doi: 10.1186/s12893-019-0656-8. PMID: 31829211Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Clinical and ultrasonographic features of male breast tumors: A retrospective analysis.
Yuan WH, Li AF, Chou YH, Hsu HC, Chen YY
PLoS One 2018;13(3):e0194651. Epub 2018 Mar 20 doi: 10.1371/journal.pone.0194651. PMID: 29558507Free PMC Article
Familial multiple cutaneous leiomyomas.
Fernández-Pugnaire MA, Delgado-Florencio V
Dermatology 1995;191(4):295-8. doi: 10.1159/000246578. PMID: 8573925

Recent systematic reviews

Postmastectomy Reconstruction in Male Breast Cancer.
Deldar R, Sayyed AA, Towfighi P, Aminpour N, Sogunro O, Son JD, Fan KL, Song DH
Breast J 2022;2022:5482261. Epub 2022 Mar 29 doi: 10.1155/2022/5482261. PMID: 35711890Free PMC Article
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Bloody nipple discharge as a benign, self-limiting disorder in young children: A systematic review including two related case reports.
Acer T, Derbent M, Hiçsönmez A
J Pediatr Surg 2015 Nov;50(11):1975-82. Epub 2015 Sep 3 doi: 10.1016/j.jpedsurg.2015.08.049. PMID: 26410727
Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review.
Kunath F, Keck B, Antes G, Wullich B, Meerpohl JJ
BMC Med 2012 Aug 28;10:96. doi: 10.1186/1741-7015-10-96. PMID: 22925442Free PMC Article

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