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Recurrent Neuroblastoma

MedGen UID:
78867
•Concept ID:
C0278695
•
Neoplastic Process
Synonym: Relapsed Neuroblastoma

Definition

The reemergence of neuroblastoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Neuroblastoma

Professional guidelines

PubMed

Multimodality treatment for recurrent neuroblastoma in the central nervous system.
Desai AV, Elmuti L, Cahaney C, De Guzman RM, Streby KA, Cohn SL
Pediatr Blood Cancer 2023 Apr;70(4):e30227. Epub 2023 Jan 31 doi: 10.1002/pbc.30227. PMID: 36720647
Feasibility of implementing molecular-guided therapy for the treatment of patients with relapsed or refractory neuroblastoma.
Saulnier Sholler GL, Bond JP, Bergendahl G, Dutta A, Dragon J, Neville K, Ferguson W, Roberts W, Eslin D, Kraveka J, Kaplan J, Mitchell D, Parikh N, Merchant M, Ashikaga T, Hanna G, Lescault PJ, Siniard A, Corneveaux J, Huentelman M, Trent J
Cancer Med 2015 Jun;4(6):871-86. Epub 2015 Feb 26 doi: 10.1002/cam4.436. PMID: 25720842Free PMC Article
Detection and treatment of minimal residual disease in high-risk neuroblastoma.
Reynolds CP
Pediatr Transplant 2004 Jun;8 Suppl 5:56-66. doi: 10.1111/j.1398-2265.2004.00216.x. PMID: 15125707

Recent clinical studies

Etiology

Long-term survival of two patients with recurrent high-risk neuroblastoma.
Sato T, Hara K, Ohba G, Yamamoto H, Iguchi A
Pediatr Int 2021 Jul;63(7):849-851. Epub 2021 Apr 27 doi: 10.1111/ped.14489. PMID: 33904642
Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma.
Bagley AF, Grosshans DR, Philip NV, Foster J, McAleer MF, McGovern SL, Lassen-Ramshad Y, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Aug;66(8):e27786. Epub 2019 May 2 doi: 10.1002/pbc.27786. PMID: 31050179Free PMC Article
Diagnostic utility of core needle biopsy versus open wedge biopsy for pediatric intraabdominal solid tumors: Results of a prospective clinical study.
Deeney S, Stewart C, Treece AL, Black JO, Lovell MA, Garrington T, Karrer F, Bruny J
J Pediatr Surg 2017 Dec;52(12):2042-2046. Epub 2017 Sep 4 doi: 10.1016/j.jpedsurg.2017.08.032. PMID: 28943139
Historical time to disease progression and progression-free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early-phase trials.
London WB, Bagatell R, Weigel BJ, Fox E, Guo D, Van Ryn C, Naranjo A, Park JR
Cancer 2017 Dec 15;123(24):4914-4923. Epub 2017 Sep 8 doi: 10.1002/cncr.30934. PMID: 28885700Free PMC Article
Children's Oncology Group's 2013 blueprint for research: neuroblastoma.
Park JR, Bagatell R, London WB, Maris JM, Cohn SL, Mattay KK, Hogarty M; COG Neuroblastoma Committee
Pediatr Blood Cancer 2013 Jun;60(6):985-93. Epub 2012 Dec 19 doi: 10.1002/pbc.24433. PMID: 23255319

Diagnosis

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma.
Sen A, Huo Y, Elster J, Zage PE, McVicker G
Genome Biol 2022 Mar 4;23(1):71. doi: 10.1186/s13059-022-02640-y. PMID: 35246212Free PMC Article
Long-term survival of two patients with recurrent high-risk neuroblastoma.
Sato T, Hara K, Ohba G, Yamamoto H, Iguchi A
Pediatr Int 2021 Jul;63(7):849-851. Epub 2021 Apr 27 doi: 10.1111/ped.14489. PMID: 33904642
Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere maintenance.
Fransson S, Martinez-Monleon A, Johansson M, Sjöberg RM, Björklund C, Ljungman G, Ek T, Kogner P, Martinsson T
Sci Rep 2020 Dec 31;10(1):22432. doi: 10.1038/s41598-020-78370-7. PMID: 33384420Free PMC Article
Historical time to disease progression and progression-free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early-phase trials.
London WB, Bagatell R, Weigel BJ, Fox E, Guo D, Van Ryn C, Naranjo A, Park JR
Cancer 2017 Dec 15;123(24):4914-4923. Epub 2017 Sep 8 doi: 10.1002/cncr.30934. PMID: 28885700Free PMC Article
Recurrent neuroblastoma with gastric invasion.
Caudill J, Giles H, Megason G, Wyatt-Ashmead J, Gosche J, Nowicki M
J Pediatr Hematol Oncol 2004 Aug;26(8):476-9. doi: 10.1097/01.mph.0000130932.41408.82. PMID: 15284582

Therapy

Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3×anti-GD2 bispecific antibody armed T cells.
Yankelevich M, Thakur A, Modak S, Chu R, Taub J, Martin A, Schalk D, Schienshang A, Whitaker S, Rea K, Lee DW, Liu Q, Shields AF, Cheung NV, Lum LG
J Immunother Cancer 2024 Mar 21;12(3) doi: 10.1136/jitc-2023-008744. PMID: 38519053Free PMC Article
GD2-specific chimeric antigen receptor-modified T cells for the treatment of refractory and/or recurrent neuroblastoma in pediatric patients.
Yu L, Huang L, Lin D, Lai X, Wu L, Liao X, Liu J, Zeng Y, Liang L, Zhang G, Wang B, Wu Z, Tao S, Liu Y, Jiao C, Chang LJ, Yang L
J Cancer Res Clin Oncol 2022 Oct;148(10):2643-2652. Epub 2021 Nov 1 doi: 10.1007/s00432-021-03839-5. PMID: 34724115Free PMC Article
hu3F8 for resistant or recurrent neuroblastoma.
Burki TK
Lancet Oncol 2018 Nov;19(11):e583. Epub 2018 Sep 27 doi: 10.1016/S1470-2045(18)30738-1. PMID: 30269905
Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives.
Cooper JP, Reynolds CP, Cho H, Kang MH
Exp Biol Med (Maywood) 2017 Jun;242(11):1178-1184. Epub 2017 Apr 21 doi: 10.1177/1535370217706952. PMID: 28429653Free PMC Article
Elevated MIBG Activity at the Site of Erythema of Unknown Etiology.
Xie P, Monaghan R, Edwards K, Shao F, Zhuang H
Clin Nucl Med 2017 Mar;42(3):227-230. doi: 10.1097/RLU.0000000000001494. PMID: 27997425

Prognosis

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma.
Sen A, Huo Y, Elster J, Zage PE, McVicker G
Genome Biol 2022 Mar 4;23(1):71. doi: 10.1186/s13059-022-02640-y. PMID: 35246212Free PMC Article
Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere maintenance.
Fransson S, Martinez-Monleon A, Johansson M, Sjöberg RM, Björklund C, Ljungman G, Ek T, Kogner P, Martinsson T
Sci Rep 2020 Dec 31;10(1):22432. doi: 10.1038/s41598-020-78370-7. PMID: 33384420Free PMC Article
Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma.
Bagley AF, Grosshans DR, Philip NV, Foster J, McAleer MF, McGovern SL, Lassen-Ramshad Y, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Aug;66(8):e27786. Epub 2019 May 2 doi: 10.1002/pbc.27786. PMID: 31050179Free PMC Article
Historical time to disease progression and progression-free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early-phase trials.
London WB, Bagatell R, Weigel BJ, Fox E, Guo D, Van Ryn C, Naranjo A, Park JR
Cancer 2017 Dec 15;123(24):4914-4923. Epub 2017 Sep 8 doi: 10.1002/cncr.30934. PMID: 28885700Free PMC Article
Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma.
Takahashi H, Manabe A, Aoyama C, Kamiya T, Kato I, Takusagawa A, Ogawa C, Ozawa M, Hosoya R, Yokoyama K
Pediatr Blood Cancer 2008 Mar;50(3):676-8. doi: 10.1002/pbc.21126. PMID: 17243128

Clinical prediction guides

Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3×anti-GD2 bispecific antibody armed T cells.
Yankelevich M, Thakur A, Modak S, Chu R, Taub J, Martin A, Schalk D, Schienshang A, Whitaker S, Rea K, Lee DW, Liu Q, Shields AF, Cheung NV, Lum LG
J Immunother Cancer 2024 Mar 21;12(3) doi: 10.1136/jitc-2023-008744. PMID: 38519053Free PMC Article
Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma.
Sen A, Huo Y, Elster J, Zage PE, McVicker G
Genome Biol 2022 Mar 4;23(1):71. doi: 10.1186/s13059-022-02640-y. PMID: 35246212Free PMC Article
Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma.
Bagley AF, Grosshans DR, Philip NV, Foster J, McAleer MF, McGovern SL, Lassen-Ramshad Y, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Aug;66(8):e27786. Epub 2019 May 2 doi: 10.1002/pbc.27786. PMID: 31050179Free PMC Article
Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives.
Cooper JP, Reynolds CP, Cho H, Kang MH
Exp Biol Med (Maywood) 2017 Jun;242(11):1178-1184. Epub 2017 Apr 21 doi: 10.1177/1535370217706952. PMID: 28429653Free PMC Article
Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma.
Takahashi H, Manabe A, Aoyama C, Kamiya T, Kato I, Takusagawa A, Ogawa C, Ozawa M, Hosoya R, Yokoyama K
Pediatr Blood Cancer 2008 Mar;50(3):676-8. doi: 10.1002/pbc.21126. PMID: 17243128

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