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Anaplastic Kidney Wilms Tumor

MedGen UID:
231375
•Concept ID:
C1332289
•
Neoplastic Process
Synonyms: Anaplastic Renal Wilm's Tumor; Anaplastic Renal Wilms Tumor; Anaplastic Renal Wilms' Tumor

Definition

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia. Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia. When anaplasia is diffuse, it is associated with an unfavorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Kidney Wilms Tumor

Professional guidelines

PubMed

Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Management of bilateral Wilms tumours.
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188

Recent clinical studies

Etiology

Anaplasia in Wilms tumor: A critical review.
Vujanić GM, Mifsud W
Pediatr Blood Cancer 2024 Jul;71(7):e31000. Epub 2024 Apr 11 doi: 10.1002/pbc.31000. PMID: 38605554
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Overexpressed oncogenic tumor-self antigens.
Bright RK, Bright JD, Byrne JA
Hum Vaccin Immunother 2014;10(11):3297-305. doi: 10.4161/hv.29475. PMID: 25483660Free PMC Article
Recent advances in the genetics of childhood renal cancers: a report of the 3rd International Conference on the molecular and clinical genetics of childhood renal tumors, together with the Mitchell Ross symposium on anaplastic and other high risk embryonal tumors of childhood, 8-10th April 1999, Wistar Institute, Philadelphia, PA.
Jones KP, Grundy PE, Coppes MJ
Med Pediatr Oncol 2000 Aug;35(2):126-30. doi: 10.1002/1096-911x(200008)35:2<126::aid-mpo8>3.0.co;2-4. PMID: 10918236

Diagnosis

Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Management of bilateral Wilms tumours.
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Visual Diagnosis: New Lung Nodules in a 3-year-old Girl with Wilms Tumor.
Weaver MS, Federico S
Pediatr Rev 2016 Feb;37(2):e5-6. doi: 10.1542/pir.2015-0047. PMID: 26834231

Therapy

Vincristine, Irinotecan, and Bevacizumab in Relapsed Wilms Tumor With Diffuse Anaplasia.
Schiavetti A, Varrasso G, Collini P, Clerico A
J Pediatr Hematol Oncol 2018 May;40(4):331-333. doi: 10.1097/MPH.0000000000000934. PMID: 28859044
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101
Visual Diagnosis: New Lung Nodules in a 3-year-old Girl with Wilms Tumor.
Weaver MS, Federico S
Pediatr Rev 2016 Feb;37(2):e5-6. doi: 10.1542/pir.2015-0047. PMID: 26834231
Current and emerging chemotherapy treatment strategies for Wilms tumor in North America.
Gratias EJ, Dome JS
Paediatr Drugs 2008;10(2):115-24. doi: 10.2165/00148581-200810020-00006. PMID: 18345721
Wilms tumour: prognostic factors, staging, therapy and late effects.
Kaste SC, Dome JS, Babyn PS, Graf NM, Grundy P, Godzinski J, Levitt GA, Jenkinson H
Pediatr Radiol 2008 Jan;38(1):2-17. Epub 2007 Nov 17 doi: 10.1007/s00247-007-0687-7. PMID: 18026723

Prognosis

Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors.
Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Selected Diagnostically Challenging Pediatric Soft Tissue Tumors.
Al-Ibraheemi A, Kozakewich H, Perez-Atayde AR
Surg Pathol Clin 2015 Sep;8(3):399-418. doi: 10.1016/j.path.2015.05.009. PMID: 26297063

Clinical prediction guides

Long-term outcomes and patterns of relapse in patients with bilateral Wilms tumor or bilaterally predisposed unilateral Wilms tumor, a report from the COG AREN0534 study.
Murphy AJ, Brzezinski J, Renfro LA, Tornwall B, Malek MM, Benedetti DJ, Cost NG, Smith EA, Aldrink J, Romao RLP, Dome JS, Davidoff AM, Treece AL, Parsons LN, Mullen EA, Shamberger RC, Paulino AC, Lo AC, Geller JI, Ehrlich PF
Int J Cancer 2024 Nov 15;155(10):1824-1831. Epub 2024 Jul 8 doi: 10.1002/ijc.35080. PMID: 38973574Free PMC Article
Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors.
Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534.
Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Development of anaplastic Wilms tumor and subsequent relapse in a child with diaphanospondylodysostosis.
Tasian SK, Kim GE, Miniati DN, DuBois SG
J Pediatr Hematol Oncol 2012 Oct;34(7):548-51. doi: 10.1097/MPH.0b013e3182465b58. PMID: 22469945Free PMC Article

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