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Cerebrovascular disorder

MedGen UID:: 858
•Concept ID:: C0007820
•: Disease or Syndrome

Synonyms:	Brain Vascular Disorder; Brain Vascular Disorders; Cerebrovascular Disease; Cerebrovascular Diseases; Cerebrovascular Disorder; Cerebrovascular Disorders; Disease, Cerebrovascular; Diseases, Cerebrovascular; Intracranial Vascular Disease; Intracranial Vascular Diseases; Intracranial Vascular Disorder; Intracranial Vascular Disorders; Vascular Disease, Intracranial; Vascular Diseases, Intracranial; Vascular Disorder, Brain; Vascular Disorder, Intracranial; Vascular Disorders, Brain; Vascular Disorders, Intracranial
SNOMED CT:	Cerebrovascular disease (62914000); CVD - Cerebrovascular disease (62914000)

Monarch Initiative:	MONDO:0011057

Definition

A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCerebrovascular disorder

Pathological process
- Disease
  - Disorder by Site
    - Disorder of nervous system
      - Disorder of the central nervous system
        Brain disorder
        Cerebrovascular disorder
        Arteriovenous Malformation, Intracranial
        Vein of Galen malformation
        Basal ganglia cerebrovascular disorder
        Basal ganglia hemorrhage
        Hemorrhage in putamen
        Carotid artery disorder
        Carotid artery dissection
        Common carotid artery dissection
        External carotid artery dissection
        Internal carotid artery dissection
        Carotid artery stenosis
        Carotid artery thrombosis
        Carotid cavernous fistula
        Moyamoya disease
        Central nervous system vasculitis
        Central nervous system AIDS arteritis
        Central nervous system lupus
        Giant cell arteritis
        Cerebral amyloid angiopathy
        Cerebral amyloid angiopathy, APP-related
        ITM2B amyloidosis
        ABri amyloidosis
        ADan amyloidosis
        Cerebral infarction
        Anterior cerebral artery infarction
        Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
        CARASIL syndrome
        Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
        Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2
        Ischemic stroke
        Embolic stroke
        Lacunar stroke
        Thrombotic stroke
        Middle cerebral artery infarction
        Multi-infarct dementia
        Posterior cerebral artery infarction
        Cerebral ischemia
        Transient ischemic attack
        Cerebral Vascular Insufficiency
        Intracranial arterial disease
        Cerebral arterial disease
        Intracranial Aneurysm
        Brain aneurysm
        Cerebral aneurysm
        Intracranial arteriosclerosis
        Vascular dementia
        Intracranial Embolism and Thrombosis
        Intracranial embolism
        Intracranial thrombosis
        Intracranial sinus thrombosis
        Intracranial hemorrhage
        Cerebellar hemorrhage
        Cerebral hemorrhage
        Antenatal intracerebral hemorrhage
        Cerebral Hemorrhage Related to Birth
        Cerebral Intraventricular Hemorrhage
        Intraparenchymal Hemorrhage of the Newborn
        Intraventricular hemorrhage
        Periventricular Hemorrhage of the Newborn
        Recurrent cerebral hemorrhage
        Subependymal Hemorrhage
        Epidural hemorrhage
        Nontraumatic extradural hemorrhage
        Intracranial Hemorrhage, Hypertensive
        Intracranial Tumor Hemorrhage
        Perinatal intracranial hemorrhage
        Intracranial Hemorrhage Related to Birth
        Pituitary apoplexy
        Subarachnoid hemorrhage
        Subarachnoid Hemorrhage Related to Birth
        Subdural hemorrhage
        Hematoma, Subdural, Acute
        Hematoma, Subdural, Chronic
        Spinal subdural hematoma
        Subdural Hemorrhage Related to Birth
        Intracranial vasospasm
        Ischemic encephalopathy
        Brain hypoxia - ischemia
        Brain infarction
        Brain stem infarction
        Vertebrobasilar insufficiency
        Subclavian steal syndrome
        Periventricular leukomalacia
        Cystic Periventricular Leukomalacia
        Small vessel cerebrovascular disease
        Fabry disease
        MELAS syndrome
        Microscopic polyangiitis
        Sneddon syndrome
        Stroke disorder
        COVID-19-Associated Stroke
        Hemorrhagic Stroke
        Non-ischemic Stroke
        Overt Stroke
        Silent Stroke
        Stroke-like episode
        Venous Stroke
        Susac syndrome
        Vascular Depression
        Vascular headache

Professional guidelines

PubMed

Effects of antipsychotic treatment on cardio-cerebrovascular related mortality in schizophrenia: A subanalysis of a systematic review and meta-analysis with meta-regression of moderators.

Solmi M, Croatto G, Gupta A, Fabiano N, Wong S, Fornaro M, Schneider LK, Rohani-Montez SC, Fairley L, Smith N, Bitter I, Gorwood P, Taipale H, Tiihonen J, Cortese S, Dragioti E, Rietz ED, Nielsen RE, Firth J, Fusar-Poli P, Hartman C, Holt RIG, Høye A, Koyanagi A, Larsson H, Lehto K, Lindgren P, Manchia M, Nordentoft M, Skonieczna-Żydecka K, Stubbs B, Vancampfort D, De Prisco M, Boyer L, Vieta E, Correll CU; ECNP Physical And meNtal Health Thematic Working Group (PAN-Health)
Eur Neuropsychopharmacol 2024 Nov;88:6-20. Epub 2024 Aug 8 doi: 10.1016/j.euroneuro.2024.07.009. PMID: 39121717

RNF213 in moyamoya disease: Genotype-phenotype association and the underlying mechanism.

Fang J, Yang X, Ni J
Chin Med J (Engl) 2024 Nov 5;137(21):2552-2560. Epub 2024 Jan 19 doi: 10.1097/CM9.0000000000002985. PMID: 38243713 Free PMC Article

Computerised cognitive behavioural therapy (cCBT): a possible treatment for mood disorders experienced by people with neurological conditions?

Simblett SK, Ring H, Bateman A
Neuropsychol Rehabil 2011 Dec;21(6):925-8. Epub 2011 Sep 15 doi: 10.1080/09602011.2011.592099. PMID: 21919559

See all (17)

Recent clinical studies

Etiology

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies.

Jin J, Duan J, Du L, Xing W, Peng X, Zhao Q
Front Immunol 2022;13:1027756. Epub 2022 Nov 23 doi: 10.3389/fimmu.2022.1027756. PMID: 36505409 Free PMC Article

Endovascular Therapy for Acute Stroke with a Large Ischemic Region.

Yoshimura S, Sakai N, Yamagami H, Uchida K, Beppu M, Toyoda K, Matsumaru Y, Matsumoto Y, Kimura K, Takeuchi M, Yazawa Y, Kimura N, Shigeta K, Imamura H, Suzuki I, Enomoto Y, Tokunaga S, Morita K, Sakakibara F, Kinjo N, Saito T, Ishikura R, Inoue M, Morimoto T
N Engl J Med 2022 Apr 7;386(14):1303-1313. Epub 2022 Feb 9 doi: 10.1056/NEJMoa2118191. PMID: 35138767

Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke.

Sharma S, Nozohouri S, Vaidya B, Abbruscato T
Life Sci 2021 Jun 1;274:119343. Epub 2021 Mar 11 doi: 10.1016/j.lfs.2021.119343. PMID: 33716063 Free PMC Article

Cerebral Venous Thrombosis: What's New?

Aguiar de Sousa D
Hamostaseologie 2021 Feb;41(1):25-30. Epub 2021 Feb 15 doi: 10.1055/a-1332-3042. PMID: 33588451

Parkinsonian syndromes.

Gilman S
Clin Geriatr Med 2006 Nov;22(4):827-42, vi. doi: 10.1016/j.cger.2006.06.007. PMID: 17000338

See all (184)

Diagnosis

Rare combo: moyamoya and lupus in men.

Gökten DB, Gökten M, Deniz Ç, Mercan R
Clin Rheumatol 2024 Jun;43(6):2139-2143. Epub 2024 Apr 16 doi: 10.1007/s10067-024-06960-1. PMID: 38625644

Moyamoya disease emerging as an immune-related angiopathy.

Asselman C, Hemelsoet D, Eggermont D, Dermaut B, Impens F
Trends Mol Med 2022 Nov;28(11):939-950. Epub 2022 Sep 14 doi: 10.1016/j.molmed.2022.08.009. PMID: 36115805

Cerebral Venous Thrombosis: What's New?

Aguiar de Sousa D
Hamostaseologie 2021 Feb;41(1):25-30. Epub 2021 Feb 15 doi: 10.1055/a-1332-3042. PMID: 33588451

Oligodendrocytes in intracerebral hemorrhage.

Kang M, Yao Y
CNS Neurosci Ther 2019 Oct;25(10):1075-1084. Epub 2019 Aug 14 doi: 10.1111/cns.13193. PMID: 31410988 Free PMC Article

Parkinsonian syndromes.

Gilman S
Clin Geriatr Med 2006 Nov;22(4):827-42, vi. doi: 10.1016/j.cger.2006.06.007. PMID: 17000338

See all (147)

Therapy

Traditional Chinese medicines derived natural inhibitors of ferroptosis on ischemic stroke.

Wang Y, Lan X, Liu N, Ma L, DU J, Wei W, Hai D, Wu J, Yu J, Liu Y
Chin J Nat Med 2024 Aug;22(8):746-755. doi: 10.1016/S1875-5364(24)60603-5. PMID: 39197964

Dexmedetomidine treatment prevents cerebral ischemic reperfusion injury through HIF-1α/Beclin1-mediated autophagy.

He Z, Su H, Wu H, Wang L, Gao Y, Zhang H, Yan S
Brain Inj 2023 Jul 3;37(8):706-713. Epub 2022 Dec 17 doi: 10.1080/02699052.2022.2158235. PMID: 36527380

Endovascular Therapy for Acute Stroke with a Large Ischemic Region.

Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke.

Sharma S, Nozohouri S, Vaidya B, Abbruscato T
Life Sci 2021 Jun 1;274:119343. Epub 2021 Mar 11 doi: 10.1016/j.lfs.2021.119343. PMID: 33716063 Free PMC Article

Reversible cerebral vasoconstriction syndrome.

Yancy H, Lee-Iannotti JK, Schwedt TJ, Dodick DW
Headache 2013 Mar;53(3):570-6. doi: 10.1111/head.12040. PMID: 23489219

See all (81)

Prognosis

Angiopoietin-2 associates with poor prognosis in Moyamoya angiopathy.

Gorla G, Potenza A, Carrozzini T, Pollaci G, Acerbi F, Vetrano IG, Ferroli P, Canavero I, Rifino N, Bersano A, Gatti L
Ann Clin Transl Neurol 2024 Jun;11(6):1590-1603. Epub 2024 Apr 24 doi: 10.1002/acn3.52076. PMID: 38655722 Free PMC Article

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies.

Jin J, Duan J, Du L, Xing W, Peng X, Zhao Q
Front Immunol 2022;13:1027756. Epub 2022 Nov 23 doi: 10.3389/fimmu.2022.1027756. PMID: 36505409 Free PMC Article

Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya.

Wenz H, Wenz R, Maros M, Ehrlich G, Al-Zghloul M, Groden C, Förster A
Stroke 2017 Feb;48(2):307-313. Epub 2017 Jan 6 doi: 10.1161/STROKEAHA.116.014335. PMID: 28062861

Parkinsonian syndromes.

Gilman S
Clin Geriatr Med 2006 Nov;22(4):827-42, vi. doi: 10.1016/j.cger.2006.06.007. PMID: 17000338

Treatment of aneurysmal subarachnoid haemorrhage in elderly patients.

Sarkar PK, D'Souza C, Ballantyne S
J Clin Pharm Ther 2001 Aug;26(4):247-56. doi: 10.1046/j.1365-2710.2001.00349.x. PMID: 11493366

See all (92)

Clinical prediction guides

Rare combo: moyamoya and lupus in men.

Gökten DB, Gökten M, Deniz Ç, Mercan R
Clin Rheumatol 2024 Jun;43(6):2139-2143. Epub 2024 Apr 16 doi: 10.1007/s10067-024-06960-1. PMID: 38625644

Endovascular Therapy for Acute Stroke with a Large Ischemic Region.

Effects of Balance Exercise Assist Robot training for patients with hemiparetic stroke: a randomized controlled trial.

Inoue S, Otaka Y, Kumagai M, Sugasawa M, Mori N, Kondo K
J Neuroeng Rehabil 2022 Jan 28;19(1):12. doi: 10.1186/s12984-022-00989-6. PMID: 35090517 Free PMC Article

Charcot and Cholesterin.

Walusinski O
Eur Neurol 2019;81(5-6):309-318. Epub 2019 Sep 5 doi: 10.1159/000502576. PMID: 31487724

Long-term outcome of basilar stenosis in Erdheim-Chester disease: A case report.

Mathis S, Godenèche G, Haroche J, Milin S, Julian A, Berthomet A, Baron C, Palazzo P, Neau JP
Medicine (Baltimore) 2016 Sep;95(36):e4813. doi: 10.1097/MD.0000000000004813. PMID: 27603396 Free PMC Article

See all (122)

Recent systematic reviews

Effects of antipsychotic treatment on cardio-cerebrovascular related mortality in schizophrenia: A subanalysis of a systematic review and meta-analysis with meta-regression of moderators.

Lower limb muscle synergies during walking after stroke: a systematic review.

Van Criekinge T, Vermeulen J, Wagemans K, Schröder J, Embrechts E, Truijen S, Hallemans A, Saeys W
Disabil Rehabil 2020 Oct;42(20):2836-2845. Epub 2019 Mar 23 doi: 10.1080/09638288.2019.1578421. PMID: 30905215

When and why is surgical revascularization indicated for the treatment of moyamoya syndrome in patients with RASopathies? A systematic review of the literature and a single institute experience.

Scala M, Fiaschi P, Capra V, Garrè ML, Tortora D, Ravegnani M, Pavanello M
Childs Nerv Syst 2018 Jul;34(7):1311-1323. Epub 2018 May 24 doi: 10.1007/s00381-018-3833-7. PMID: 29797062

Cognitive Outcomes following Thrombolysis in Acute Ischemic Stroke: A Systematic Review.

Broome LJ, Battle CE, Lawrence M, Evans PA, Dennis MS
J Stroke Cerebrovasc Dis 2016 Dec;25(12):2868-2875. Epub 2016 Aug 25 doi: 10.1016/j.jstrokecerebrovasdis.2016.07.048. PMID: 27569709

Systematic review of reversible cerebral vasoconstriction syndrome.

Sattar A, Manousakis G, Jensen MB
Expert Rev Cardiovasc Ther 2010 Oct;8(10):1417-21. doi: 10.1586/erc.10.124. PMID: 20936928 Free PMC Article

See all (14)

MedGen

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Send to:

Cerebrovascular disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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