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Disorder of iron metabolism and transport

MedGen UID:
1826109
•Concept ID:
C5681031
•
Disease or Syndrome
Synonym: disorder of iron metabolism and transport
 
Monarch Initiative: MONDO:0017763
Orphanet: ORPHA309842

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of iron metabolism and transport

Professional guidelines

PubMed

Pathophysiology and management of iron deficiency anaemia in pregnancy: a review.
Kirthan JPA, Somannavar MS
Ann Hematol 2024 Aug;103(8):2637-2646. Epub 2023 Oct 3 doi: 10.1007/s00277-023-05481-2. PMID: 37787837
The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials.
Granero R, Pardo-Garrido A, Carpio-Toro IL, Ramírez-Coronel AA, Martínez-Suárez PC, Reivan-Ortiz GG
Nutrients 2021 Nov 13;13(11) doi: 10.3390/nu13114059. PMID: 34836314Free PMC Article
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.
Zhang X, Zhang D, Jia H, Feng Q, Wang D, Liang D, Wu X, Li J, Tang L, Li Y, Lan Z, Chen B, Li Y, Zhong H, Xie H, Jie Z, Chen W, Tang S, Xu X, Wang X, Cai X, Liu S, Xia Y, Li J, Qiao X, Al-Aama JY, Chen H, Wang L, Wu QJ, Zhang F, Zheng W, Li Y, Zhang M, Luo G, Xue W, Xiao L, Li J, Chen W, Xu X, Yin Y, Yang H, Wang J, Kristiansen K, Liu L, Li T, Huang Q, Li Y, Wang J
Nat Med 2015 Aug;21(8):895-905. Epub 2015 Jul 27 doi: 10.1038/nm.3914. PMID: 26214836

Recent clinical studies

Etiology

Iron Deficiency Anemia: An Updated Review.
Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis.
He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M
J Hepatol 2023 Aug;79(2):362-377. Epub 2023 Mar 28 doi: 10.1016/j.jhep.2023.03.016. PMID: 36996941Free PMC Article
A role of PIEZO1 in iron metabolism in mice and humans.
Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, Loud M, Andolfo I, Patapoutian A
Cell 2021 Feb 18;184(4):969-982.e13. Epub 2021 Feb 10 doi: 10.1016/j.cell.2021.01.024. PMID: 33571427Free PMC Article
Congenital dyserythropoietic anemias.
Iolascon A, Andolfo I, Russo R
Blood 2020 Sep 10;136(11):1274-1283. doi: 10.1182/blood.2019000948. PMID: 32702750
Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article

Diagnosis

Iron Deficiency Anemia: An Updated Review.
Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Iron considerations for the athlete: a narrative review.
Sim M, Garvican-Lewis LA, Cox GR, Govus A, McKay AKA, Stellingwerff T, Peeling P
Eur J Appl Physiol 2019 Jul;119(7):1463-1478. Epub 2019 May 4 doi: 10.1007/s00421-019-04157-y. PMID: 31055680
Copper deficiency anemia: review article.
Myint ZW, Oo TH, Thein KZ, Tun AM, Saeed H
Ann Hematol 2018 Sep;97(9):1527-1534. Epub 2018 Jun 29 doi: 10.1007/s00277-018-3407-5. PMID: 29959467
Haemochromatosis.
Brissot P, Pietrangelo A, Adams PC, de Graaff B, McLaren CE, Loréal O
Nat Rev Dis Primers 2018 Apr 5;4:18016. doi: 10.1038/nrdp.2018.16. PMID: 29620054Free PMC Article

Therapy

Iron Deficiency Anemia: An Updated Review.
Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence.
Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010228. PMID: 31963141Free PMC Article
Copper deficiency anemia: review article.
Myint ZW, Oo TH, Thein KZ, Tun AM, Saeed H
Ann Hematol 2018 Sep;97(9):1527-1534. Epub 2018 Jun 29 doi: 10.1007/s00277-018-3407-5. PMID: 29959467
Disorders of iron metabolism.
Andrews NC
N Engl J Med 1999 Dec 23;341(26):1986-95. doi: 10.1056/NEJM199912233412607. PMID: 10607817

Prognosis

Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects.
Ferrao K, Ali N, Mehta KJ
J Mol Med (Berl) 2022 Dec;100(12):1673-1689. Epub 2022 Oct 10 doi: 10.1007/s00109-022-02254-8. PMID: 36214835Free PMC Article
The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy.
Deneubourg C, Ramm M, Smith LJ, Baron O, Singh K, Byrne SC, Duchen MR, Gautel M, Eskelinen EL, Fanto M, Jungbluth H
Autophagy 2022 Mar;18(3):496-517. Epub 2021 Aug 19 doi: 10.1080/15548627.2021.1943177. PMID: 34130600Free PMC Article
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.
Zhang X, Zhang D, Jia H, Feng Q, Wang D, Liang D, Wu X, Li J, Tang L, Li Y, Lan Z, Chen B, Li Y, Zhong H, Xie H, Jie Z, Chen W, Tang S, Xu X, Wang X, Cai X, Liu S, Xia Y, Li J, Qiao X, Al-Aama JY, Chen H, Wang L, Wu QJ, Zhang F, Zheng W, Li Y, Zhang M, Luo G, Xue W, Xiao L, Li J, Chen W, Xu X, Yin Y, Yang H, Wang J, Kristiansen K, Liu L, Li T, Huang Q, Li Y, Wang J
Nat Med 2015 Aug;21(8):895-905. Epub 2015 Jul 27 doi: 10.1038/nm.3914. PMID: 26214836
Gastric secretion.
Schubert ML
Curr Opin Gastroenterol 2014 Nov;30(6):578-82. doi: 10.1097/MOG.0000000000000125. PMID: 25211241
Cutting edge issues in autoimmune gastritis.
Toh BH, Chan J, Kyaw T, Alderuccio F
Clin Rev Allergy Immunol 2012 Jun;42(3):269-78. doi: 10.1007/s12016-010-8218-y. PMID: 21174235

Clinical prediction guides

Iron Deficiency Anemia: An Updated Review.
Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss.
Yang J, Li Q, Feng Y, Zeng Y
Int J Mol Sci 2023 Apr 7;24(8) doi: 10.3390/ijms24086891. PMID: 37108056Free PMC Article
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.
Zhang X, Xu Y, Ma L, Yu K, Niu Y, Xu X, Shi Y, Guo S, Xue X, Wang Y, Qiu S, Cui J, Wang H, Tian X, Miao Y, Meng F, Qiao Y, Yu Y, Wang J
Cancer Commun (Lond) 2022 Apr;42(4):287-313. Epub 2022 Feb 20 doi: 10.1002/cac2.12275. PMID: 35184419Free PMC Article
Wilson's disease: update on pathogenesis, biomarkers and treatments.
Shribman S, Poujois A, Bandmann O, Czlonkowska A, Warner TT
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1053-1061. Epub 2021 Aug 2 doi: 10.1136/jnnp-2021-326123. PMID: 34341141
Iron metabolism: pathophysiology and pharmacology.
Roemhild K, von Maltzahn F, Weiskirchen R, Knüchel R, von Stillfried S, Lammers T
Trends Pharmacol Sci 2021 Aug;42(8):640-656. Epub 2021 Jun 2 doi: 10.1016/j.tips.2021.05.001. PMID: 34090703Free PMC Article

Recent systematic reviews

Iron and ferritin deficiency in women with hypothyroidism and chronic lymphocytic thyroiditis - systematic review.
Gierach M, Rudewicz M, Junik R
Endokrynol Pol 2024;75(3):253-261. Epub 2024 Jun 26 doi: 10.5603/ep.97860. PMID: 38923898
Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis.
Li CP, Song YX, Lin ZJ, Ma ML, He LP
Curr Med Chem 2024;31(23):3604-3623. doi: 10.2174/0929867330666230428161653. PMID: 37132140Free PMC Article
The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials.
Granero R, Pardo-Garrido A, Carpio-Toro IL, Ramírez-Coronel AA, Martínez-Suárez PC, Reivan-Ortiz GG
Nutrients 2021 Nov 13;13(11) doi: 10.3390/nu13114059. PMID: 34836314Free PMC Article
Hepcidin: A Promising Therapeutic Target for Iron Disorders: A Systematic Review.
Liu J, Sun B, Yin H, Liu S
Medicine (Baltimore) 2016 Apr;95(14):e3150. doi: 10.1097/MD.0000000000003150. PMID: 27057839Free PMC Article
Ferroportin disease: a systematic meta-analysis of clinical and molecular findings.
Mayr R, Janecke AR, Schranz M, Griffiths WJ, Vogel W, Pietrangelo A, Zoller H
J Hepatol 2010 Nov;53(5):941-9. Epub 2010 Jul 17 doi: 10.1016/j.jhep.2010.05.016. PMID: 20691492Free PMC Article

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