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Celiac disease, susceptibility to, 9(CELIAC9)

MedGen UID:
393783
Concept ID:
C2677605
Finding
Synonyms: Celiac disease 9; CELIAC9; GLUTEN-SENSITIVE ENTEROPATHY, SUSCEPTIBILITY TO, 9
 
Monarch Initiative: MONDO:0012778
OMIM®: 612007

Definition

Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). For additional information and a discussion of genetic heterogeneity of celiac disease, see 212750. [from OMIM]

Professional guidelines

PubMed

Shi T, Liu W, Li T, Liu H, Hui W, Lin Q, Han X, Gao F
Scand J Gastroenterol 2023 May;58(5):471-476. Epub 2022 Nov 22 doi: 10.1080/00365521.2022.2147801. PMID: 36415137
Gudeta AN, Ramelius A, Balcha TT, Girma A, Ilonen J, Agardh D
HLA 2020 Dec;96(6):681-687. Epub 2020 Oct 30 doi: 10.1111/tan.14119. PMID: 33094564Free PMC Article
Van Driessche F, Silverberg N
Paediatr Drugs 2015 Aug;17(4):303-13. doi: 10.1007/s40272-015-0135-3. PMID: 26022363

Recent clinical studies

Etiology

Sun D, Ma R, Wang J, Wang Y, Ye Q
Front Immunol 2024;15:1325127. Epub 2024 Apr 22 doi: 10.3389/fimmu.2024.1325127. PMID: 38711527Free PMC Article
Wen J, Zhang J, Zhang H, Zhang N, Lei R, Deng Y, Cheng Q, Li H, Luo P
J Transl Med 2024 Apr 29;22(1):392. doi: 10.1186/s12967-024-04928-y. PMID: 38685026Free PMC Article
Makharia GK, Chauhan A, Singh P, Ahuja V
Aliment Pharmacol Ther 2022 Jul;56 Suppl 1:S3-S17. doi: 10.1111/apt.16787. PMID: 35815830
Emiralioglu N, Ademhan Tural D, Hizarcioglu Gulsen H, Ergen YM, Ozsezen B, Sunman B, Saltık Temizel İ, Yalcin E, Dogru D, Ozcelik U, Kiper N
Eur J Pediatr 2021 Sep;180(9):2807-2813. Epub 2021 Mar 25 doi: 10.1007/s00431-021-04011-4. PMID: 33765186
Hemminki K, Li X, Sundquist K, Sundquist J
Arthritis Rheum 2009 Sep;60(9):2845-7. doi: 10.1002/art.24749. PMID: 19714648

Diagnosis

Ghisleni C, Parma B, Cianci P, De Paoli A, Pangallo E, Agovino T, Cereda A, Bedeschi MF, Villa R, Fossati C, Modena P, Giudici C, Morando C, Memo L, Onesimo R, Zampino G, Salvatore S, Agosti M, Selicorni A
Am J Med Genet A 2023 Jan;191(1):84-89. Epub 2022 Oct 18 doi: 10.1002/ajmg.a.62990. PMID: 36254687
Makharia GK, Chauhan A, Singh P, Ahuja V
Aliment Pharmacol Ther 2022 Jul;56 Suppl 1:S3-S17. doi: 10.1111/apt.16787. PMID: 35815830
Emiralioglu N, Ademhan Tural D, Hizarcioglu Gulsen H, Ergen YM, Ozsezen B, Sunman B, Saltık Temizel İ, Yalcin E, Dogru D, Ozcelik U, Kiper N
Eur J Pediatr 2021 Sep;180(9):2807-2813. Epub 2021 Mar 25 doi: 10.1007/s00431-021-04011-4. PMID: 33765186
Soderquist CR, Lewis SK, Gru AA, Vlad G, Williams ES, Hsiao S, Mansukhani MM, Park DC, Bacchi CE, Alobeid B, Green PH, Bhagat G
Am J Surg Pathol 2021 Jul 1;45(7):905-916. doi: 10.1097/PAS.0000000000001658. PMID: 33544565
Pellicano R, De Angelis C, Ribaldone DG, Fagoonee S, Astegiano M
Nutrients 2013 Aug 22;5(9):3329-36. doi: 10.3390/nu5093329. PMID: 23974065Free PMC Article

Therapy

Sun D, Ma R, Wang J, Wang Y, Ye Q
Front Immunol 2024;15:1325127. Epub 2024 Apr 22 doi: 10.3389/fimmu.2024.1325127. PMID: 38711527Free PMC Article
Wen J, Zhang J, Zhang H, Zhang N, Lei R, Deng Y, Cheng Q, Li H, Luo P
J Transl Med 2024 Apr 29;22(1):392. doi: 10.1186/s12967-024-04928-y. PMID: 38685026Free PMC Article
Liu L, Khan A, Sanchez-Rodriguez E, Zanoni F, Li Y, Steers N, Balderes O, Zhang J, Krithivasan P, LeDesma RA, Fischman C, Hebbring SJ, Harley JB, Moncrieffe H, Kottyan LC, Namjou-Khales B, Walunas TL, Knevel R, Raychaudhuri S, Karlson EW, Denny JC, Stanaway IB, Crosslin D, Rauen T, Floege J, Eitner F, Moldoveanu Z, Reily C, Knoppova B, Hall S, Sheff JT, Julian BA, Wyatt RJ, Suzuki H, Xie J, Chen N, Zhou X, Zhang H, Hammarström L, Viktorin A, Magnusson PKE, Shang N, Hripcsak G, Weng C, Rundek T, Elkind MSV, Oelsner EC, Barr RG, Ionita-Laza I, Novak J, Gharavi AG, Kiryluk K
Nat Commun 2022 Nov 11;13(1):6859. doi: 10.1038/s41467-022-34456-6. PMID: 36369178Free PMC Article
Makharia GK, Chauhan A, Singh P, Ahuja V
Aliment Pharmacol Ther 2022 Jul;56 Suppl 1:S3-S17. doi: 10.1111/apt.16787. PMID: 35815830
Veeraraghavan G, Leffler DA, Kaswala DH, Mukherjee R
Expert Rev Gastroenterol Hepatol 2015 Jul;9(7):913-27. Epub 2015 Apr 12 doi: 10.1586/17474124.2015.1033399. PMID: 25864708

Prognosis

Schirru E, Rossino R, Diana D, Jores RD, Baldera D, Muntoni S, Spiga C, Ripoli C, Ricciardi MR, Cucca F, Congia M
Clin Transl Gastroenterol 2024 Jul 1;15(7):e00710. doi: 10.14309/ctg.0000000000000710. PMID: 38713138Free PMC Article
Sun D, Ma R, Wang J, Wang Y, Ye Q
Front Immunol 2024;15:1325127. Epub 2024 Apr 22 doi: 10.3389/fimmu.2024.1325127. PMID: 38711527Free PMC Article
Soderquist CR, Lewis SK, Gru AA, Vlad G, Williams ES, Hsiao S, Mansukhani MM, Park DC, Bacchi CE, Alobeid B, Green PH, Bhagat G
Am J Surg Pathol 2021 Jul 1;45(7):905-916. doi: 10.1097/PAS.0000000000001658. PMID: 33544565
Hemminki K, Li X, Sundquist K, Sundquist J
Arthritis Rheum 2009 Sep;60(9):2845-7. doi: 10.1002/art.24749. PMID: 19714648
Lorini R, Gastaldi R, Traggiai C, Perucchin PP
Pediatr Endocrinol Rev 2003 Dec;1 Suppl 2:205-11; discussion 211. PMID: 16444160

Clinical prediction guides

Sun D, Ma R, Wang J, Wang Y, Ye Q
Front Immunol 2024;15:1325127. Epub 2024 Apr 22 doi: 10.3389/fimmu.2024.1325127. PMID: 38711527Free PMC Article
Liu L, Khan A, Sanchez-Rodriguez E, Zanoni F, Li Y, Steers N, Balderes O, Zhang J, Krithivasan P, LeDesma RA, Fischman C, Hebbring SJ, Harley JB, Moncrieffe H, Kottyan LC, Namjou-Khales B, Walunas TL, Knevel R, Raychaudhuri S, Karlson EW, Denny JC, Stanaway IB, Crosslin D, Rauen T, Floege J, Eitner F, Moldoveanu Z, Reily C, Knoppova B, Hall S, Sheff JT, Julian BA, Wyatt RJ, Suzuki H, Xie J, Chen N, Zhou X, Zhang H, Hammarström L, Viktorin A, Magnusson PKE, Shang N, Hripcsak G, Weng C, Rundek T, Elkind MSV, Oelsner EC, Barr RG, Ionita-Laza I, Novak J, Gharavi AG, Kiryluk K
Nat Commun 2022 Nov 11;13(1):6859. doi: 10.1038/s41467-022-34456-6. PMID: 36369178Free PMC Article
Emiralioglu N, Ademhan Tural D, Hizarcioglu Gulsen H, Ergen YM, Ozsezen B, Sunman B, Saltık Temizel İ, Yalcin E, Dogru D, Ozcelik U, Kiper N
Eur J Pediatr 2021 Sep;180(9):2807-2813. Epub 2021 Mar 25 doi: 10.1007/s00431-021-04011-4. PMID: 33765186
Renga G, Bellet MM, Stincardini C, Pariano M, Oikonomou V, Villella VR, Brancorsini S, Clerici C, Romani L, Costantini C
Front Immunol 2019;10:2844. Epub 2019 Dec 5 doi: 10.3389/fimmu.2019.02844. PMID: 31867008Free PMC Article
Lorini R, Gastaldi R, Traggiai C, Perucchin PP
Pediatr Endocrinol Rev 2003 Dec;1 Suppl 2:205-11; discussion 211. PMID: 16444160

Recent systematic reviews

Yang G, Zhang B, Huang W, Zhang N, Dong F, Jing L, Wang M, Liu Y, Guo C, Pan H, Wei X, Jing C
Expert Rev Gastroenterol Hepatol 2015;9(10):1327-38. Epub 2015 Aug 8 doi: 10.1586/17474124.2015.1075880. PMID: 26289103
Haines ML, Anderson RP, Gibson PR
Aliment Pharmacol Ther 2008 Nov 1;28(9):1042-66. Epub 2008 Jul 30 doi: 10.1111/j.1365-2036.2008.03820.x. PMID: 18671779

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