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Invasive Male Breast Carcinoma

MedGen UID:
1788755
•Concept ID:
C5447280
•
Neoplastic Process

Definition

A rare invasive carcinoma that arises from the male breast. Morphologically, it is similar to the invasive carcinomas that arise from the female breast. It usually develops in the retroareolar region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Male Breast Carcinoma

Professional guidelines

PubMed

Therapeutic potential of [(177)Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment.
Yadav MP, Ballal S, Martin M, Roesch F, Satapathy S, Moon ES, Tripathi M, Gogia A, Bal C
Eur J Nucl Med Mol Imaging 2024 Feb;51(3):805-819. Epub 2023 Nov 7 doi: 10.1007/s00259-023-06482-z. PMID: 37932560
Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands.
de Blok CJM, Wiepjes CM, Nota NM, van Engelen K, Adank MA, Dreijerink KMA, Barbé E, Konings IRHM, den Heijer M
BMJ 2019 May 14;365:l1652. doi: 10.1136/bmj.l1652. PMID: 31088823Free PMC Article
Cathepsin K inhibitors as treatment of bone metastasis.
Le Gall C, Bonnelye E, Clézardin P
Curr Opin Support Palliat Care 2008 Sep;2(3):218-22. doi: 10.1097/SPC.0b013e32830baea9. PMID: 18685424

Recent clinical studies

Etiology

Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Breast invasive ductal carcinoma diagnosis with a three-miRNA panel in serum.
Chen X, Li X, Wang J, Zhao L, Peng X, Zhang C, Liu K, Huang G, Lai Y
Biomark Med 2021 Aug;15(12):951-963. Epub 2021 Jul 23 doi: 10.2217/bmm-2020-0785. PMID: 34293926
Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands.
de Blok CJM, Wiepjes CM, Nota NM, van Engelen K, Adank MA, Dreijerink KMA, Barbé E, Konings IRHM, den Heijer M
BMJ 2019 May 14;365:l1652. doi: 10.1136/bmj.l1652. PMID: 31088823Free PMC Article
Mammary fibromatosis.
Glazebrook KN, Reynolds CA
AJR Am J Roentgenol 2009 Sep;193(3):856-60. doi: 10.2214/AJR.08.1892. PMID: 19696302
Familial pancreatic cancer.
Rieder H, Bartsch DK
Fam Cancer 2004;3(1):69-74. doi: 10.1023/B:FAME.0000026822.67291.a1. PMID: 15131409

Diagnosis

Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Prognostic difficulties of men with breast cancer.
Fentiman IS
Breast J 2021 Dec;27(12):877-882. Epub 2021 Oct 15 doi: 10.1111/tbj.14297. PMID: 34652050
Male Breast Cancer.
Serdy KM, Leone JP, Dabbs DJ, Bhargava R
Am J Clin Pathol 2017 Jan 1;147(1):110-119. doi: 10.1093/ajcp/aqw207. PMID: 28171879
Mammary fibromatosis.
Glazebrook KN, Reynolds CA
AJR Am J Roentgenol 2009 Sep;193(3):856-60. doi: 10.2214/AJR.08.1892. PMID: 19696302
Male breast cancer.
Besznyák I, Eckhardt S
Ann Oncol 1994 Jan;5(1):83-5. doi: 10.1093/oxfordjournals.annonc.a058702. PMID: 8172798

Therapy

Ribociclib plus Endocrine Therapy in Early Breast Cancer.
Slamon D, Lipatov O, Nowecki Z, McAndrew N, Kukielka-Budny B, Stroyakovskiy D, Yardley DA, Huang CS, Fasching PA, Crown J, Bardia A, Chia S, Im SA, Ruiz-Borrego M, Loi S, Xu B, Hurvitz S, Barrios C, Untch M, Moroose R, Visco F, Afenjar K, Fresco R, Severin I, Ji Y, Ghaznawi F, Li Z, Zarate JP, Chakravartty A, Taran T, Hortobagyi G
N Engl J Med 2024 Mar 21;390(12):1080-1091. doi: 10.1056/NEJMoa2305488. PMID: 38507751
Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial.
Johnston SRD, Toi M, O'Shaughnessy J, Rastogi P, Campone M, Neven P, Huang CS, Huober J, Jaliffe GG, Cicin I, Tolaney SM, Goetz MP, Rugo HS, Senkus E, Testa L, Del Mastro L, Shimizu C, Wei R, Shahir A, Munoz M, San Antonio B, André V, Harbeck N, Martin M; monarchE Committee Members
Lancet Oncol 2023 Jan;24(1):77-90. Epub 2022 Dec 6 doi: 10.1016/S1470-2045(22)00694-5. PMID: 36493792Free PMC Article
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
Kerr J, Anderson C, Lippman SM
Lancet Oncol 2017 Aug;18(8):e457-e471. Epub 2017 Jul 26 doi: 10.1016/S1470-2045(17)30411-4. PMID: 28759385Free PMC Article
Chemoprevention of cancer.
Tsao AS, Kim ES, Hong WK
CA Cancer J Clin 2004 May-Jun;54(3):150-80. doi: 10.3322/canjclin.54.3.150. PMID: 15195789

Prognosis

Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands.
de Blok CJM, Wiepjes CM, Nota NM, van Engelen K, Adank MA, Dreijerink KMA, Barbé E, Konings IRHM, den Heijer M
BMJ 2019 May 14;365:l1652. doi: 10.1136/bmj.l1652. PMID: 31088823Free PMC Article
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
Kerr J, Anderson C, Lippman SM
Lancet Oncol 2017 Aug;18(8):e457-e471. Epub 2017 Jul 26 doi: 10.1016/S1470-2045(17)30411-4. PMID: 28759385Free PMC Article
Male Breast Cancer.
Serdy KM, Leone JP, Dabbs DJ, Bhargava R
Am J Clin Pathol 2017 Jan 1;147(1):110-119. doi: 10.1093/ajcp/aqw207. PMID: 28171879
Familial pancreatic cancer.
Rieder H, Bartsch DK
Fam Cancer 2004;3(1):69-74. doi: 10.1023/B:FAME.0000026822.67291.a1. PMID: 15131409

Clinical prediction guides

Male Invasive Lobular Breast Cancer: Clinicopathologic Features Including Recurrence Score Results From a Population-Based Database.
Balatico M, Ruano AL, Cleary AS, Lomo L, Gulbahce HE
Arch Pathol Lab Med 2024 Mar 1;148(3):263-264. doi: 10.5858/arpa.2023-0364-LE. PMID: 38408030
Breast invasive ductal carcinoma diagnosis with a three-miRNA panel in serum.
Chen X, Li X, Wang J, Zhao L, Peng X, Zhang C, Liu K, Huang G, Lai Y
Biomark Med 2021 Aug;15(12):951-963. Epub 2021 Jul 23 doi: 10.2217/bmm-2020-0785. PMID: 34293926
Genetic Factors, Adherence to Healthy Lifestyle Behavior, and Risk of Invasive Breast Cancer Among Women in the UK Biobank.
Arthur RS, Wang T, Xue X, Kamensky V, Rohan TE
J Natl Cancer Inst 2020 Sep 1;112(9):893-901. doi: 10.1093/jnci/djz241. PMID: 31899501Free PMC Article
(89)Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer.
Bensch F, van der Veen EL, Lub-de Hooge MN, Jorritsma-Smit A, Boellaard R, Kok IC, Oosting SF, Schröder CP, Hiltermann TJN, van der Wekken AJ, Groen HJM, Kwee TC, Elias SG, Gietema JA, Bohorquez SS, de Crespigny A, Williams SP, Mancao C, Brouwers AH, Fine BM, de Vries EGE
Nat Med 2018 Dec;24(12):1852-1858. Epub 2018 Nov 26 doi: 10.1038/s41591-018-0255-8. PMID: 30478423
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
Kerr J, Anderson C, Lippman SM
Lancet Oncol 2017 Aug;18(8):e457-e471. Epub 2017 Jul 26 doi: 10.1016/S1470-2045(17)30411-4. PMID: 28759385Free PMC Article

Recent systematic reviews

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Central pancreatectomy: a comprehensive, up-to-date meta-analysis.
Dragomir MP, Sabo AA, Petrescu GED, Li Y, Dumitrascu T
Langenbecks Arch Surg 2019 Dec;404(8):945-958. Epub 2019 Oct 22 doi: 10.1007/s00423-019-01829-3. PMID: 31641855
Breast cancer in transgender patients: A systematic review. Part 2: Female to Male.
Stone JP, Hartley RL, Temple-Oberle C
Eur J Surg Oncol 2018 Oct;44(10):1463-1468. Epub 2018 Jul 5 doi: 10.1016/j.ejso.2018.06.021. PMID: 30037639
Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.
Liang M, Zhang Y, Sun C, Rizeq FK, Min M, Shi T, Sun Y
Mol Diagn Ther 2018 Aug;22(4):397-407. doi: 10.1007/s40291-018-0344-x. PMID: 29909568
5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic review and meta-analysis.
Wang J, Zhao S, Luo L, Li E, Li X, Zhao Z
Int Braz J Urol 2018 Sep-Oct;44(5):865-873. doi: 10.1590/S1677-5538.IBJU.2017.0531. PMID: 29697934Free PMC Article

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