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Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

MedGen UID:
235367
•Concept ID:
C1334955
•
Neoplastic Process
Synonym: Neuroblastomas of Adrenal Gland and Sympathetic Nervous System

Definition

A common pediatric extracranial tumor arising from neural crest cells. It involves the adrenal medulla and the sympathetic nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroblastoma of the Adrenal Gland and Sympathetic Nervous System

Professional guidelines

PubMed

Eflornithine for treatment of high-risk neuroblastoma.
Jiang J, Yu Y
Trends Pharmacol Sci 2024 Jun;45(6):577-578. Epub 2024 May 14 doi: 10.1016/j.tips.2024.04.005. PMID: 38749882Free PMC Article
MIBG in neuroblastoma diagnosis and treatment.
Olecki E, Grant CN
Semin Pediatr Surg 2019 Dec;28(6):150859. Epub 2019 Nov 20 doi: 10.1016/j.sempedsurg.2019.150859. PMID: 31931960
Diagnosis and management of neuroblastoma in children.
Gilbert M
J Fla Med Assoc 1971 Nov;58(11):45-6. PMID: 5117656

Recent clinical studies

Etiology

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma.
Sainero-Alcolado L, Mushtaq M, Liaño-Pons J, Rodriguez-Garcia A, Yuan Y, Liu T, Ruiz-Pérez MV, Schlisio S, Bedoya-Reina O, Arsenian-Henriksson M
J Exp Clin Cancer Res 2022 Jul 19;41(1):226. doi: 10.1186/s13046-022-02399-x. PMID: 35850708Free PMC Article
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.
Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F
Nat Genet 2021 May;53(5):683-693. Epub 2021 Mar 25 doi: 10.1038/s41588-021-00806-1. PMID: 33767450
MIBG in neuroblastoma diagnosis and treatment.
Olecki E, Grant CN
Semin Pediatr Surg 2019 Dec;28(6):150859. Epub 2019 Nov 20 doi: 10.1016/j.sempedsurg.2019.150859. PMID: 31931960
Differences in Genomic Profiles and Outcomes Between Thoracic and Adrenal Neuroblastoma.
Oldridge DA, Truong B, Russ D, DuBois SG, Vaksman Z, Mosse YP, Diskin SJ, Maris JM, Matthay KK
J Natl Cancer Inst 2019 Nov 1;111(11):1192-1201. doi: 10.1093/jnci/djz027. PMID: 30793172Free PMC Article
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723

Diagnosis

Benign Neurogenic Tumors.
Farma JM, Porpiglia AS, Vo ET
Surg Clin North Am 2022 Aug;102(4):679-693. doi: 10.1016/j.suc.2022.04.007. PMID: 35952696
MIBG in neuroblastoma diagnosis and treatment.
Olecki E, Grant CN
Semin Pediatr Surg 2019 Dec;28(6):150859. Epub 2019 Nov 20 doi: 10.1016/j.sempedsurg.2019.150859. PMID: 31931960
Neuroblastoma (Peripheral neuroblastic tumours).
Luksch R, Castellani MR, Collini P, De Bernardi B, Conte M, Gambini C, Gandola L, Garaventa A, Biasoni D, Podda M, Sementa AR, Gatta G, Tonini GP
Crit Rev Oncol Hematol 2016 Nov;107:163-181. Epub 2016 Oct 6 doi: 10.1016/j.critrevonc.2016.10.001. PMID: 27823645
Rare tumours of the sympathetic nervous system.
Sidhu BS, Gupta AK, Bhardwaj DN, Singh A
J Indian Med Assoc 1979 Jul 1;73(1):11-5. PMID: 536595
Diagnosis and management of neuroblastoma in children.
Gilbert M
J Fla Med Assoc 1971 Nov;58(11):45-6. PMID: 5117656

Therapy

MIBG in neuroblastoma diagnosis and treatment.
Olecki E, Grant CN
Semin Pediatr Surg 2019 Dec;28(6):150859. Epub 2019 Nov 20 doi: 10.1016/j.sempedsurg.2019.150859. PMID: 31931960
Vascular skeletalization: a new concept to improve the resection rate in childhood neuroblastoma.
Liu Z, Xiao Y, Chen D, Wang Z
J Neurosurg Sci 2014 Jun;58(2):113-6. PMID: 24819488
Neuroblastoma: a disease requiring a multitude of imaging studies.
Kushner BH
J Nucl Med 2004 Jul;45(7):1172-88. PMID: 15235064
Pretreatment with [131I] metaiodobenzylguanidine and surgical resection of advanced neuroblastoma.
van Hasselt EJ, Heij HA, de Kraker J, Vos A, Voûte PA
Eur J Pediatr Surg 1996 Jun;6(3):155-8. doi: 10.1055/s-2008-1066495. PMID: 8817208
The current status of meta-iodobenzylguanidine and related agents for the diagnosis of neuro-endocrine tumors.
Shapiro B, Sisson JC, Shulkin BL, Gross MD, Zempel S
Q J Nucl Med 1995 Dec;39(4 Suppl 1):3-8. PMID: 9002740

Prognosis

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.
Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F
Nat Genet 2021 May;53(5):683-693. Epub 2021 Mar 25 doi: 10.1038/s41588-021-00806-1. PMID: 33767450
WNT signaling, the development of the sympathoadrenal-paraganglionic system and neuroblastoma.
Becker J, Wilting J
Cell Mol Life Sci 2018 Mar;75(6):1057-1070. Epub 2017 Oct 22 doi: 10.1007/s00018-017-2685-8. PMID: 29058015Free PMC Article
Neuroblastoma (Peripheral neuroblastic tumours).
Luksch R, Castellani MR, Collini P, De Bernardi B, Conte M, Gambini C, Gandola L, Garaventa A, Biasoni D, Podda M, Sementa AR, Gatta G, Tonini GP
Crit Rev Oncol Hematol 2016 Nov;107:163-181. Epub 2016 Oct 6 doi: 10.1016/j.critrevonc.2016.10.001. PMID: 27823645
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723
Tumors of the sympathetic nervous system in children. An appraisal of treatment and results.
Perez CA, Vietti T, Ackerman LV, Eagleton MD, Powers WE
Radiology 1967 Apr;88(4):750-60. doi: 10.1148/88.4.750. PMID: 6020941

Clinical prediction guides

Augmented efficacy of nano-formulated docetaxel plus curcumin in orthotopic models of neuroblastoma.
Di Francesco M, Pastorino F, Ferreira M, Fragassi A, Di Francesco V, Palange AL, Celia C, Di Marzio L, Cilli M, Bensa V, Ponzoni M, Decuzzi P
Pharmacol Res 2023 Feb;188:106639. Epub 2022 Dec 28 doi: 10.1016/j.phrs.2022.106639. PMID: 36586642
Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension.
Mühlethaler-Mottet A, Uccella S, Marchiori D, La Rosa S, Daraspe J, Balmas Bourloud K, Beck Popovic M, Eugster PJ, Grouzmann E, Abid K
Front Endocrinol (Lausanne) 2022;13:1027856. Epub 2022 Dec 1 doi: 10.3389/fendo.2022.1027856. PMID: 36531507Free PMC Article
Differences in Genomic Profiles and Outcomes Between Thoracic and Adrenal Neuroblastoma.
Oldridge DA, Truong B, Russ D, DuBois SG, Vaksman Z, Mosse YP, Diskin SJ, Maris JM, Matthay KK
J Natl Cancer Inst 2019 Nov 1;111(11):1192-1201. doi: 10.1093/jnci/djz027. PMID: 30793172Free PMC Article
Neuroblastoma: a disease requiring a multitude of imaging studies.
Kushner BH
J Nucl Med 2004 Jul;45(7):1172-88. PMID: 15235064
FURTHER OBSERVATIONS ON THE DETERMINATION OF CATECHOLAMINE METABOLITES IN TUMOURS OF SYMPATHETIC NERVOUS SYSTEM.
KAESER H, BETTEX M, VON STUDNITZ
Arch Dis Child 1964 Apr;39(204):168-71. doi: 10.1136/adc.39.204.168. PMID: 14131959Free PMC Article

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