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Childhood acute myeloid leukemia

MedGen UID:
65075
•Concept ID:
C0220621
•
Neoplastic Process
Synonyms: acute myeloid leukaemia of childhood; acute myeloid leukemia of childhood; childhood acute granulocytic leukaemia; childhood acute granulocytic leukemia; childhood acute myeloblastic leukaemia; Childhood Acute Myeloblastic Leukemia; childhood acute myeloblastic leukemia; childhood acute myelocytic leukaemia; childhood acute myelocytic leukemia; childhood acute myelogenous leukaemia; Childhood Acute Myelogenous Leukemia; childhood acute myelogenous leukemia; Childhood Acute Myeloid Leukemia; childhood acute myeloid leukemia; Childhood AML; childhood AML; paediatric acute myeloblastic leukaemia; paediatric acute myelocytic leukaemia; paediatric acute myelogenous leukaemia; paediatric acute myeloid leukaemia; paediatric AML; Pediatric Acute Myeloblastic Leukemia; pediatric acute myeloblastic leukemia; pediatric acute myelocytic leukemia; Pediatric Acute Myelogenous Leukemia; pediatric acute myelogenous leukemia; Pediatric Acute Myeloid Leukemia; pediatric acute myeloid leukemia; Pediatric AML; pediatric AML
 
Monarch Initiative: MONDO:0004996

Definition

Acute myeloid leukemia occurring in childhood. [from NCI]

Professional guidelines

PubMed

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.
Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029
Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.
Burnusuzov HA, Yordanova MN, Avramova BE, Yurukova NN, Bachvarov KN, Muchinova AB, Vlahova IH, Stoyanova AA, Mumdzhiev IN, Ivanova LR, Spasov NY, Peteva ET, Belcheva MI, Hristozova H, Spasova MI, Kaleva VI, Bobev D, Konstantinov DN
Folia Med (Plovdiv) 2018 Jun 1;60(2):234-240. doi: 10.1515/folmed-2017-0090. PMID: 30355812
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Recent clinical studies

Etiology

Inherent genome instability underlies trisomy 21-associated myeloid malignancies.
Chen CC, Silberman RE, Ma D, Perry JA, Khalid D, Pikman Y, Amon A, Hemann MT, Rowe RG
Leukemia 2024 Mar;38(3):521-529. Epub 2024 Jan 20 doi: 10.1038/s41375-024-02151-8. PMID: 38245602
Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Childhood acute myeloid leukemia.
Rubnitz JE
Curr Treat Options Oncol 2008 Feb;9(1):95-105. Epub 2008 May 28 doi: 10.1007/s11864-008-0059-z. PMID: 18506629

Diagnosis

Optimal dosing of cytarabine in childhood acute myeloid leukemia: do we have the answer yet?
Srinivasan S
Leuk Lymphoma 2022 Dec;63(12):3015-3017. Epub 2022 Aug 1 doi: 10.1080/10428194.2022.2105327. PMID: 35913395
Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Epidemiology of childhood acute myeloid leukemia.
Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597Free PMC Article
Presentation of childhood acute myeloid leukemia with erythema nodosum.
La Spina M, Russo G
J Clin Oncol 2007 Sep 1;25(25):4011-2. doi: 10.1200/JCO.2007.12.0022. PMID: 17761986

Therapy

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.
Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029
Optimal dosing of cytarabine in childhood acute myeloid leukemia: do we have the answer yet?
Srinivasan S
Leuk Lymphoma 2022 Dec;63(12):3015-3017. Epub 2022 Aug 1 doi: 10.1080/10428194.2022.2105327. PMID: 35913395
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Sequential treatment with cytarabine and decitabine has an increased anti-leukemia effect compared to cytarabine alone in xenograft models of childhood acute myeloid leukemia.
Leonard SM, Perry T, Woodman CB, Kearns P
PLoS One 2014;9(1):e87475. Epub 2014 Jan 28 doi: 10.1371/journal.pone.0087475. PMID: 24489920Free PMC Article

Prognosis

Relapsed Childhood Acute Myeloid Leukemia: Experience from a Single Tertiary Center in Thailand.
Songthawee N, Sripornsawan P, Chavananon S, McNeil EB, Chotsampancharoen T
Asian Pac J Cancer Prev 2022 Dec 1;23(12):4079-4084. doi: 10.31557/APJCP.2022.23.12.4079. PMID: 36579988Free PMC Article
Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905Free PMC Article
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article

Clinical prediction guides

The Role of Gender-Related Immune Genes in Childhood Acute Myeloid Leukemia.
Hao L, Chen Q, Chen X, Zhou Q
Biomed Res Int 2022;2022:3235238. Epub 2022 Sep 23 doi: 10.1155/2022/3235238. PMID: 36193320Free PMC Article
Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905Free PMC Article
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies.
Kolb EA, Meshinchi S
Hematology Am Soc Hematol Educ Program 2015;2015:507-13. doi: 10.1182/asheducation-2015.1.507. PMID: 26637766
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article

Recent systematic reviews

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Skalkidou A, Biniaris-Georgallis S-, Kalogirou ΕΙ, Thomopoulos TP, Herlenius E, Spector LG, Loutradis D, Chrousos GP, Petridou ET
Cancer Causes Control 2017 Jun;28(6):599-624. Epub 2017 Apr 11 doi: 10.1007/s10552-017-0890-2. PMID: 28401353
Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis.
Latino-Martel P, Chan DS, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat T
Cancer Epidemiol Biomarkers Prev 2010 May;19(5):1238-60. doi: 10.1158/1055-9965.EPI-09-1110. PMID: 20447918

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