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Breast Neuroendocrine Tumor G2

MedGen UID:
1786564
•Concept ID:
C5446660
•
Neoplastic Process

Definition

A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the breast. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Neuroendocrine Tumor G2

Professional guidelines

PubMed

The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Alterations in Ki67 Labeling Following Treatment of Poorly Differentiated Neuroendocrine Carcinomas: A Potential Diagnostic Pitfall.
Vyas M, Tang LH, Rekhtman N, Klimstra DS
Am J Surg Pathol 2021 Jan;45(1):25-34. doi: 10.1097/PAS.0000000000001602. PMID: 33177340Free PMC Article
Radio hyperthermia for re-treatment of superficial tumours.
Gabriele P, Ferrara T, Baiotto B, Garibaldi E, Marini PG, Penduzzu G, Giovannini V, Bardati F, Guiot C
Int J Hyperthermia 2009 May;25(3):189-98. doi: 10.1080/02656730802669593. PMID: 19212860

Recent clinical studies

Etiology

Neuroendocrine Neoplasms of the Breast: Current Insights and Future Directions.
Jiang L, Pan X, Lang Z
Cancer Rep (Hoboken) 2024 Nov;7(11):e70059. doi: 10.1002/cnr2.70059. PMID: 39585672Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article

Diagnosis

Neuroendocrine Neoplasms of the Breast: Current Insights and Future Directions.
Jiang L, Pan X, Lang Z
Cancer Rep (Hoboken) 2024 Nov;7(11):e70059. doi: 10.1002/cnr2.70059. PMID: 39585672Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article

Therapy

TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING.
Bharti V, Kumar A, Wang Y, Roychowdhury N, de Lima Bellan D, Kassaye BB, Watkins R, Capece M, Chung CG, Hilinski G, Vilgelm AE
JCI Insight 2024 Jun 20;9(15) doi: 10.1172/jci.insight.177523. PMID: 38900577Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.
Deng S, Banerjee S, Chen H, Pochampally S, Wang Y, Yun MK, White SW, Parmar K, Meibohm B, Hartman KL, Wu Z, Miller DD, Li W
Cancer Lett 2023 Feb 28;555:216046. Epub 2022 Dec 31 doi: 10.1016/j.canlet.2022.216046. PMID: 36596380Free PMC Article
The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2.
Petrilli A, Copik A, Posadas M, Chang LS, Welling DB, Giovannini M, Fernández-Valle C
Oncogene 2014 Jul 3;33(27):3571-82. Epub 2013 Aug 12 doi: 10.1038/onc.2013.320. PMID: 23934191Free PMC Article

Prognosis

Neuroendocrine Neoplasms of the Breast: Current Insights and Future Directions.
Jiang L, Pan X, Lang Z
Cancer Rep (Hoboken) 2024 Nov;7(11):e70059. doi: 10.1002/cnr2.70059. PMID: 39585672Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome.
Bogina G, Munari E, Brunelli M, Bortesi L, Marconi M, Sommaggio M, Lunardi G, Gori S, Massocco A, Pegoraro MC, Zamboni G
Histopathology 2016 Feb;68(3):422-32. Epub 2015 Aug 17 doi: 10.1111/his.12766. PMID: 26114478

Clinical prediction guides

TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING.
Bharti V, Kumar A, Wang Y, Roychowdhury N, de Lima Bellan D, Kassaye BB, Watkins R, Capece M, Chung CG, Hilinski G, Vilgelm AE
JCI Insight 2024 Jun 20;9(15) doi: 10.1172/jci.insight.177523. PMID: 38900577Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells.
Cocciadiferro L, Miceli V, Granata OM, Carruba G
J Steroid Biochem Mol Biol 2017 Sep;172:222-230. Epub 2016 Jun 8 doi: 10.1016/j.jsbmb.2016.05.023. PMID: 27289045
Analysis of the cycling and noncycling cell population of human solid tumors.
Terz JJ, Lawrence W Jr, Cox B
Cancer 1977 Oct;40(4):1462-70. doi: 10.1002/1097-0142(197710)40:4<1462::aid-cncr2820400417>3.0.co;2-d. PMID: 907964

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