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COL1A1 Associated Connective Tissue Disorder

MedGen UID:
396965
Concept ID:
C2698737
Disease or Syndrome

Definition

A group of connective tissue disorder caused by mutations in the COL1A1 gene mapped to chromosome 17q21. It includes the Ehlers-Danlos syndrome, osteogenesis imperfecta, and osteoporosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCOL1A1 Associated Connective Tissue Disorder

Professional guidelines

PubMed

MacCarrick G, Aradhya S, Bailey M, Chu D, Hunt A, Izzo E, Krakow D, Mackenzie W, Poll S, Raggio C, Shediac R, White KK, McLaughlin HM, Seratti G
Am J Med Genet A 2024 Sep;194(9):e63646. Epub 2024 May 3 doi: 10.1002/ajmg.a.63646. PMID: 38702915
Leone MP, Morlino S, Nardella G, Pracella R, Giachino D, Celli L, Baldo D, Turolla L, Piccione M, Salzano E, Busè M, Lastella P, Zollino M, Cantone R, Grosso E, Zonta A, Pasini B, Piscopo C, De Maggio I, Priolo M, Mammi C, Foiadelli T, Trabatti C, Savasta S, Iolascon A, Ferraris A, Lodato V, Di Giosaffatte N, Majore S, Selicorni A, Petracca A, Fusco C, Celli M, Guarnieri V, Micale L, Castori M
Hum Genet 2023 Jun;142(6):785-808. Epub 2023 Apr 20 doi: 10.1007/s00439-023-02547-z. PMID: 37079061
Lindahl K, Åström E, Rubin CJ, Grigelioniene G, Malmgren B, Ljunggren Ö, Kindmark A
Eur J Hum Genet 2015 Aug;23(8):1042-50. Epub 2015 May 6 doi: 10.1038/ejhg.2015.81. PMID: 25944380Free PMC Article

Recent clinical studies

Etiology

Glorieux FH, Langdahl B, Chapurlat R, De Beur SJ, Sutton VR, Poole KES, Dahir KM, Orwoll ES, Willie BM, Mikolajewicz N, Zimmermann E, Hosseinitabatabaei S, Ominsky MS, Saville C, Clancy J, MacKinnon A, Mistry A, Javaid MK
J Bone Miner Res 2024 Sep 2;39(9):1215-1228. doi: 10.1093/jbmr/zjae112. PMID: 39012717Free PMC Article
MacCarrick G, Aradhya S, Bailey M, Chu D, Hunt A, Izzo E, Krakow D, Mackenzie W, Poll S, Raggio C, Shediac R, White KK, McLaughlin HM, Seratti G
Am J Med Genet A 2024 Sep;194(9):e63646. Epub 2024 May 3 doi: 10.1002/ajmg.a.63646. PMID: 38702915
Harsanyi S, Zamborsky R, Krajciova L, Kokavec M, Danisovic L
Medicina (Kaunas) 2020 Mar 31;56(4) doi: 10.3390/medicina56040153. PMID: 32244273Free PMC Article
Tournis S, Dede AD
Metabolism 2018 Mar;80:27-37. Epub 2017 Jun 8 doi: 10.1016/j.metabol.2017.06.001. PMID: 28625337
Wallace MJ, Kruse RW, Shah SA
J Am Acad Orthop Surg 2017 Feb;25(2):100-109. doi: 10.5435/JAAOS-D-15-00169. PMID: 28009707

Diagnosis

Glorieux FH, Langdahl B, Chapurlat R, De Beur SJ, Sutton VR, Poole KES, Dahir KM, Orwoll ES, Willie BM, Mikolajewicz N, Zimmermann E, Hosseinitabatabaei S, Ominsky MS, Saville C, Clancy J, MacKinnon A, Mistry A, Javaid MK
J Bone Miner Res 2024 Sep 2;39(9):1215-1228. doi: 10.1093/jbmr/zjae112. PMID: 39012717Free PMC Article
Leone MP, Morlino S, Nardella G, Pracella R, Giachino D, Celli L, Baldo D, Turolla L, Piccione M, Salzano E, Busè M, Lastella P, Zollino M, Cantone R, Grosso E, Zonta A, Pasini B, Piscopo C, De Maggio I, Priolo M, Mammi C, Foiadelli T, Trabatti C, Savasta S, Iolascon A, Ferraris A, Lodato V, Di Giosaffatte N, Majore S, Selicorni A, Petracca A, Fusco C, Celli M, Guarnieri V, Micale L, Castori M
Hum Genet 2023 Jun;142(6):785-808. Epub 2023 Apr 20 doi: 10.1007/s00439-023-02547-z. PMID: 37079061
Venable E, Knight DRT, Thoreson EK, Baudhuin LM
Am J Med Genet C Semin Med Genet 2023 Jun;193(2):147-159. Epub 2023 Mar 9 doi: 10.1002/ajmg.c.32038. PMID: 36896471
Marom R, Rabenhorst BM, Morello R
Eur J Endocrinol 2020 Oct;183(4):R95-R106. doi: 10.1530/EJE-20-0299. PMID: 32621590Free PMC Article
Li L, Mao B, Li S, Xiao J, Wang H, Zhang J, Ren X, Wang Y, Wu Y, Cao Y, Lu C, Gao J, You Y, Zhao F, Geng X, Xiao Y, Jiang C, Ye Y, Yang T, Zhao X, Zhang X
Hum Mutat 2019 May;40(5):588-600. Epub 2019 Feb 25 doi: 10.1002/humu.23718. PMID: 30715774

Therapy

Glorieux FH, Langdahl B, Chapurlat R, De Beur SJ, Sutton VR, Poole KES, Dahir KM, Orwoll ES, Willie BM, Mikolajewicz N, Zimmermann E, Hosseinitabatabaei S, Ominsky MS, Saville C, Clancy J, MacKinnon A, Mistry A, Javaid MK
J Bone Miner Res 2024 Sep 2;39(9):1215-1228. doi: 10.1093/jbmr/zjae112. PMID: 39012717Free PMC Article
Corrêa T, Feltes BC, Gonzalez EA, Baldo G, Matte U
Interdiscip Sci 2021 Mar;13(1):34-43. Epub 2021 Jan 21 doi: 10.1007/s12539-020-00406-3. PMID: 33475959
Maioli M, Gnoli M, Boarini M, Tremosini M, Zambrano A, Pedrini E, Mordenti M, Corsini S, D'Eufemia P, Versacci P, Celli M, Sangiorgi L
Eur J Hum Genet 2019 Jul;27(7):1090-1100. Epub 2019 Mar 18 doi: 10.1038/s41431-019-0373-x. PMID: 30886339Free PMC Article
Palomo T, Al-Jallad H, Moffatt P, Glorieux FH, Lentle B, Roschger P, Klaushofer K, Rauch F
Bone 2014 Oct;67:63-70. Epub 2014 Jul 8 doi: 10.1016/j.bone.2014.06.041. PMID: 25010833
McKenna MJ, Kristiansen AG, Bartley ML, Rogus JJ, Haines JL
Am J Otol 1998 Sep;19(5):604-10. PMID: 9752968

Prognosis

Leone MP, Morlino S, Nardella G, Pracella R, Giachino D, Celli L, Baldo D, Turolla L, Piccione M, Salzano E, Busè M, Lastella P, Zollino M, Cantone R, Grosso E, Zonta A, Pasini B, Piscopo C, De Maggio I, Priolo M, Mammi C, Foiadelli T, Trabatti C, Savasta S, Iolascon A, Ferraris A, Lodato V, Di Giosaffatte N, Majore S, Selicorni A, Petracca A, Fusco C, Celli M, Guarnieri V, Micale L, Castori M
Hum Genet 2023 Jun;142(6):785-808. Epub 2023 Apr 20 doi: 10.1007/s00439-023-02547-z. PMID: 37079061
Dachy G, Fraitag S, Boulouadnine B, Cordi S, Demoulin JB
J Cell Mol Med 2021 May;25(9):4387-4394. Epub 2021 Apr 8 doi: 10.1111/jcmm.16502. PMID: 33830670Free PMC Article
Maioli M, Gnoli M, Boarini M, Tremosini M, Zambrano A, Pedrini E, Mordenti M, Corsini S, D'Eufemia P, Versacci P, Celli M, Sangiorgi L
Eur J Hum Genet 2019 Jul;27(7):1090-1100. Epub 2019 Mar 18 doi: 10.1038/s41431-019-0373-x. PMID: 30886339Free PMC Article
Lindahl K, Åström E, Rubin CJ, Grigelioniene G, Malmgren B, Ljunggren Ö, Kindmark A
Eur J Hum Genet 2015 Aug;23(8):1042-50. Epub 2015 May 6 doi: 10.1038/ejhg.2015.81. PMID: 25944380Free PMC Article
Tsipouras P, Schwartz RC, Goldberg JD, Berkowitz RL, Ramirez F
J Med Genet 1987 Jul;24(7):406-9. doi: 10.1136/jmg.24.7.406. PMID: 2886666Free PMC Article

Clinical prediction guides

Leone MP, Morlino S, Nardella G, Pracella R, Giachino D, Celli L, Baldo D, Turolla L, Piccione M, Salzano E, Busè M, Lastella P, Zollino M, Cantone R, Grosso E, Zonta A, Pasini B, Piscopo C, De Maggio I, Priolo M, Mammi C, Foiadelli T, Trabatti C, Savasta S, Iolascon A, Ferraris A, Lodato V, Di Giosaffatte N, Majore S, Selicorni A, Petracca A, Fusco C, Celli M, Guarnieri V, Micale L, Castori M
Hum Genet 2023 Jun;142(6):785-808. Epub 2023 Apr 20 doi: 10.1007/s00439-023-02547-z. PMID: 37079061
Venable E, Knight DRT, Thoreson EK, Baudhuin LM
Am J Med Genet C Semin Med Genet 2023 Jun;193(2):147-159. Epub 2023 Mar 9 doi: 10.1002/ajmg.c.32038. PMID: 36896471
Dachy G, Fraitag S, Boulouadnine B, Cordi S, Demoulin JB
J Cell Mol Med 2021 May;25(9):4387-4394. Epub 2021 Apr 8 doi: 10.1111/jcmm.16502. PMID: 33830670Free PMC Article
Maioli M, Gnoli M, Boarini M, Tremosini M, Zambrano A, Pedrini E, Mordenti M, Corsini S, D'Eufemia P, Versacci P, Celli M, Sangiorgi L
Eur J Hum Genet 2019 Jul;27(7):1090-1100. Epub 2019 Mar 18 doi: 10.1038/s41431-019-0373-x. PMID: 30886339Free PMC Article
Lindahl K, Åström E, Rubin CJ, Grigelioniene G, Malmgren B, Ljunggren Ö, Kindmark A
Eur J Hum Genet 2015 Aug;23(8):1042-50. Epub 2015 May 6 doi: 10.1038/ejhg.2015.81. PMID: 25944380Free PMC Article

Recent systematic reviews

Martín-Martín M, Cortés-Martín J, Tovar-Gálvez MI, Sánchez-García JC, Díaz-Rodríguez L, Rodríguez-Blanque R
Int J Environ Res Public Health 2022 Feb 7;19(3) doi: 10.3390/ijerph19031870. PMID: 35162892Free PMC Article

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