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Breast myoepithelial tumor

MedGen UID:
267411
•Concept ID:
C1511319
•
Neoplastic Process
Synonyms: Breast Myoepithelial Neoplasm; breast myoepithelial neoplasm; Breast Myoepithelial Tumor; breast myoepithelial tumor
 
Monarch Initiative: MONDO:0002483

Definition

A benign or malignant tumor that arises from the breast and originates from or is composed of myoepithelial cells. Representative examples include adenomyoepithelioma, myoepitheliosis, and malignant myoepithelioma. [from NCI]

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology.
Dewar R, Fadare O, Gilmore H, Gown AM
Arch Pathol Lab Med 2011 Apr;135(4):422-9. doi: 10.5858/2010-0336-CP.1. PMID: 21466356

Recent clinical studies

Etiology

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.
Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M
Cell 2022 Jan 20;185(2):299-310.e18. doi: 10.1016/j.cell.2021.12.023. PMID: 35063072Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258
Molecular markers for the diagnosis and management of ductal carcinoma in situ.
Polyak K
J Natl Cancer Inst Monogr 2010;2010(41):210-3. doi: 10.1093/jncimonographs/lgq019. PMID: 20956832Free PMC Article
Mammary epithelial stem cells.
Smith GH, Chepko G
Microsc Res Tech 2001 Jan 15;52(2):190-203. doi: 10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O. PMID: 11169867

Diagnosis

Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Preinvasive breast cancer.
Sgroi DC
Annu Rev Pathol 2010;5:193-221. doi: 10.1146/annurev.pathol.4.110807.092306. PMID: 19824828Free PMC Article
Current practical applications of diagnostic immunohistochemistry in breast pathology.
Lerwill MF
Am J Surg Pathol 2004 Aug;28(8):1076-91. doi: 10.1097/01.pas.0000126780.10029.f0. PMID: 15252316

Therapy

Dramatic Response to Carboplatin, Paclitaxel, and Radiation in a Patient With Malignant Myoepithelioma of the Breast.
Tran PN, Zhuang L, Nangia CI, Mehta RS
Oncologist 2016 Dec;21(12):1492-1494. Epub 2016 Jul 29 doi: 10.1634/theoncologist.2016-0092. PMID: 27473043Free PMC Article
Basal breast cancer: a complex and deadly molecular subtype.
Bertucci F, Finetti P, Birnbaum D
Curr Mol Med 2012 Jan;12(1):96-110. doi: 10.2174/156652412798376134. PMID: 22082486Free PMC Article
Molecular markers for the diagnosis and management of ductal carcinoma in situ.
Polyak K
J Natl Cancer Inst Monogr 2010;2010(41):210-3. doi: 10.1093/jncimonographs/lgq019. PMID: 20956832Free PMC Article
Triple negative breast carcinomas: similarities and differences with basal like carcinomas.
Lerma E, Barnadas A, Prat J
Appl Immunohistochem Mol Morphol 2009 Dec;17(6):483-94. doi: 10.1097/PAI.0b013e3181a725eb. PMID: 19620842
Timing of dietary estrogenic exposures and breast cancer risk.
De Assis S, Hilakivi-Clarke L
Ann N Y Acad Sci 2006 Nov;1089:14-35. doi: 10.1196/annals.1386.039. PMID: 17261753

Prognosis

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.
Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Molecular markers for the diagnosis and management of ductal carcinoma in situ.
Polyak K
J Natl Cancer Inst Monogr 2010;2010(41):210-3. doi: 10.1093/jncimonographs/lgq019. PMID: 20956832Free PMC Article
Adenomyoepithelioma of the breast. A report of three cases and review of the literature.
Young RH, Clement PB
Am J Clin Pathol 1988 Mar;89(3):308-14. doi: 10.1093/ajcp/89.3.308. PMID: 2831705
Histologic classification and further characterization of tumors in domestic animals.
Misdorp W
Adv Vet Sci Comp Med 1976;20:191-221. PMID: 188327

Clinical prediction guides

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment.
Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788Free PMC Article
Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.
Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Implications of nestin in breast cancer pathogenesis (Review).
Nowak A, Dziegiel P
Int J Oncol 2018 Aug;53(2):477-487. Epub 2018 Jun 14 doi: 10.3892/ijo.2018.4441. PMID: 29901100
Preinvasive breast cancer.
Sgroi DC
Annu Rev Pathol 2010;5:193-221. doi: 10.1146/annurev.pathol.4.110807.092306. PMID: 19824828Free PMC Article

Recent systematic reviews

Malignant breast myoepithelioma: A systematic review.
Huin M, Body G, Arbion F, Ouldamer L
J Gynecol Obstet Hum Reprod 2022 Dec;51(10):102481. Epub 2022 Oct 5 doi: 10.1016/j.jogoh.2022.102481. PMID: 36208828
Impact of adjuvant therapy on survival in patients with myoepithelial carcinoma: A systematic review and individual patient data analysis of 691 patients.
Giridhar P, Gupta P, Mallick S, Upadhyay AD, Rath GK
Radiother Oncol 2019 Nov;140:125-130. Epub 2019 Jul 2 doi: 10.1016/j.radonc.2019.06.017. PMID: 31276988

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