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Unilateral retinoblastoma

MedGen UID:
208929
•Concept ID:
C0854915
•
Neoplastic Process
Synonyms: Unilateral Retinoblastoma; unilateral retinoblastoma
 
Monarch Initiative: MONDO:0003076

Definition

A retinoblastoma that only involves a single eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnilateral retinoblastoma

Professional guidelines

PubMed

Treatment Outcomes and Definition Inconsistencies in High-Risk Unilateral Retinoblastoma.
Arazi M, Baum A, Casavilca-Zambrano S, Alarcon-Leon S, Diaz-Coronado R, Ahmad A, Mushtaq A, Hussain M, Ushakova T, Yuri S, Vladimir P, Shields CL, Eagle RC Jr, Berry JL, Pike S, Brown B, Roy SR, Huque F, Fabian I, Frenkel S, Eiger-Moscovich M, Pe'er J, Hubbard GB 3rd, Olson TA, Grossniklaus H, Reddy MA, Sagoo MS, Staffieri SE, Elder JE, McKenzie JD, Tanabe M, Kaliki S, Fabian ID
Am J Ophthalmol 2024 Dec;268:399-408. Epub 2024 Sep 25 doi: 10.1016/j.ajo.2024.09.023. PMID: 39332513
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing.
Berry JL, Lewis L, Zolfaghari E, Green S, Le BHA, Lee TC, Murphree AL, Kim JW, Jubran R
Ophthalmic Genet 2018 Jun;39(3):407-409. Epub 2017 Dec 29 doi: 10.1080/13816810.2017.1420807. PMID: 29286867Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750

Recent clinical studies

Etiology

Toxicity to intravitreal melphalan in a patient with retinoblastoma.
Solaz-Ruiz MG, Pérez LA, Cauto-Picazo C, Barranco-González H, Pascual-Camps I, España-Gregori E
Rom J Ophthalmol 2023 Jul-Sep;67(3):305-308. doi: 10.22336/rjo.2023.49. PMID: 37876503Free PMC Article
Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.
Awounou D, Lacour B, Desandes E, Guissou S, Cassoux N, Doz F, Dufour C, Minard-Colin V, Schleiermacher G, Taque S, Verschuur A, Clavel J, Goujon S
Cancer Med 2023 Apr;12(7):8789-8803. Epub 2023 Feb 1 doi: 10.1002/cam4.5624. PMID: 36726302Free PMC Article
Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring.
Kumar SV, Lupo PJ, Pompeii LA, Danysh HE
Int J Environ Res Public Health 2018 Mar 13;15(3) doi: 10.3390/ijerph15030505. PMID: 29533992Free PMC Article
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing.
Berry JL, Lewis L, Zolfaghari E, Green S, Le BHA, Lee TC, Murphree AL, Kim JW, Jubran R
Ophthalmic Genet 2018 Jun;39(3):407-409. Epub 2017 Dec 29 doi: 10.1080/13816810.2017.1420807. PMID: 29286867Free PMC Article
Orbital retinoblastoma: case report.
Mabtum ED, Bonanomi MT, Lima PP, Almeida MT
Arq Bras Oftalmol 2013 Jul-Aug;76(4):247-9. doi: 10.1590/s0004-27492013000400013. PMID: 24061839

Diagnosis

Toxicity to intravitreal melphalan in a patient with retinoblastoma.
Solaz-Ruiz MG, Pérez LA, Cauto-Picazo C, Barranco-González H, Pascual-Camps I, España-Gregori E
Rom J Ophthalmol 2023 Jul-Sep;67(3):305-308. doi: 10.22336/rjo.2023.49. PMID: 37876503Free PMC Article
Unilateral Retinoblastoma Metastatic to the Skull and Both Orbits.
Abramson DH, Haque S, Francis JH
Ophthalmol Retina 2020 Oct;4(10):1021. doi: 10.1016/j.oret.2020.04.019. PMID: 33019985
Simultaneous diagnosis of unilateral retinoblastoma and contralateral optic pathway glioma in a child with neurofibromatosis type 1.
Das A, Ghosh P, Zameer L, Ramprasad VL, Bhaduri A
Pediatr Hematol Oncol 2019 Mar;36(2):82-85. Epub 2019 Apr 9 doi: 10.1080/08880018.2019.1591550. PMID: 30963792
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing.
Berry JL, Lewis L, Zolfaghari E, Green S, Le BHA, Lee TC, Murphree AL, Kim JW, Jubran R
Ophthalmic Genet 2018 Jun;39(3):407-409. Epub 2017 Dec 29 doi: 10.1080/13816810.2017.1420807. PMID: 29286867Free PMC Article
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Therapy

Three vs 6 Cycles of Chemotherapy for High-Risk Retinoblastoma: A Randomized Clinical Trial.
Ye H, Xue K, Zhang P, Chen R, Zhai X, Ling L, Xiao W, Tang L, Wang H, Mao Y, Ai S, Bi Y, Liu Q, Zou Y, Qian J, Yang H
JAMA 2024 Nov 19;332(19):1634-1641. doi: 10.1001/jama.2024.19981. PMID: 39432296Free PMC Article
Toxicity to intravitreal melphalan in a patient with retinoblastoma.
Solaz-Ruiz MG, Pérez LA, Cauto-Picazo C, Barranco-González H, Pascual-Camps I, España-Gregori E
Rom J Ophthalmol 2023 Jul-Sep;67(3):305-308. doi: 10.22336/rjo.2023.49. PMID: 37876503Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring.
Kumar SV, Lupo PJ, Pompeii LA, Danysh HE
Int J Environ Res Public Health 2018 Mar 13;15(3) doi: 10.3390/ijerph15030505. PMID: 29533992Free PMC Article
Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.
Materin MA, Kuzmik GA, Jubinsky PT, Minja FJ, Asnes JD, Bulsara KR
J Neurointerv Surg 2013 Nov;5(6):e42. Epub 2012 Nov 27 doi: 10.1136/neurintsurg-2012-010508.rep. PMID: 23188789

Prognosis

Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.
Awounou D, Lacour B, Desandes E, Guissou S, Cassoux N, Doz F, Dufour C, Minard-Colin V, Schleiermacher G, Taque S, Verschuur A, Clavel J, Goujon S
Cancer Med 2023 Apr;12(7):8789-8803. Epub 2023 Feb 1 doi: 10.1002/cam4.5624. PMID: 36726302Free PMC Article
Unilateral retinoblastoma in a patient with Hermansky-Pudlak syndrome.
Burges M, King B, McGee R, Brennan R, Wilson M
Ophthalmic Genet 2019 Feb;40(1):83-85. Epub 2019 Feb 4 doi: 10.1080/13816810.2019.1571618. PMID: 30712445
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing.
Berry JL, Lewis L, Zolfaghari E, Green S, Le BHA, Lee TC, Murphree AL, Kim JW, Jubran R
Ophthalmic Genet 2018 Jun;39(3):407-409. Epub 2017 Dec 29 doi: 10.1080/13816810.2017.1420807. PMID: 29286867Free PMC Article
Orbital retinoblastoma: case report.
Mabtum ED, Bonanomi MT, Lima PP, Almeida MT
Arq Bras Oftalmol 2013 Jul-Aug;76(4):247-9. doi: 10.1590/s0004-27492013000400013. PMID: 24061839
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Clinical prediction guides

Three vs 6 Cycles of Chemotherapy for High-Risk Retinoblastoma: A Randomized Clinical Trial.
Ye H, Xue K, Zhang P, Chen R, Zhai X, Ling L, Xiao W, Tang L, Wang H, Mao Y, Ai S, Bi Y, Liu Q, Zou Y, Qian J, Yang H
JAMA 2024 Nov 19;332(19):1634-1641. doi: 10.1001/jama.2024.19981. PMID: 39432296Free PMC Article
Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.
Awounou D, Lacour B, Desandes E, Guissou S, Cassoux N, Doz F, Dufour C, Minard-Colin V, Schleiermacher G, Taque S, Verschuur A, Clavel J, Goujon S
Cancer Med 2023 Apr;12(7):8789-8803. Epub 2023 Feb 1 doi: 10.1002/cam4.5624. PMID: 36726302Free PMC Article
RB1 germline mutation spectrum and clinical features in patients with unilateral retinoblastomas.
Fang X, Chen J, Wang Y, Zhao M, Zhang X, Yang L, Ni X, Zhao J, Gallie BL
Ophthalmic Genet 2021 Oct;42(5):593-599. Epub 2021 Jun 30 doi: 10.1080/13816810.2021.1946703. PMID: 34190019
Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring.
Kumar SV, Lupo PJ, Pompeii LA, Danysh HE
Int J Environ Res Public Health 2018 Mar 13;15(3) doi: 10.3390/ijerph15030505. PMID: 29533992Free PMC Article
Maternal diet during pregnancy and unilateral retinoblastoma.
Lombardi C, Ganguly A, Bunin GR, Azary S, Alfonso V, Ritz B, Heck JE
Cancer Causes Control 2015 Mar;26(3):387-97. Epub 2014 Dec 27 doi: 10.1007/s10552-014-0514-z. PMID: 25542139Free PMC Article

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