U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Breast Neoplasm

MedGen UID:
1737420
•Concept ID:
C5418756
•
Neoplastic Process

Definition

A malignant breast neoplasm that has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer.
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer.
Gennari A, André F, Barrios CH, Cortés J, de Azambuja E, DeMichele A, Dent R, Fenlon D, Gligorov J, Hurvitz SA, Im SA, Krug D, Kunz WG, Loi S, Penault-Llorca F, Ricke J, Robson M, Rugo HS, Saura C, Schmid P, Singer CF, Spanic T, Tolaney SM, Turner NC, Curigliano G, Loibl S, Paluch-Shimon S, Harbeck N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Dec;32(12):1475-1495. Epub 2021 Oct 19 doi: 10.1016/j.annonc.2021.09.019. PMID: 34678411
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937

Recent clinical studies

Etiology

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis.
Benitez Fuentes JD, Morgan E, de Luna Aguilar A, Mafra A, Shah R, Giusti F, Vignat J, Znaor A, Musetti C, Yip CH, Van Eycken L, Jedy-Agba E, Piñeros M, Soerjomataram I
JAMA Oncol 2024 Jan 1;10(1):71-78. doi: 10.1001/jamaoncol.2023.4837. PMID: 37943547Free PMC Article
Molecular and cellular mechanisms underlying brain metastasis of breast cancer.
Hosonaga M, Saya H, Arima Y
Cancer Metastasis Rev 2020 Sep;39(3):711-720. doi: 10.1007/s10555-020-09881-y. PMID: 32399646Free PMC Article
Bone Metastasis of Breast Cancer.
Tahara RK, Brewer TM, Theriault RL, Ueno NT
Adv Exp Med Biol 2019;1152:105-129. doi: 10.1007/978-3-030-20301-6_7. PMID: 31456182
Oligometastatic breast cancer.
Kwapisz D
Breast Cancer 2019 Mar;26(2):138-146. Epub 2018 Oct 15 doi: 10.1007/s12282-018-0921-1. PMID: 30324552
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Diagnosis

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis.
Benitez Fuentes JD, Morgan E, de Luna Aguilar A, Mafra A, Shah R, Giusti F, Vignat J, Znaor A, Musetti C, Yip CH, Van Eycken L, Jedy-Agba E, Piñeros M, Soerjomataram I
JAMA Oncol 2024 Jan 1;10(1):71-78. doi: 10.1001/jamaoncol.2023.4837. PMID: 37943547Free PMC Article
Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Treatment and care of patients with metastatic breast cancer.
Beaumont T, Leadbeater M
Nurs Stand 2011 Jun 8-14;25(40):49-56. doi: 10.7748/ns2011.06.25.40.49.c8566. PMID: 21755793
Introduction: role of surgery in the diagnosis and management of metastatic cancer.
Berger AC
Semin Oncol 2008 Apr;35(2):98-9. doi: 10.1053/j.seminoncol.2008.01.002. PMID: 18396194

Therapy

Oligometastatic breast cancer.
Kwapisz D
Breast Cancer 2019 Mar;26(2):138-146. Epub 2018 Oct 15 doi: 10.1007/s12282-018-0921-1. PMID: 30324552
Breast surgery for metastatic breast cancer.
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Palliation and breast cancer.
Yip CH
J Surg Oncol 2017 Apr;115(5):538-543. Epub 2017 Jan 18 doi: 10.1002/jso.24560. PMID: 28097656
Breast cancer.
Bailey HH, Carbone PP
Cancer Chemother Biol Response Modif 1993;14:557-76. PMID: 8312119
Metastatic breast cancer.
Rubens RD
Curr Opin Oncol 1993 Nov;5(6):991-5. doi: 10.1097/00001622-199311000-00007. PMID: 8305549

Prognosis

Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial.
Xu B, Yan M, Ma F, Hu X, Feng J, Ouyang Q, Tong Z, Li H, Zhang Q, Sun T, Wang X, Yin Y, Cheng Y, Li W, Gu Y, Chen Q, Liu J, Cheng J, Geng C, Qin S, Wang S, Lu J, Shen K, Liu Q, Wang X, Wang H, Luo T, Yang J, Wu Y, Yu Z, Zhu X, Chen C, Zou J; PHOEBE Investigators
Lancet Oncol 2021 Mar;22(3):351-360. Epub 2021 Feb 11 doi: 10.1016/S1470-2045(20)30702-6. PMID: 33581774
Esthesioneuroblastoma metastatic to the breast.
Moalla S, Gharbi S, Mbarki C, Chennoufi H, Melliti S, Mezghani Boussetta S
Breast J 2018 Sep;24(5):836-837. Epub 2018 May 20 doi: 10.1111/tbj.13054. PMID: 29781189
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394
Pulmonary resection for metastatic breast cancer.
Staren ED, Salerno C, Rongione A, Witt TR, Faber LP
Arch Surg 1992 Nov;127(11):1282-4. doi: 10.1001/archsurg.1992.01420110024006. PMID: 1444787
The Neuro-Oncology Register.
Lassouw GM, Twijnstra A, Schouten LJ, van de Pol M
Neuroepidemiology 1992;11(4-6):261-6. doi: 10.1159/000110939. PMID: 1291890

Clinical prediction guides

Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study.
Lång K, Josefsson V, Larsson AM, Larsson S, Högberg C, Sartor H, Hofvind S, Andersson I, Rosso A
Lancet Oncol 2023 Aug;24(8):936-944. doi: 10.1016/S1470-2045(23)00298-X. PMID: 37541274
Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
Biganzoli L, Battisti NML, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, de Glas NA, Trimboli RM, Korc-Grodzicki B, Soto-Perez-de-Celis E, Ponti A, Tsang J, Marotti L, Benn K, Aapro MS, Brain EGC
Lancet Oncol 2021 Jul;22(7):e327-e340. Epub 2021 May 14 doi: 10.1016/S1470-2045(20)30741-5. PMID: 34000244
Imaging Tumor Proliferation in Breast Cancer: Current Update on Predictive Imaging Biomarkers.
Elmi A, McDonald ES, Mankoff D
PET Clin 2018 Jul;13(3):445-457. doi: 10.1016/j.cpet.2018.02.007. PMID: 30100082Free PMC Article
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Diagnosis of recurrent and metastatic disease using f-18 fluorodeoxyglucose-positron emission tomography in breast cancer.
Eubank WB
Radiol Clin North Am 2007 Jul;45(4):659-67, vi. doi: 10.1016/j.rcl.2007.05.005. PMID: 17706530

Recent systematic reviews

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis.
Benitez Fuentes JD, Morgan E, de Luna Aguilar A, Mafra A, Shah R, Giusti F, Vignat J, Znaor A, Musetti C, Yip CH, Van Eycken L, Jedy-Agba E, Piñeros M, Soerjomataram I
JAMA Oncol 2024 Jan 1;10(1):71-78. doi: 10.1001/jamaoncol.2023.4837. PMID: 37943547Free PMC Article
Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy: A systematic review and meta-analysis.
Becherini C, Visani L, Caini S, Bhattacharya IS, Kirby AM, Nader Marta G, Morgan G, Salvestrini V, Coles CE, Cortes J, Curigliano G, de Azambuja E, Harbeck N, Isacke CM, Kaidar-Person O, Marangoni E, Offersen B, Rugo HS, Morandi A, Lambertini M, Poortmans P, Livi L, Meattini I
Cancer Treat Rev 2023 Sep;119:102586. Epub 2023 Jun 15 doi: 10.1016/j.ctrv.2023.102586. PMID: 37336117
Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.
Henry NL, Somerfield MR, Dayao Z, Elias A, Kalinsky K, McShane LM, Moy B, Park BH, Shanahan KM, Sharma P, Shatsky R, Stringer-Reasor E, Telli M, Turner NC, DeMichele A
J Clin Oncol 2022 Sep 20;40(27):3205-3221. Epub 2022 Jun 27 doi: 10.1200/JCO.22.01063. PMID: 35759724
Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update.
Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
Breast surgery for metastatic breast cancer.
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...